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General Information
Symbol
Dmel\tefuΔ356
Species
D. melanogaster
Name
FlyBase ID
FBal0124385
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Comment:

    Imprecise excision of the EP(3)0859 P-element, deleting 8773 nucleotides, including the first 8 coding exons of tefu. Position of mutation on reference sequence inferred by FlyBase curator.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Deletion breakpoint within tefu. The deletion removes the first 8 exons of tefu.

    Caused by aberration
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    tefu1/tefuΔ356 mutant wing discs exhibit a partial arrest phenotype at low doses of irradiation.

    tefuΔ356 animals (created by combining Df(3R)Hsc70-4Δ356 and Hsc70-4+t14 to rescue defects cause by the disruption of the Hsc70-4+t14 gene in that Deficiency) die shortly before eclosion. They exhibit a rough eye phenotype, misshapen wings and missing or abnormal bristles. Similar effects are see when combined with Df(3R)PG4 also. tefu1/tefured31 animals exhibit rough eyes, notched wings, and shorter or missing bristles, but do survive to adulthood. Mutant wing discs exhibit extremely high levels of spontaneous apoptosis, particularly in the basal region of the disc.

    Most tefuΔ356 homozygous flies (Df(3R)Hsc70-4Δ356 homozygotes in which the lack of Hsc70-4 function has been rescued by Hsc70-4+t14) show pupal lethality, although 15% eclose and are viable. These adult escapers do not survive for very long after eclosion. Escaper females do not lay eggs. Adult escapers have a notched wing phenotype. Third larval instar tefuΔ356 wing and eye discs (from Df(3R)Hsc70-4Δ356 animals in which the lack of Hsc70-4 function has been rescued by Hsc70-4+t14) show a substantial increase in the number of apoptotic cells compared to wild-type discs. Mitotic neuroblasts from tefuΔ356 brains (from Df(3R)Hsc70-4Δ356 animals in which the lack of Hsc70-4 function has been rescued by Hsc70-4+t14) often show evidence of chromosomal damage; in particular, telomere fusions are seen in 65.5% of metaphase figures. Both single and double telomere associations are seen, including fusions between sister chromatids as well as between homologous and nonhomologous chromosomes.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressed by
    NOT suppressed by
    Statement
    Reference

    tefuΔ356 has lethal | recessive | pupal stage phenotype, non-suppressible by p5311-1B-1

    Phenotype Manifest In
    Suppressed by
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Expression of p53R155H.Scer\UAS.Ex under the control of Scer\GAL4en-e16E results in a substantial decrease in apoptosis (in the domain of Scer\GAL4en-e16E expression) in third larval instar tefuΔ356 wing discs (from Df(3R)Hsc70-4Δ356 animals in which the lack of Hsc70-4 function has been rescued by Hsc70-4+t14).

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Fails to complement
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (4)