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General Information
Symbol
Dmel\SerBd-3
Species
D. melanogaster
Name
FlyBase ID
FBal0015418
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
BdG
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Partial duplication of the Ser locus in close proximity to the normal Ser location and insertion of roo into the coding region. roo insertion causes premature truncation of the transcript deleting the extracellular Cys-rich region and transmembrane and intracellular domains.

Molecular polymorphisms at 0 to 1.0 and 14 to 17 kb.

Insertion components
roo{}SerBd-3
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygous mutants have significantly fewer circulating crystal cells.

The combination of the SerBd-3 and Ser+r83k alleles in trans results in the development of a vestigial wing.

Strong synergistic effects are seen in flies expressing HScer\UAS.cGa under the control of Scer\GAL4T113 and also carrying SerBd-3.

Heterozygotes exhibit loss of anterior wing margin material with associated bristles and hairs. SerBd-3/SerD transheterozygotes exhibit loss of distal wing margin material, similar to SerD heterozygotes. Heterozygotes with Serrev6-1 or Df(3R)Bd appear phenotypically identical to SerBd-3 heterozygotes Heterozygotes with Df(3R)Dl-BX6 are lethal (due in part to a second site lethal on the Ser chromosome), a 'cleaned up' e SerBd-3 chromosome when heterozygous with Df(3R)Dl-BX6 has reduced viability and survivors exhibit rough eyes, duplicated bristles and greatly reduced wing blades. Further replacement of proximal chromosomal regions (recombining P{lacZ-un3}Y488 insertion onto Ser chromosome) allows full viability when heterozygous with Df(3R)Dl-BX6, but still with severe wing phenotypes. Heterozygotes with SerBd-3, Df(3R)Dl-M2, Df(3R)Dl-BX12 and DlB2 are viable and exhibit a severe wing phenotype. SerBd-3/Ser+r83k transheterozygotes are pupal lethal.

Homozygotes die at the late embryo/early larval stage and exhibit defects in head structures, particularly in the development of the mouth hooks.

Heterozygotes with Ser+r83k die as pharate adults with abnormalities in the leg such as fusion of the femur and tibial segments and loss of the wing blade.

Flies exposed to the restrictive temperature between 48-96 hours AEL display a ripped wing phenotype. Overall shape of the wing is also affected, narrower spacing between the longitudinal veins.

SerBd-3 Ser+r83k combination is lethal, flies die as pupae and when dissected from the pupal case they exhibit eye roughening, lack of wing blade and haltere material and fusion of the first and second tarsal segment of all six legs.

Like SerBd-1 but more extreme; not overlapping wild type in stock. Balancers also reduced with no overlap. Partially suppressed by H. Schultz and Curry report recurrent small or welt-like eye effect that is not well understood but is in chromosome 3 and may be an effect of SerBd-3. SerBd-3/SerBd-1 lethal. Dominant wing phenotype.

Wing nicking phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

SerBd-3 has visible | adult stage phenotype, enhanceable by Kap-α3D93

SerBd-3 has visible | adult stage phenotype, enhanceable by Kap-α3D165

Suppressed by
Statement
Reference

SerBd-3/Ser+r83k has visible phenotype, suppressible | partially by N414

SerBd-3/Ser+r83k has visible phenotype, suppressible | partially by Nl93

SerBd-3/Ser+r83k has visible phenotype, suppressible | partially by Nl1N-B

Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

SerBd-3 is a non-enhancer of visible phenotype of upd1GMR.PB

NOT Suppressor of
Statement
Reference

SerBd-3 is a non-suppressor of visible phenotype of upd1GMR.PB

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

SerBd-3 has wing blade phenotype, enhanceable by Kap-α3S033513

SerBd-3 has wing margin phenotype, enhanceable by Kap-α3S033513

SerBd-3 has wing blade phenotype, enhanceable by Kap-α3D93

SerBd-3 has wing margin phenotype, enhanceable by Kap-α3D93

SerBd-3 has wing blade phenotype, enhanceable by Kap-α3D165

SerBd-3 has wing margin phenotype, enhanceable by Kap-α3D165

SerBd-3 has phenotype, enhanceable by M285M285

Suppressed by
Statement
Reference

SerBd-3/Ser+r83k has wing phenotype, suppressible | partially by N414

SerBd-3/Ser+r83k has wing phenotype, suppressible | partially by Nl93

SerBd-3/Ser+r83k has wing phenotype, suppressible | partially by Nl1N-B

NOT Enhancer of
Statement
Reference

SerBd-3 is a non-enhancer of eye phenotype of upd1GMR.PB

NOT Suppressor of
Statement
Reference

SerBd-3 is a non-suppressor of eye phenotype of upd1GMR.PB

Additional Comments
Genetic Interactions
Statement
Reference

The large nicks in the anterior wing margin observed in SerBd-3 heterozygous adult flies are exacerbated by combination with single copy of any of the following alleles: Kap-α3D93, Kap-α3D165 or Kap-α3S033513 leading to a substantial loss of wing material in the anterior part of the blade.

The addition of Df(1)N-81k1 or NAx-59d has no effect on the SerBd-3/Ser+r83k wing phenotype. The addition of Nl1N-B, N414 or Nl93 partially suppresses the phenotype.

Heterozygous SerBd-3 flies exhibit a wing nicking phenotype. Heterozygous SerBd-3 enhances the wing nicking phenotype seen in mamN.Scer\UAS, Scer\GAL4C96.

Flies heterozygous for SerBd-3 and Dp(3;3)bxd110 have wing blades that are indistinguishable from those with normal Dl doses.

SerBd-3/Ser+ wgl-12/wg+ flies raised at 17oC have wings reduced to a stump.

In combination with Nl93 or Df(1)N-54l9, SerBd-3/Ser+r83k escapers exhibit phenotypically normal eyes and legs but lack halteres and had wing blades one half normal size.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer

Goldschmidt, 1934.

R.B. Goldschmidt.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (11)
References (26)