DlScer\UAS.cLa, SerScer\UAS.cGa double-mutant third instar nota clones (under the regulation of Scer\GAL4mat.αTub67C.T:Hsim\VP16) typically contain ten or more ectopic sensory organ precursors. Addition of the SerScer\UAS.cGa transgene, to DlRevF10 SerRX106 double mutant third instar nota clones, under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16, partially rescues the ectopic SOP phenotype, with approximately 26% of SOP positions exhibiting between one and four SOPs.
The transformation of the trichogen to a tormogen fate in the notal macrochaetae caused by SerScer\UAS.cGa expressed under the control of Scer\GAL4l(3)31-1-31-1 is enhanced by Df(3R)Dl-M2 and suppressed by Tp(3;3)bxd110. The bristle transformation phenotype seen when both SerScer\UAS.cGa and DlScer\UAS.cJa are expressed under the control of Scer\GAL4l(3)31-1-31-1 appears to be additive. The transformation of the trichogen to a tormogen fate in the notal macrochaetae caused by SerScer\UAS.cGa expressed under the control of Scer\GAL4l(3)31-1-31-1 is suppressed by co-expression of fngScer\UAS.cKa.
Expression in a fng- background causes dorsal cell proliferation (displacing the dorsal/ventral margin). Scer\GAL4hs.PB-mediated expression causes death prior to the end of embryogenesis. Mutants display severely reduced neuronal differentiation. Simultaneous expression with fngScer\UAS.cKa reduces lethality associated with ectopic expression of Ser and restores normal neuronal differentiation, flies develop into phenotypically wild type adults.
SerScer\UAS.cGa rescues wing development in SerBd-3/Ser+r83k flies in the presence of Scer\GAL4Ser.5.PY, Scer\GAL4Ser.6.PY or Scer\GAL4Ser.7.PY, partially rescues in the presence of Scer\GAL4Ser.3.PY, and fails to rescue in the presence of Scer\GAL4Ser.1.PY, Scer\GAL4Ser.2.PY or, Scer\GAL4Ser.3.PY.