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Gu, Y., Hukriede, N.A., Fleming, R.J. (1995). Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo.  Development 121(3): 855--865.
FlyBase ID
FBrf0076147
Publication Type
Research paper
Abstract

Serrate and Delta encode structurally related proteins in D. melanogaster that bind within a common extracellular region on the NOTCH receptor molecule. We used ectopic expression to determine if SERRATE could mediate in vivo functions parallel or antagonistic to those proposed for the putative NOTCH ligand DELTA. Our results demonstrate that Serrate can replace Delta gene function during embryonic neuroblast segregation and that expression of Serrate leads to a NOTCH-dependent suppression of achaete expression in proneural clusters. Our findings strongly suggest that SERRATE functions as an alternative ligand capable of NOTCH activation.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference
    Aberrations (3)
    Alleles (10)
    Balancers (1)
    Genes (7)
    Molecular Constructs (3)
    Insertions (1)
    Experimental Tools (2)
    Transgenic Constructs (4)