FlyBase Allele Report: Dmel\Kap-α3[D165]

General Information

Symbol

Dmel\Kap-α3^D165

Species

D. melanogaster

Name

FlyBase ID

FBal0160266

Feature type

allele

Associated gene

Dmel\Kap-α3

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Mason et al., 2003)

Mutagen

Delta2-3 transposase

(Mason et al., 2003)

Progenitor genotype

Kap-α3^S033513

(Mason et al., 2003)

Cytology

Description

Imprecise excision of P{lacW}Kap-α3^S033513 has deleted 615bp from the 5' region of Kap-α3. The Kap-α3 ORF is unaffected.

(Mason et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Mason et al., 2003)

fertile | female (with Kap-α3^D93)

(Mason et al., 2003)

lethal (with Kap-α3^D93)

(Mason et al., 2003)

lethal - all die before end of larval stage

(Mason et al., 2003)

lethal - all die before end of larval stage (with Df(3R)by416)

(Mason et al., 2003)

lethal - all die before end of larval stage (with Df(3R)GB104)

(Mason et al., 2003)

lethal - all die before end of larval stage (with Kap-α3^17-7)

(Mason et al., 2003)

lethal - all die before end of larval stage (with Kap-α3^w73)

(Mason et al., 2003)

some die during larval stage

(Mason et al., 2003)

some die during larval stage (with Df(3R)by416)

(Mason et al., 2003)

some die during larval stage (with Df(3R)GB104)

(Mason et al., 2003)

some die during larval stage (with Kap-α3^17-7)

(Mason et al., 2003)

some die during larval stage (with Kap-α3^w73)

(Mason et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Kap-α3^D165 is an enhancer of visible | adult stage phenotype of N¹

(Sachan et al., 2013)

Kap-α3^D165 is an enhancer of visible | adult stage phenotype of N^nd-3

(Sachan et al., 2013)

Kap-α3^D165 is an enhancer of visible | adult stage phenotype of Delta^5F

(Sachan et al., 2013)

Kap-α3^D165 is an enhancer of visible | adult stage phenotype of Ser^Bd-3

(Sachan et al., 2013)

Kap-α3^D165 is an enhancer of visible | adult stage | male phenotype of dx¹⁵²

(Sachan et al., 2013)

Suppressor of

Statement

Reference

Kap-α3^D165 is a suppressor of visible | adult stage phenotype of N^Ax-16

(Sachan et al., 2013)

Phenotype Manifest In

Enhancer of

Statement

Reference

Kap-α3^D165 is an enhancer of wing margin phenotype of N¹

(Sachan et al., 2013)

Kap-α3^D165 is an enhancer of wing vein | male phenotype of dx¹⁵²

(Sachan et al., 2013)

Kap-α3^D165 is an enhancer of wing margin phenotype of N^nd-3

(Sachan et al., 2013)

Kap-α3^D165 is an enhancer of wing vein phenotype of Delta^5F

(Sachan et al., 2013)

Kap-α3^D165 is an enhancer of wing blade phenotype of Ser^Bd-3

(Sachan et al., 2013)

Kap-α3^D165 is an enhancer of wing margin phenotype of Ser^Bd-3

(Sachan et al., 2013)

Suppressor of

Statement

Reference

Kap-α3^D165 is a suppressor of wing vein L5 phenotype of N^Ax-16

(Sachan et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The wing margin notching phenotype observed in some N¹ heterozygous females and in N^nd-3 hemizygous males, the wing vein deltas and thickening observed in Dl^5F heterozygotes as well as the large nicks in the anterior wing margin seen in Ser^Bd-3 heterozygous flies are each exacerbated by combination with a single copy of the Kap-α3^D165 allele.

The shortened longitudinal L5 phenotype characteristic for N^Ax-16 heterozygous females is suppressed by combination with a single copy of the Kap-α3^D165 allele.

The wing vein deltas and extra vein material observed in dx¹⁵² hemizygous adult males is exacerbated by combination with a single copy of the Kap-α3^D165 allele. No wing defects are observed in adult females double heterozygote for dx¹⁵² and Kap-α3^D165.

(Sachan et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Kap-α3^D93/Kap-α3^D165 is partially rescued by Scer\GAL4^αTub84B.PL/Kap-α3^-UTR.UASp

(Mason et al., 2003)

Comments

Kap-α3^{-UTR.Scer\UAS.P\T}; Scer\GAL4^αTub84B.PL weakly rescues the larval lethality of Kap-α3^D93/Kap-α3^D165 : around 40% still die as larvae, but about 50% die as pupae and about 10% as pharate adults.

(Mason et al., 2003)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Kap-α3^D165

imp α3^D165

(Sachan et al., 2013)

α3^D165

(Mason et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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