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General Information
Symbol
Dmel\N1
Species
D. melanogaster
Name
FlyBase ID
FBal0029933
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    N1/+ flies display wing margin defects in the distal region.

    N1 heterozygous adult females frequently display nicks in the wing margin.

    N1 homozygous lateral antennal lobe neuroblast clones, induced at the newly-hatched larval stage, produce double the number of uniglomerular lateral antennal lobe projection neurons at 24-48 hours after larval hatching and 4 times the number at 48-72 hours after larval hatching, with no acceleration of cell proliferation (EdU incorporation) compared to control clones.

    N1/+ wings have small notches at the wing margin.

    Mutant males (derived from heterozygous females) do not survive to adulthood. Heterozygous females are viable but have notched wings.

    N1/+ adult females show wing defects that include thickening of the longitudinal vein 5.

    Homozygous clones induced in the eye and thoracic imaginal discs show epidermal development indistinguishable from wild-type.

    Intermediate embryonic neurogenic phenotype.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference

    N1 has visible | dominant phenotype, enhanceable by Taf9190/e(y)1[+]

    N1 has visible | adult stage phenotype, enhanceable by Kap-α3D93

    N1 has visible | adult stage phenotype, enhanceable by Kap-α3D165

    N1 has visible | adult stage phenotype, enhanceable by Kap-α3S033513

    N1 has visible phenotype, enhanceable by Caf1-105[+]/Caf1-10536

    Suppressed by
    Statement
    Reference

    N1 has visible | dominant phenotype, suppressible by Traf6[+]/Traf6ex1

    N1 has lethal | male phenotype, suppressible | partially by dgrn[+]/dgrnEY09862

    NOT suppressed by
    Statement
    Reference

    N1 has visible | dominant | female phenotype, non-suppressible by N1/N[+]

    Enhancer of
    Statement
    Reference

    N1/N[+] is an enhancer of visible phenotype of Scer\GAL4A9, uifasterisk.UAS

    NOT Suppressor of
    Statement
    Reference

    N1/N[+] is a non-suppressor of visible | dominant | female phenotype of N1

    Other
    Phenotype Manifest In
    Enhanced by
    Statement
    Reference

    N1 has wing margin phenotype, enhanceable by N+/N264-39

    N1 has wing margin phenotype, enhanceable by Kap-α3D93

    N1 has wing margin phenotype, enhanceable by Kap-α3D165

    N1 has wing margin phenotype, enhanceable by Kap-α3S033513

    N1 has wing phenotype, enhanceable by Caf1-105[+]/Caf1-10536

    Suppressed by
    Statement
    Reference

    N1 has wing phenotype, suppressible by Traf6[+]/Traf6ex1

    NOT suppressed by
    Statement
    Reference

    N1 has wing | female phenotype, non-suppressible by N1/N[+]

    Enhancer of
    Statement
    Reference
    NOT Suppressor of
    Statement
    Reference

    N1/N[+] is a non-suppressor of wing | female phenotype of N1

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    One copy of Traf6ex1 rescues the wing notching phenotype seen in N1 mutant heterozygotes.

    The wing margin notching phenotype observed in some N1 heterozygous females is exacerbated by combination with single copy of any of the following alleles: Kap-α3D93, Kap-α3D165 or Kap-α3S033513.

    One copy of N1 enhances the small eye phenotype seen when Caf1-105NIG.12892R is expressed under the control of Scer\GAL4ey.PH.

    One copy of N1 enhances the wing phenotypes seen when Caf1-105NIG.12892R is expressed under the control of Scer\GAL4sd.PU. The entire wing margin fails to develop in these flies. Longitudinal veins 3 and 5 are much more thickened than those of N1/+ flies.

    One copy of Caf1-10536 enhances the penetrance of the notched wing phenotype seen in N1 mutant flies.

    The wing vein phenotype resulting from the expression of uifasterisk.Scer\UAS under the control of Scer\GAL4A9 is enhanced by N1/+.

    The male lethality caused by N1 is partially rescued by dgrnEY09862/+.

    dgrnDK/+ does not suppress the wing notching phenotype of N1/+ females.

    Xenogenetic Interactions
    Statement
    Reference

    N1/+ females ectopically expressing Hsap\ATXN1LScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4hh.PU rarely survive to adult stage (less than 10%) and the survivors display severe wing defects including a further thickening of the vein L5 compared to N1/+ controls.

    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    References (14)