FlyBase Allele Report: Dmel\mam[2]

General Information

Symbol

Dmel\mam²

Species

D. melanogaster

Name

FlyBase ID

FBal0012010

Feature type

allele

Associated gene

Dmel\mam

Associated Insertion(s)

Carried in Construct

Also Known As

mam^IB99

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates alveolar rhabdomyosarcoma

modeled by Hsap\FOXO1::Hsap\PAX7^UAS.cGa

(Galindo et al., 2014)

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | neurogenic phenotype | recessive

(Lehmann et al., 1983)

some die during embryonic stage | recessive

(Lehmann et al., 1983)

visible | somatic clone

(Nagel et al., 2000)

Phenotype Manifest In

cuticle & macrochaeta | somatic clone

(Dietrich and Campos-Ortega, 1984)

embryonic/larval cuticle

(Schmid et al., 1996)

embryonic epidermis | lateral

(Lehmann et al., 1983)

embryonic epidermis | ventral

(Lehmann et al., 1983)

eye | somatic clone

(Dietrich and Campos-Ortega, 1984)

eye photoreceptor cell | somatic clone

(Dietrich and Campos-Ortega, 1984)

interommatidial bristle | somatic clone

(Dietrich and Campos-Ortega, 1984)

macrochaeta | somatic clone

(Nagel et al., 2000, Dietrich and Campos-Ortega, 1984)

ommatidium | somatic clone

(Dietrich and Campos-Ortega, 1984)

pigment cell | somatic clone

(Dietrich and Campos-Ortega, 1984)

presumptive embryonic/larval central nervous system

(Schmid et al., 1996)

stomatogastric nervous system primordium

(Gonzalez-Gaitan and Jäckle, 1995)

thecogen cell | somatic clone

(Nagel et al., 2000)

tormogen cell | somatic clone

(Nagel et al., 2000)

trichogen cell | somatic clone

(Nagel et al., 2000)

Detailed Description

Statement

Reference

Lack of external bristle structures are seen in mam² somatic clones. they are correlated with a loss of internal cell types: typically, only solitary neurons are observed instead of neural hypertrophy or the wild-type thecogen/neuron pairs.

(Nagel et al., 2000)

Embryonic CNS exhibits moderate disturbances and larval exhibit moderate cuticle loss.

(Schmid et al., 1996)

Instead of forming distinct invagination folds, the mam mutant stomodeal nervous system anlage invaginates en masse.

(Gonzalez-Gaitan and Jäckle, 1995)

Defects in neuroblasts, sensillum precursors, sensory neurons, peripheral glial cells, oenocytes, optic lobe, somatogastric nervous system, salivary gland, Malpighian tubules, trachea, somatic musculature and cardioblasts. Foregut, endoderm and larval midgut are wild type.

(Hartenstein et al., 1992)

Homozygous clones in the eye have a severely disturbed ommatidial pattern, visible as a scar in the eye surface. Ommatidia are larger than wild-type and interommatidial bristles are missing. Each ommatidium contains more retinula cells and fewer pigment cells than wild-type. Each ommatidium contains more receptor cells than normal, and may contain up to 13 receptor cells. Homozygous clones in the cuticle lack all bristles.

(Dietrich and Campos-Ortega, 1984)

Intermediate embryonic neurogenic phenotype. A segmented plate of dorsal cuticle is connected by means of two epidermal bridges to the remains of the cephalic cuticle. Posterior spiracles are still evident.

(Lehmann et al., 1983)

stronger allele

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

mam²/mam[+] is an enhancer of visible | dominant phenotype of N¹

(Chang et al., 2021)

mam²/mam[+] is an enhancer of visible phenotype of Caf1-105^NIG.12892R, Scer\GAL4^ey.PH

(Yu et al., 2013)

mam²/mam[+] is an enhancer of visible phenotype of arm^S44Y.GMR

(Kankel et al., 2007)

mam²/mam[+] is an enhancer of visible phenotype of arm^S56F.GMR

(Kankel et al., 2007)

Suppressor of

Statement

Reference

mam²/mam[+] is a suppressor of partially lethal - majority die phenotype of Hsap\FOXO1::Hsap\PAX7^UAS.cGa, Scer\GAL4^Mhc.PW

(Galindo et al., 2014)

mam²/mam[+] is a suppressor | partially of visible | heat sensitive phenotype of Dcr-2^UAS.cDa, Eogt^GD5084, Scer\GAL4^en.PU

(Müller et al., 2013)

Phenotype Manifest In

Enhancer of

Statement

Reference

mam²/mam[+] is an enhancer of wing margin phenotype of N¹

(Chang et al., 2021)

mam²/mam[+] is an enhancer of eye phenotype of Caf1-105^NIG.12892R, Scer\GAL4^ey.PH

(Yu et al., 2013)

mam²/mam[+] is an enhancer of eye phenotype of arm^S44Y.GMR

(Kankel et al., 2007)

mam²/mam[+] is an enhancer of eye phenotype of arm^S56F.GMR

(Kankel et al., 2007)

Suppressor of

Statement

Reference

mam²/mam[+] is a suppressor | partially of wing blade posterior compartment | heat sensitive phenotype of Dcr-2^UAS.cDa, Eogt^GD5084, Scer\GAL4^en.PU

(Müller et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The wing blistering phenotype seen in the posterior compartment of wings in flies expressing Eogt^GD5084 under the control of Scer\GAL4^en.PU in the presence of Dcr-2^Scer\UAS.cDa is dominantly partially suppressed if the flies are also heterozygous for mam².

(Müller et al., 2013)

One copy of mam² enhances the small eye phenotype seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^ey.PH.

(Yu et al., 2013)

mam²/+ enhances the arm^S44Y.GMR and arm^S56F.GMR eye phenotypes.

(Kankel et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

3983

cn¹ mam² bw¹ speck¹/CyO

Kyoto

107541

cn¹ mam² bw¹ speck¹/CyO

Notes on Origin

Discoverer

Comments

Complements: Lac^k11012b.

(Beitel and Krasnow, 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

mam²

(Chang et al., 2021, Galindo et al., 2014, Müller et al., 2013, Yu et al., 2013, Endo et al., 2007, Kankel et al., 2007)

mam^IB99

(Rusconi and Corbin, 1998, Leviten and Posakony, 1996, Schmid et al., 1996, Gonzalez-Gaitan and Jäckle, 1995, Johnson et al., 1995, Kooh et al., 1993, Hartenstein et al., 1992, Dietrich and Campos-Ortega, 1984, Lehmann et al., 1983)

mam^IB

(Jacobs et al., 1989, Tearle and Nusslein-Volhard, 1987)

Name Synonyms

Secondary FlyBase IDs

References (22)

Report Sections

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