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General Information
Symbol
Dmel\mam2
Species
D. melanogaster
Name
FlyBase ID
FBal0012010
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
mamIB99
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Lack of external bristle structures are seen in mam2 somatic clones. they are correlated with a loss of internal cell types: typically, only solitary neurons are observed instead of neural hypertrophy or the wild-type thecogen/neuron pairs.

Embryonic CNS exhibits moderate disturbances and larval exhibit moderate cuticle loss.

Instead of forming distinct invagination folds, the mam mutant stomodeal nervous system anlage invaginates en masse.

Defects in neuroblasts, sensillum precursors, sensory neurons, peripheral glial cells, oenocytes, optic lobe, somatogastric nervous system, salivary gland, Malpighian tubules, trachea, somatic musculature and cardioblasts. Foregut, endoderm and larval midgut are wild type.

Homozygous clones in the eye have a severely disturbed ommatidial pattern, visible as a scar in the eye surface. Ommatidia are larger than wild-type and interommatidial bristles are missing. Each ommatidium contains more retinula cells and fewer pigment cells than wild-type. Each ommatidium contains more receptor cells than normal, and may contain up to 13 receptor cells. Homozygous clones in the cuticle lack all bristles.

Intermediate embryonic neurogenic phenotype. A segmented plate of dorsal cuticle is connected by means of two epidermal bridges to the remains of the cephalic cuticle. Posterior spiracles are still evident.

stronger allele

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

mam2/mam[+] is an enhancer of visible phenotype of Caf1-105NIG.12892R, Scer\GAL4ey.PH

mam2/mam[+] is an enhancer of visible phenotype of armS44Y.GMR

mam2/mam[+] is an enhancer of visible phenotype of armS56F.GMR

Suppressor of
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

mam2/mam[+] is an enhancer of eye phenotype of Caf1-105NIG.12892R, Scer\GAL4ey.PH

mam2/mam[+] is an enhancer of eye phenotype of armS44Y.GMR

mam2/mam[+] is an enhancer of eye phenotype of armS56F.GMR

Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa is dominantly partially suppressed if the flies are also heterozygous for mam2.

One copy of mam2 enhances the small eye phenotype seen when Caf1-105NIG.12892R is expressed under the control of Scer\GAL4ey.PH.

mam2/+ enhances the armS44Y.GMR and armS56F.GMR eye phenotypes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (21)