FlyBase Allele Report: Dmel\Traf6[ex1]

General Information

Symbol

Dmel\Traf6^ex1

Species

D. melanogaster

Name

FlyBase ID

FBal0194141

Feature type

allele

Associated gene

Dmel\Traf6

Associated Insertion(s)

Carried in Construct

Also Known As

Traf2^Ex1

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Cha et al., 2003)

Mutagen

Delta2-3 transposase

(Cha et al., 2003)

Progenitor genotype

Traf6^EP1516

(Cha et al., 2003)

Cytology

Description

Imprecise excision of the P{EP} element, resulting in a 2.7kb deletion from within the Traf2 gene.

(Cha et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Moy et al., 2014, Cha et al., 2003)

viable

(Cha et al., 2003)

visible | recessive

(Mishra et al., 2014)

Phenotype Manifest In

wing

(Mishra et al., 2014)

Detailed Description

Statement

Reference

No wing notching is seen in Traf6^ex1/+ mutant flies. Traf6^ex1 homozygous adult wings show mild irregularities and forked tips at the distal end of veins.

(Mishra et al., 2014)

Compared with wild-type, homozygous Traf6^ex1 mutant flies show elevated viral RNA levels after infection with Rift Valley Fever Virus (RVFV).

(Moy et al., 2014)

Traf6^ex1 mutant flies are fully resistant to infection by gram-negative bacteria, and survival rates are comparable to wild-type.

(Leulier et al., 2006)

Traf2^ex1 adults show no morphological defects.

(Cha et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Traf6^ex1 is a suppressor of visible phenotype of Scer\GAL4^pnr.PU, ben^EP1651

(Ma et al., 2014)

Traf6^ex1 is a suppressor of visible phenotype of Scer\GAL4^ey.PU, ben^d09936

(Ma et al., 2014)

Traf6[+]/Traf6^ex1 is a suppressor | partially of visible phenotype of Scer\GAL4^bbg-C96, dx^UAS.Tag:FLAG, krz^UAS.Tag:HA

(Mishra et al., 2014)

Traf6[+]/Traf6^ex1 is a suppressor of visible | dominant phenotype of N¹

(Mishra et al., 2014)

Traf6[+]/Traf6^ex1 is a suppressor of increased cell death phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Traf6^ex1 is a suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Ma et al., 2012)

Traf6[+]/Traf6^ex1 is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Xue et al., 2007)

Traf6^ex1/Traf6^ex1 is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Xue et al., 2007)

NOT Suppressor of

Statement

Reference

Traf6^ex1/Traf6^ex1 is a non-suppressor of visible phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Xue et al., 2007)

Phenotype Manifest In

Suppressor of

Statement

Reference

Traf6^ex1 is a suppressor of scutellum phenotype of Scer\GAL4^ey.PU, ben^EP1651

(Ma et al., 2014)

Traf6^ex1 is a suppressor of eye phenotype of Scer\GAL4^ey.PU, ben^d09936

(Ma et al., 2014)

Traf6[+]/Traf6^ex1 is a suppressor | partially of wing phenotype of Scer\GAL4^bbg-C96, dx^UAS.Tag:FLAG, krz^UAS.Tag:HA

(Mishra et al., 2014)

Traf6[+]/Traf6^ex1 is a suppressor of wing phenotype of N¹

(Mishra et al., 2014)

Traf6[+]/Traf6^ex1 is a suppressor of eye phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Traf6^ex1 is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Ma et al., 2012)

Traf6[+]/Traf6^ex1 is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Xue et al., 2007)

Traf6^ex1/Traf6^ex1 is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Xue et al., 2007)

NOT Suppressor of

Statement

Reference

Traf6^ex1/Traf6^ex1 is a non-suppressor of eye phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Xue et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Traf6^ex1 suppresses the rough eye phenotype seen when ben^d09936 is expressed under the control of Scer\GAL4^ey.PU.

Traf6^ex1 suppresses the small scutellum phenotype seen when ben^EP1651 is expressed under the control of Scer\GAL4^pnr.PU.

(Ma et al., 2014)

One copy of Traf6^ex1 rescues the wing notching phenotype seen in N¹ mutant heterozygotes.

One copy of Traf6^ex1 rescues the wing notching phenotype seen in Df(1)N-54l9 mutant heterozygotes.

dx¹/Traf6^ex1 transheterozygotes exhibit a wing vein thickening phenotype.

One copy of Traf6^ex1 partially suppresses the wing nicking phenotype seen when krz^{Scer\UAS.T:Ivir\HA1} and dx^{Scer\UAS.T:Zzzz\FLAG} are expressed under the control of Scer\GAL4^bbg-C96. The resulting flies exhibit loss of L4 vein material.

(Mishra et al., 2014)

egr^Scer\UAS.cIa-induced cell death is partially suppressed in hemizygous Traf6^ex1 mutant males.

(Ma et al., 2012)

The small-eye phenotype caused by expression of egr^Scer\UAS.cIa under the control of Scer\GAL4^GMR.PF is strongly suppressed by Traf6^ex1/+ and is completely suppressed by Traf6^ex1/Traf6^ex1.

Homozygosity for Traf6^ex1 has no effect on the mutant eye phenotype caused by expression of Tak1^Scer\UAS.cMa under the control of Scer\GAL4^hs.2sev.

(Xue et al., 2007)

Xenogenetic Interactions

Statement

Reference

A Traf6^ex1/+ background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

(Yang et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

82149

w^* Traf6^ex1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

DTRAF2^ex1

(Ma et al., 2014)

DTRAF2^ex

(Xue et al., 2007)

DTRAF2ex1

(Cha et al., 2003)

TRAF2^Ex

(Yang et al., 2013)

TRAF2^ex1

(Mishra et al., 2014)

Traf2^Ex1

(Leulier et al., 2006)

Traf2^ex1

Traf6 EP1516-ex1

(Garcia et al., 2024)

Traf6^EPex1

(Garcia et al., 2024)

Traf6^ex1

(Trombley et al., 2023, Zhu et al., 2019, Mathew et al., 2011)

dTRAF2^ex1.1

(Ma et al., 2012)

dTraf6^Ex1

(Moy et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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