FlyBase Allele Report: Dmel\Traf6[EP1516]

General Information

Symbol

Dmel\Traf6^EP1516

Species

D. melanogaster

Name

FlyBase ID

FBal0190077

Feature type

allele

Associated gene

Dmel\Traf6

Associated Insertion(s)

P{EP}GIIIspla2^EP1516

Carried in Construct

Also Known As

EP(X)1516

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{EP}GIIIspla2^EP1516

Cytology

Description

A P{EP} element is inserted in the 5' flanking region of Traf2.

(Cha et al., 2003)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:8,157,624..8,157,624 [-]

(Cha et al., 2005, Lee et al., 2005, Cha et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Overexpression of Traf2^EP1516 under the regulation of Scer\GAL4^ap-md544 has no effect on thorax closure.

(Cha et al., 2005)

Expression of Traf2^EP1516 under the control of Scer\GAL4^GMR.PF does not affect eye development.

The eye imaginal discs from transgenic flies overexpressing Traf2^EP1516 under the control of Scer\GAL4^GMR.PF do not show increased apoptotic cell death compared to wild-type discs.

(Cha et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Traf6^EP1516/Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Traf6^EP1516/Scer\GAL4^GMR.PF is a non-enhancer of ommatidium phenotype of Scer\GAL4^GMR.PF, Traf4^EP578

(Cha et al., 2003)

Traf6^EP1516/Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, Traf4^EP578

(Cha et al., 2003)

Traf6^EP1516/Scer\GAL4^GMR.PF is a non-enhancer of eye photoreceptor cell phenotype of Scer\GAL4^GMR.PF, Traf4^EP578

(Cha et al., 2003)

Suppressor of

Statement

Reference

Traf6^EP1516/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

NOT Suppressor of

Statement

Reference

Traf6^EP1516/Scer\GAL4^GMR.PF is a non-suppressor of eye photoreceptor cell phenotype of Scer\GAL4^GMR.PF, Traf4^EP578

(Cha et al., 2003)

Traf6^EP1516/Scer\GAL4^GMR.PF is a non-suppressor of ommatidium phenotype of Scer\GAL4^GMR.PF, Traf4^EP578

(Cha et al., 2003)

Traf6^EP1516/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, Traf4^EP578

(Cha et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Traf2^EP1516, with park^{Scer\UAS.T:Hsap\MYC}, in the notum of the wing imaginal discs, under the regulation of Scer\GAL4^ap-md544 suppresses the park^{Scer\UAS.T:Hsap\MYC} phenotype of thoracic cleft formation resulting from abnormalities in JNK signalling during thorax closure.

Co-expression of CG1583^EP1516, with park^{Scer\UAS.T:Hsap\MYC}, in the notum of the wing imaginal discs, under the regulation of Scer\GAL4^ap-md544 suppresses the park^{Scer\UAS.T:Hsap\MYC} phenotype of thoracic cleft formation resulting from abnormalities in JNK signalling during thorax closure.

(Cha et al., 2005)

Coexpression of Traf2^EP1516 with Traf1^EP578, under the control of Scer\GAL4^GMR.PF, does not alter the rough-eye phenotype caused

by sole overexpression of Traf1^EP578.

Coexpression of Traf2^EP1516 with either bsk^Scer\UAS.cBa or hep^Scer\UAS.cBa, under the control of Scer\GAL4^GMR.PF, does not affect the development of eyes.

(Cha et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

17006

w¹¹¹⁸ P{EP}GIIIspla2^EP1516 Traf6^EP1516

Notes on Origin

Discoverer

Comments

Overexpression of Traf2^EP1516 under the control of Scer\GAL4^hs.PB following a heat shock leads to an increase in Traf2 transcript levels.

(Cha et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

EP(X)DTRAF2

(Kim et al., 2006)

Traf2^EP1516

(Cha et al., 2005)

Traf6^EP1516

(Ketosugbo et al., 2017)

UAS-Traf6^EP1516

(Ketosugbo et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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