FB2026_02 , released June 18, 2026
Allele: Dmel\Kap-α3-UTR.UASp
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General Information
Symbol
Dmel\Kap-α3-UTR.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0176093
Feature type
allele
Associated gene
Dmel\Kap-α3
Associated Insertion(s)
Carried in Construct
P{UASp-Kap-α3.-UTR}
Key Links
Transgenic product class
wild_type
(Mason et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Mason et al., 2003)
Mutagen
in vitro construct
(Mason et al., 2003)
Progenitor genotype
Carried in construct
P{UASp-Kap-α3.-UTR}
Cytology
Description

UASp regulatory sequences drive expression of the Kap-α3 ORF (no UTRs).

(Mason et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Kap-α3
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4VP16.nanos.UTR/Kap-α3-UTR.UASp is a non-suppressor of nurse cell ring canal phenotype of PenD14

      (Mason et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Kap-α3-UTR.Scer\UAS.P\T under the control of Scer\GAL4Act5C.PI does not restore fertility in Df(3L)α1S1 males.

      Expression of Kap-α3-UTR.Scer\UAS.P\T under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 does not restore fertility or fecundity in Df(3L)α1S1 females.

      (Ratan et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4αTub84B.PL/Kap-α3-UTR.UASp rescues Kap-α317-7/Kap-α3D93

      (Mason et al., 2003)

      Scer\GAL4αTub84B.PL/Kap-α3-UTR.UASp rescues Kap-α3w73/Kap-α3D93

      (Mason et al., 2003)
      Partially rescues

      Scer\GAL4αTub84B.PL/Kap-α3-UTR.UASp partially rescues Df(3R)GB104/Kap-α3D93

      (Mason et al., 2003)

      Scer\GAL4αTub84B.PL/Kap-α3-UTR.UASp partially rescues Kap-α3D93/Kap-α3D165

      (Mason et al., 2003)

      Scer\GAL4ey.PH/Kap-α3-UTR.UASp partially rescues Kap-α3D93

      (Mason et al., 2003)

      Scer\GAL4αTub84B.PL/Kap-α3-UTR.UASp partially rescues Kap-α3D93

      (Mason et al., 2003)
      Comments

      Kap-α3-UTR.Scer\UAS.P\T; Scer\GAL4αTub84B.PL weakly rescues the larval lethality of Kap-α3D93/Kap-α3D93, Kap-α3D93/Kap-α3D165 (around 40% still die as larvae, but about 50% die as pupae and about 10% as pharate adults) and Kap-α3D93/Df(3R)GB104 (about 30% survive to pupate before dying). Kap-α3-UTR.Scer\UAS.P\T; Scer\GAL4αTub84B.PL rescues Kap-α3D93/Kap-α317-7 and Kap-α3D93/Kap-α3w73 to fully viable, fertile adults. Kap-α3-UTR.Scer\UAS.P\T; Scer\GAL4ey.PH partially rescues the eye phenotypes due to Kap-α3D93 somatic clones: Externally, individual ommatidia are much more distinct than without rescue, but most interommatidial bristles are missing. Sectioning reveals ommatidia to be somewhat disorganised and misshapen, with incorrect numbers of photoreceptors per ommatidium. Unlike in the non-rescued animals, rhabdomeres are present.

      (Mason et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Kap-α3-UTR.Scer\UAS.P\T
      Kap-α3-UTR.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (3)