FlyBase Allele Report: Dmel\Fs(2)Ket[RE34]

General Information

Symbol

Dmel\Fs(2)Ket^RE34

Species

D. melanogaster

Name

FlyBase ID

FBal0089701

Feature type

allele

Associated gene

Dmel\Fs(2)Ket

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Erdelyi et al., 1997)

Progenitor genotype

Fs(2)Ket³

(Virágh et al., 2012, Erdelyi et al., 1997)

Cytology

Description

Amino acid replacement: D725N.

(Virágh et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:20,738,358..20,738,358 [+]

Nucleotide change:

G20738358A

Amino acid change:

Reported amino acid change:

D725N

Comment:

A revertant that carries a D725N mutation in addition to the original P446L mutation of Fs(2)Ket³. Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Virágh et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | dominant | cold sensitive

(Erdelyi et al., 1997)

lethal - all die before end of larval stage | recessive

(Erdelyi et al., 1997)

partially lethal - majority live | maternal effect

(Virágh et al., 2012)

some die during embryonic stage | maternal effect

(Virágh et al., 2012)

some die during larval stage | recessive

(Erdelyi et al., 1997)

Phenotype Manifest In

Detailed Description

Statement

Reference

Temperature sensitive period is during the last stages of oogenesis.

(Erdelyi et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Fs(2)Ket^RE34 has increased mortality during development | maternal effect phenotype, enhanceable by Pen^D14

(Virágh et al., 2012)

Fs(2)Ket^RE34 has increased mortality during development | maternal effect phenotype, enhanceable by Scer\GAL4^{VP16.nanos.UTR}/Kap-α3^GD14213

(Virágh et al., 2012)

Fs(2)Ket^RE34 has increased mortality during development | maternal effect phenotype, enhanceable by RanGAP^EP1173

(Virágh et al., 2012)

Fs(2)Ket^RE34 has increased mortality during development | maternal effect phenotype, enhanceable by RanGAP^EY21763

(Virágh et al., 2012)

Fs(2)Ket^RE34 has increased mortality during development | maternal effect phenotype, enhanceable by Scer\GAL4^{VP16.nanos.UTR}/Pen^GD10665

(Virágh et al., 2012)

Fs(2)Ket^RE34 has increased mortality during development | maternal effect phenotype, enhanceable by Df(3L)α1S1

(Virágh et al., 2012)

Fs(2)Ket^RE34 has increased mortality during development | maternal effect phenotype, enhanceable by Kap-α3^17-7

(Virágh et al., 2012)

Fs(2)Ket^RE34 has increased mortality during development | maternal effect phenotype, enhanceable by Scer\GAL4^{VP16.nanos.UTR}/Kap-α1^GD13960

(Virágh et al., 2012)

Suppressed by

Statement

Reference

Fs(2)Ket^RE34, Pen^D14 has increased mortality during development | maternal effect phenotype, suppressible | partially by Pen^+t6

(Virágh et al., 2012)

Fs(2)Ket^RE34, Pen^D14 has increased mortality during development | maternal effect phenotype, suppressible | partially by Scer\GAL4^{VP16.nanos.UTR}/Pen^UASp.cGa

(Virágh et al., 2012)

Fs(2)Ket^RE34, Pen^D14 has increased mortality during development | maternal effect phenotype, suppressible | partially by Scer\GAL4^{VP16.nanos.UTR}/Pen^-UTR.UASp

(Virágh et al., 2012)

Fs(2)Ket^RE34, Pen^D14 has increased mortality during development | maternal effect phenotype, suppressible | partially by Fs(2)Ket^+t13.8

(Virágh et al., 2012)

Fs(2)Ket^RE34 has increased mortality during development | maternal effect phenotype, suppressible by Df(3L)W5.4

(Virágh et al., 2012)

NOT suppressed by

Statement

Reference

Fs(2)Ket^RE34, Pen^D14 has increased mortality during development | maternal effect phenotype, non-suppressible by Scer\GAL4^{VP16.nanos.UTR}/Kap-α1^UASp.cMa

(Virágh et al., 2012)

Fs(2)Ket^RE34, Pen^D14 has increased mortality during development | maternal effect phenotype, non-suppressible by Scer\GAL4^{VP16.nanos.UTR}/Kap-α3^-UTR.UASp

(Virágh et al., 2012)

Enhancer of

Statement

Reference

Fs(2)Ket^RE34 is an enhancer of increased mortality during development | maternal effect phenotype of Pen^D14

(Virágh et al., 2012)

Fs(2)Ket^RE34 is an enhancer of increased mortality during development | maternal effect phenotype of RanGAP^EP1173

(Virágh et al., 2012)

Fs(2)Ket^RE34 is an enhancer of increased mortality during development | maternal effect phenotype of RanGAP^EY21763

(Virágh et al., 2012)

Suppressor of

Statement

Reference

Fs(2)Ket^RE34/Fs(2)Ket[+] is a suppressor | partially of lethal phenotype of Kap-α1^UAS.cMa, Scer\GAL4^e22c

(Ratan et al., 2008)

Other

Statement

Reference

Fs(2)Ket^RE34, Pen^D14 has abnormal mitotic cell cycle | maternal effect | embryonic stage phenotype

(Virágh et al., 2012)

Fs(2)Ket^RE34, Pen^D14 has abnormal developmental rate | maternal effect | embryonic stage phenotype

(Virágh et al., 2012)

Fs(2)Ket^RE34, Pen^D10 has female sterile phenotype

(Erdelyi et al., 1997)

Fs(2)Ket^RE34, Pen^D3 has female sterile phenotype

(Erdelyi et al., 1997)

Fs(2)Ket^RE34, Pen^D14 has female sterile phenotype

(Erdelyi et al., 1997)

Phenotype Manifest In

Suppressor of

Statement

Reference

Fs(2)Ket^RE34/Fs(2)Ket[+] is a suppressor of abdominal tergite phenotype of Kap-α1^UAS.cMa, Scer\GAL4^e22c

(Ratan et al., 2008)

Other

Statement

Reference

Fs(2)Ket^RE34, Pen^D14 has mitotic spindle | maternal effect | embryonic stage phenotype

(Virágh et al., 2012)

Fs(2)Ket^RE34, Pen^D14 has aster | maternal effect | embryonic stage phenotype

(Virágh et al., 2012)

Fs(2)Ket^RE34, Pen^D14 has mitotic spindle microtubule | maternal effect | embryonic stage phenotype

(Virágh et al., 2012)

Fs(2)Ket^RE34, Pen^D14 has nuclear envelope | maternal effect | embryonic stage phenotype

(Virágh et al., 2012)

Fs(2)Ket^RE34, Pen^D14 has spindle pole centrosome | maternal effect | embryonic stage phenotype

(Virágh et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for Fs(2)Ket^RE34 results in a slight increase in the viability of animals expressing Kap-α1^Scer\UAS.cMa under the control of Scer\GAL4^e22c at 25[o]C and results in significantly increased viability of these animals at 27.5[o]C. The defects in tergite morphology are less severe in adult escapers expressing Kap-α1^Scer\UAS.cMa under the control of Scer\GAL4^e22c if they are also heterozygous for Fs(2)Ket^RE34.

(Ratan et al., 2008)

Fs(2)Ket^RE34 Pen double heterozygotes deposit as many eggs as wild type, they look normal but embryogenesis never commences.

(Erdelyi et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Revertant \partial.

(Erdelyi et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Fs(2)Ket^RE34

Ketel^Re34

(Ratan et al., 2008)

imp-betaRE34

(Virágh et al., 2007)

imp-β^KetRE34

(Virágh et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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