Ketel, MRE26, importin-β, imp-β, importin β
Gene model reviewed during 5.47
Large number of splice variants within 3' UTR (most not annotated); correlates with presence of transposable element within 3' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.48
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fs(2)Ket using the Feature Mapper tool.
Western blot analysis reveals that Fs(2)Ket protein is expressed most strongly in embryos, and in the ovaries of adult females, and is expressed at all developmental stages. In third instar larvae, Western analysis detects Fs(2)Ket protein in the imaginal discs, the central nervous system, and faintly in the fat-body. Very little or no expression is observed in the salivary glands, gut, Malpighian tubules, epidermis or muscle. Fs(2)Ket protein is cytoplasmic in all cell types in which it is expressed, and is expressed predominantly in mitotically active cells.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Fs(2)Ket in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Fs(2)Ket CG2637
Expression is enriched in embryonic gonads.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells.
Fs(2)Ket gene product is maternally provided and is required during both embryogenesis and larval life. The gene product is involved in nuclear protein import.
Mutations at the fs(2)lto2 locus cause defects in midoogenesis.
Named for a Hungarian family that vanished by the beginning of the 14th century.