FlyBase Allele Report: Zzzz\poly-PR[25.UAS.Tag:FLAG]

General Information

Symbol

Zzzz\poly-PR^{25.UAS.Tag:FLAG}

Species

a. artificial

Name

FlyBase ID

FBal0352292

Feature type

allele

Associated gene

Zzzz\poly-PR

Associated Insertion(s)

Carried in Construct

PBac{UAS-PR.25.FLAG}

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Boeynaems et al., 2016)

Progenitor genotype

Carried in construct

PBac{UAS-PR.25.FLAG}

Cytology

Description

UASt regulatory sequences drive expression of 25 repeats of Zzzz\poly-PR (dipeptide repeat protein), tagged with Tag:FLAG.

(Boeynaems et al., 2016)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Zzzz\poly-PR

Tagged with

Tag:FLAG

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

CEA

(Boeynaems et al., 2016)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

is ameliorated by Rcc1^KK100628

(Boeynaems et al., 2016)

is ameliorated by Tnpo^KK108990

(Boeynaems et al., 2016)

is ameliorated by Apl^KK115697

(Boeynaems et al., 2016)

is ameliorated by Art1^JF01306

(Boeynaems et al., 2016)

is ameliorated by emb^JF01311

(Boeynaems et al., 2016)

is ameliorated by Art6^GL01070

(Boeynaems et al., 2016)

is ameliorated by Art7^GL01071

(Boeynaems et al., 2016)

is ameliorated by FBXO11^KK100670

(Boeynaems et al., 2016)

is ameliorated by Fs(2)Ket^KK100714

(Boeynaems et al., 2016)

is ameliorated by Impβ11^KK105693

(Boeynaems et al., 2016)

is ameliorated by Kap-α3^KK101268

(Boeynaems et al., 2016)

is exacerbated by Mgtor^KK102690

(Boeynaems et al., 2016)

is ameliorated by Nup107^KK108047

(Boeynaems et al., 2016)

is ameliorated by Nup154^HMS01189

(Boeynaems et al., 2016)

is exacerbated by Nup44A^HMS00736

(Boeynaems et al., 2016)

is ameliorated by Nup50^HMS01054

(Boeynaems et al., 2016)

is exacerbated by Nup62^GLV21060

(Boeynaems et al., 2016)

is exacerbated by Nup93-1^JF01712

(Boeynaems et al., 2016)

is ameliorated by RanGAP^KK102830

(Boeynaems et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Zzzz\poly-PR^{25.UAS.Tag:FLAG}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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