FlyBase Allele Report: Dmel\Nup107[KK108047]

General Information

Symbol

Dmel\Nup107^KK108047

Species

D. melanogaster

Name

FlyBase ID

FBal0259595

Feature type

allele

Associated gene

Dmel\Nup107

Associated Insertion(s)

Carried in Construct

P{KK108047}

Also Known As

Nup107 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108047}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108047

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^58.UAS.EGFP

(Freibaum et al., 2015)

ameliorates frontotemporal dementia

modeled by Zzzz\GGGGCC^58.UAS.EGFP

(Freibaum et al., 2015)

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-PR^{25.UAS.Tag:FLAG}

(Boeynaems et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval salivary gland | larval stage, with Scer\GAL4^Act5C.PI

(Kawadkar et al., 2026)

larval brain, with Scer\GAL4^Act5C.PI

(Kawadkar et al., 2026)

prothoracic gland | larval stage, with Scer\GAL4^phtm.PO

(Kawadkar et al., 2026)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Nup107^KK108047, Scer\GAL4^Act5C.PI has abnormal developmental rate phenotype, suppressible by tor^UASp.cGa, Scer\GAL4^Act5C.PI

(Kawadkar et al., 2026)

Nup107^KK108047, Scer\GAL4^phtm.PO has abnormal developmental rate phenotype, suppressible by tor^UASp.cGa, Scer\GAL4^phtm.PO

(Kawadkar et al., 2026)

Nup107^KK108047, Scer\GAL4^Act5C.PI has abnormal developmental rate phenotype, suppressible by Ras85D^V12.UAS, Scer\GAL4^Act5C.PI

(Kawadkar et al., 2026)

Nup107^KK108047, Scer\GAL4^phtm.PO has abnormal developmental rate phenotype, suppressible by Ras85D^V12.UAS, Scer\GAL4^phtm.PO

(Kawadkar et al., 2026)

Suppressor of

Statement

Reference

Nup107^KK108047, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^58.UAS.EGFP

(Freibaum et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

Nup107^KK108047, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^58.UAS.EGFP

(Freibaum et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Nup107^KK108047 suppresses the rough eye phenotype seen in flies expressing Zzzz\GGGGCC^{58.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.PU.

(Freibaum et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v110759

P{KK108047}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Nup107^110759/KK

(Freibaum et al., 2015)

Nup107^KK108047

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

Open Close