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FB2026_01
,
released March 12, 2026
secreted glycoprotein - fibrinogen family - regulates spacing of photoreceptors - a Notch pathway inhibitory signal secreted by photoreceptor precursors in response to Egfr signaling - transcriptional target of proneural bHLH proteins and a useful marker for proneural regions and cells - contributes to neural patterning
Please see the JBrowse view of Dmel\sca for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
3.2 (northern blot)
774 (aa)
Possesses five pairs of dibasic residues that may be the target of proteolytic processing.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sca using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
sca transcripts are first detected in all cells at the cellular blastoderm stage. By the end of stage 5 a pattern of stripes is seen with a large anterior stripe in the head and seven ventrolateral stripes in the presumptive trunk neurectoderm. By the end of stage 8, expression is seen in 14 segmentally repeated cell clusters in the neurectoderm. In stages 9 and 10, sca is expressed in neuroblasts as they delaminate from the ectoderm and at a reduced level in epidermoblasts. At stage 10, sca is seen in the six longitudinal rows of neuroblasts on either side of the midline. Expression ceases in the segregated neuroblasts by stage 11. sca expression is observed at stage 10 in one cell per parasegment thought to be the P cell. In early stage 11, expression is apparent in an increasing number of SMCs but ceases by stage 12. sca is also expressed in neural precursors along the ventral midline. sca expression is observed transiently in stage 12 in clusters of 8-10 ectodermal cells in the thoracic segments. These may correspond to sense organ precursors in the thoracic segments.
The highest levels of sca transcripts are found in embryos, pupae, and third instar imaginal discs. In embryos, sca transcripts are first detected at 3 hrs of development and by gastrulation, are prominent in the neurogenic ectoderm. During germ band extension, sca transcripts are seen in alternating domains of high and low expression along the anterior-posterior axis. By the early germ band extended stage, expression is restricted to the neurogenic region. During CNS development, expression is higher in neuroblasts than in epidermal precursor cells. Expression is later seen in regions of ectoderm that will give rise to the PNS. In 3rd instar larvae, sca is expressed in the optic lobes, the ventral nerve cord, and in scattered cells in the imaginal discs. Its expression in the eye disc (predominantly in photoreceptor cell R8) and in the wing disc (in sensory bristle precursors) was described in detail.
sca protein is expressed in the sensory mother cells along the dorsal/ventral compartment boundary of the wing disc.
Protein is detected in the intermidiate clusters of the morphogenetic furrow as well as in the posterior single R8 cell precursors. In addition, sca-containing vesicles were detected in cytoplasmic extensions of these sca expressing cells upto ommatidial rows 6-8 corresponding to 15-25 cell diameters. This intracellularly transported sca protein was shown to be important in stopping ommatidial rotation at 90 degrees.
sca protein is first detected in the eye disc in clusters of cells preceding the morphogenetic furrow. It then becomes limited to R8 cell precursors. It remains in R8 cells for about 8 hours, disappearing as overt differentiation begins after the furrow.
JBrowse - Visual display of RNA-Seq signals
View Dmel\sca in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
polyclonal
New stable cell line derived from S2-unspecified : S2 cells were stably transfected with sca-GFP.
sca has a role in the spacing of bristles in the adult notum and may provide cues that allow sensory organ precursors to remain evenly spaced after they have segregated.
sca is not required for inhibition of cells situated adjacent to the bristle precursor cells, but is needed, non-autonomously, for inhibition of cells not adjacent to the precursor.
Two additional alleles have been derived by Δ2-3 mobilization of P{lArB} during an analysis of quantitative trait loci effects on bristle number.
Quantitative differences in the level of sca product plays a role in establishing the spacing pattern within the morphogenetic furrow.
sca appears to be involved in a feedback loop affecting its own transcription in the morphogenetic furrow.
Mutations affect eye morphology.
The pattern of sca transcription during embryogenesis has been analysed.
Mosaic experiments suggest that sca affects the spacing of R8 cells in the eye.
sca is required for the formation of the embryonic nervous system and the generation of the adult eye and sensory bristles.
The sca gene product encodes an inhibitory signal in lateral inhibition during early PNS development in the imaginal discs.
Source for merge of: sca anon- EST:Liang-38
FlyBase curator comment: GS line 2038 ("P{GSV1}scaGS2038") was originally stated to be inserted close to "CG9328" in FBrf0107369. However, this location is incorrect and the insertion has since been mapped to near "sca" (see Aikagi, 2007.3.19, personal communication to FlyBase).
