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Citation
Kaun, K.R., Azanchi, R., Maung, Z., Hirsh, J., Heberlein, U. (2011). A Drosophila model for alcohol reward.  Nat. Neurosci. 14(5): 612--619.
FlyBase ID
FBrf0213574
Publication Type
Research paper
Abstract

The rewarding properties of drugs contribute to the development of abuse and addiction. We developed a new assay for investigating the motivational properties of ethanol in the genetically tractable model Drosophila melanogaster. Flies learned to associate cues with ethanol intoxication and, although transiently aversive, the experience led to a long-lasting attraction for the ethanol-paired cue, implying that intoxication is rewarding. Temporally blocking transmission in dopaminergic neurons revealed that flies require activation of these neurons to express, but not develop, conditioned preference for ethanol-associated cues. Moreover, flies acquired, consolidated and retrieved these rewarding memories using distinct sets of neurons in the mushroom body. Finally, mutations in scabrous, encoding a fibrinogen-related peptide that regulates Notch signaling, disrupted the formation of memories for ethanol reward. Our results thus establish that Drosophila can be useful for understanding the molecular, genetic and neural mechanisms underling the rewarding properties of ethanol.

PubMed ID
PubMed Central ID
PMC4249630 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

5-66a-Gal4 and 4-59-Gal4.
Kaun, 2013.1.31, 5-66a-Gal4 and 4-59-Gal4. [FBrf0224305]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Neurosci.
    Title
    Nature Neuroscience
    Publication Year
    1998-
    ISBN/ISSN
    1097-6256
    Data From Reference