FlyBase Allele Report: Dmel\sca[BP1]

General Information

Symbol

Dmel\sca^BP1

Species

D. melanogaster

Name

FlyBase ID

FBal0032652

Feature type

allele

Associated gene

Dmel\sca

Associated Insertion(s)

P{}sca^BP1

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Hu et al., 1995)

Mutagen

PM hybrid dysgenesis

(Mlodzik et al., 1990)

P-element activity

(Hu et al., 1995)

Progenitor genotype

Associated Insertion(s)

P{}sca^BP1

Cytology

Description

P-element insertion at the transcription start site.

(Hu et al., 1995)

P-element insertion at coordinate 0 of the sca map, at the transcription start site.

(Mlodzik et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:12,780,543..12,780,543

(Thuveson et al., 2019, Hu et al., 1995, Mlodzik et al., 1990)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity (with sca^BP2)

(Chou and Chien, 2002)

Phenotype Manifest In

ommatidium (with sca^BP2)

(Chou and Chien, 2002)

Detailed Description

Statement

Reference

sca^BP1/sca^BP2 eyes and eye discs exhibit significant over-rotation of ommatidia.

(Chou and Chien, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

sca^BP1/sca^BP2 has abnormal planar polarity phenotype, enhanceable by hh[+]/hh^bar3

(Chou and Chien, 2002)

NOT Enhancer of

Statement

Reference

sca[+]/sca^BP1 is a non-enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

NOT Suppressor of

Statement

Reference

sca[+]/sca^BP1 is a non-suppressor of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

sca^BP1/sca^BP2 has ommatidium phenotype, enhanceable by hh[+]/hh^bar3

(Chou and Chien, 2002)

NOT Enhancer of

Statement

Reference

sca[+]/sca^BP1 is a non-enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

NOT Suppressor of

Statement

Reference

sca[+]/sca^BP1 is a non-suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

Additional Comments

Genetic Interactions

Statement

Reference

A sca^BP1/+ background does not affect the Scer\GAL4^hs.2sev>shg^{dCR3h.Scer\UAS.T:Avic\GFP-rs} ommatidial phenotype.

(Mirkovic and Mlodzik, 2006)

S^48-5/sca^BP1 mutants show 9.75%+-3.06 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone.

(Gaengel and Mlodzik, 2003)

The ommatidial rotation phenotype seen in sca^BP1/sca^BP2 eyes and eye discs is dominantly enhanced by hh^bar3.

(Chou and Chien, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Dysgenic reversion of the mutation correlates with loss of P-element sequences. Weak sca allele.

(Mlodzik et al., 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sca-BP1

(Gaengel and Mlodzik, 2003)

sca^BP1

(Thuveson et al., 2019, Mirkovic and Mlodzik, 2006)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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