FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\shgdCR3h.UAS.sgGFP
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General Information
Symbol
Dmel\shgdCR3h.UAS.sgGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0103564
Feature type
allele
Associated gene
Dmel\shg
Associated Insertion(s)
Carried in Construct
P{UAS-dCR3h}
Also Known As
dCR3h
Key Links
Transgenic product class
inframe_deletion
(Oda and Tsukita, 1999)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Oda and Tsukita, 1999)
Mutagen
in vitro construct
(Oda and Tsukita, 1999)
Progenitor genotype
shgUAS.sgGFP
(Oda and Tsukita, 1999)
Carried in construct
P{UAS-dCR3h}
Cytology
Description

Amino acids 339-574 are deleted.

(Oda and Tsukita, 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
shg
Tagged with
sgGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of shgdCR3h.Scer\UAS.T:Avic\GFP-rs in eyes, under the control of Scer\GAL4hs.2sev, causes under-rotation of ommatidia. Photoreceptor loss and patterning defects are minimal in these eyes and planar cell polarity defects are not observed. The ommatidial under-rotation is enhanced in flies with a shgk03401/+, shg1/+ or shg2/+ mutant background. The phenotype is suppressed in Scer\GAL4hs.2sev>shgdCR3h.Scer\UAS.T:Avic\GFP-rs; Scer\GAL4hs.2sev>shgScer\UAS.cSa flies.

      Coexpression of shgΔβ.Scer\UAS with shgdCR3h.Scer\UAS.T:Avic\GFP-rs, under the control of Scer\GAL4hs.2sev, does not rescue the shgdCR3h.Scer\UAS.T:Avic\GFP-rs ommatidial defects. Likewise, coexpression of shgex.Scer\UAS fails to rescue the ommatidial defects.

      (Mirkovic and Mlodzik, 2006)

      When transiently transformed with Scer\GAL4Act5C.PHb into S2 cells, did not promote a cell aggregation phenotype.

      (Oda and Tsukita, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT Enhanced by
      NOT suppressed by
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      NOT suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The Scer\GAL4hs.2sev>shgdCR3h.Scer\UAS.T:Avic\GFP-rs eye phenotype is enhanced in a arm4 background, both in terms of the under-rotation of ommatidia and in defects associated with ommatidial architecture and adhesion, such as the appearance of gaps between the ommatidia. However, an arm2 background does not enhance the Scer\GAL4hs.2sev>shgdCR3h.Scer\UAS.T:Avic\GFP-rs eye phenotype; arm2 does not affect cell architecture in single mutants.

      The under-rotation of ommatidia seen in Scer\GAL4hs.2sev>shgdCR3h.Scer\UAS.T:Avic\GFP-rs eyes is enhanced by coexpression of CadNScer\UAS.cIa.

      Coexpression of Rho1dsRNA.Scer\UAS with shgdCR3h.Scer\UAS.T:Avic\GFP-rs, under the control of Scer\GAL4hs.2sev, enhances the under-rotation of ommatidia seen in Scer\GAL4hs.2sev>shgdCR3h.Scer\UAS.T:Avic\GFP-rs eyes. Similarly, expression of shgdCR3h.Scer\UAS.T:Avic\GFP-rs under the control of Scer\GAL4hs.2sev in a Rho172R/+ background, enhances the ommatidial rotation phenotype of shgdCR3h.Scer\UAS.T:Avic\GFP-rs flies.

      Neither a CadNM19/+ nor a Df(2L)CadNΔ14/+ background affects the Scer\GAL4hs.2sev>shgdCR3h.Scer\UAS.T:Avic\GFP-rs ommatidial phenotype. Likewise, the following genetic backgrounds do not affect the ommatidial phenotype: mys1/+, fz23/+, dsh1/+, stanE59/+, nmoP1/+, scaBP1/+ and rok2/+.

      Both a dgo380/+ and a Vangstbm-6/+ background enhances the ommatidial rotation phenotype of Scer\GAL4hs.2sev>shgdCR3h.Scer\UAS.T:Avic\GFP-rs eyes; a dgo380/+, Vangstbm-6/+ double mutant background further enhances this phenotype.

      (Mirkovic and Mlodzik, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      shgdCR3h.UAS.sgGFP/Scer\GAL4btl.PS partially rescues Df(2R)E2/shg2

      (Oda and Tsukita, 1999)
      Comments

      The addition of shgdCR3h.Scer\UAS.T:Avic\GFP-rs, driven by Scer\GAL4btl.PS, into shg2/Df(2R)E2 flies partially rescues their tracheal fusion phenotype producing incomplete dorsal trunk fusions.

      (Oda and Tsukita, 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in a plasmid and co transfected with Scer\GAL4Act5C.PHb into S2 cells.

      (Oda and Tsukita, 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      shgdCR3h.Scer\UAS.T:Avic\GFP-rs
      shgdCR3h.UAS.rsGFP
      shgdCR3h.UAS.sgGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (3)