FlyBase Allele Report: Dmel\arm[2]

Maternally and zygotically mutant arm² embryos (coming from mothers whose whole germline constitutes from arm² mutant cells only - created by the OvoD germline clone technique) show a segment polarity phenotype and no naked cuticle between denticle belts on the ventral epidermis (resulting in a lawn of denticles).

(Mannava and Tolwinski, 2015)

Denticle belt patterning is abolished in arm² mutants, with all cells secreting a single denticle and having a similar shape, with the planar distribution of markers being uniform around the cell margins.

(Kaplan et al., 2011)

arm² homozygotes exhibit dorsal closure defects characterised by small holes in the dorsal epithelium. Mutant larvae also have a fully penetrant cuticle phenotype, characterised by shortened cuticle, severe segment polarity defects (resulting in a lawn of denticles replacing well-separated denticle belts), a hole in the head region, and a naked cuticle from the anterior end to the third thoracic segment.

arm² heterozygotes do not exhibit a visible phenotype nor a reduction in viability.

(Tikhmyanova et al., 2010)

Embryos mutant for arm² both maternally and zygotically display loss of naked regions of the embryonic cuticle.

(Kaplan et al., 2009)

arm²/Y embryos have a lawn of denticles phenotype.

(Katanaev et al., 2005)

Mutant embryos have a "lawn of denticles" cuticle phenotype.

(Thompson, 2004)

When homozygous mutant germ-line clones are made, embryos exhibit cuticles that are covered with denticles.

(Tolwinski and Wieschaus, 2004)

arm² somatic stem cell (SSC) clones in the ovary are lost more rapidly than wild-type clones. arm² follicle cell clones form large patches similar to those formed by marked wild-type clones. The mutant clones have normal morphology compared to neighbouring wild-type follicle cells.

(Song and Xie, 2003)

When arm² clones are made in the tergites of the adult abdomen, the clone is transformed to form large pleural hairs and cuticle. The polarity of the front of the clone, and of some wild-type cells anterior to the cones is reversed.

(Lawrence et al., 2002)

arm² has no dramatic effect on germline stem cell (GSC) maintenance in the ovary; approximately 60% of mutant GSCs observed during the first week after clone induction are maintained for two more weeks (compared to 70% for controls).

(Song et al., 2002)

The middle gut constriction is missing in mutant embryos.

(Thompson et al., 2002)

Has no effect on the eye phenotype produced by activated arm constructs. (either arm^S44Y.GMR or arm^S56F.GMR).

(Freeman and Bienz, 2001)

Embryos derived from females with arm² homozygous germline clones and carrying Scer\GAL4^arm.PS crossed to males carrying arm^{Δ.Scer\UAS.T:Ivir\HA1} produce embryos with 4 different cuticle phenotypes; small abnormally shaped, denticle covered cuticles (25%, characteristic of arm²), naked cuticles (25%, characteristic of activated arm), wild-type cuticles (25%) and a phenotype where the embryo shows the cell transformations to naked cuticle, but is small and abnormally shaped (25%). This last phenotype seems to be intermediate between the naked and arm² phenotype.

(Tolwinski and Wieschaus, 2001)

arm² embryos dervied from arm² germ-line clones have very few Malpighian tubule cells.

(Ainsworth et al., 2000)

Zygotic arm² mutants show 3 main kinds of tracheal defects; the dorsal trunk (DT) is completely missing or very much reduced, there are no branch fusions and therefore the ten tracheal metameres are completely disconnected and the ganglionic branch is misrouted. The lateral trunk and dorsal branches fail to fuse. The presumptive DT cells invaginate perfectly in mutant embryos, but do not migrate or join with other branches. Most DT cells remain clustered in the position where the DT is normally formed. Embryos derived from homozygous female germline clones show defects in tracheal invagination.

(Llimargas, 2000)

Mutant embryos show dorsal closure defects.

(McEwen et al., 2000)

Embryos maternally and zygotically homozygous for arm² are dramatically reduced in size compared to wild type amd all surviving ventral cells secrete denticles.

(Cox et al., 1999)

Homozygous embryos derived from homozygous female germ line clones have a lawn of denticles phenotype, in which all naked cuticle has been replaced by denticles.

(Gallet et al., 1998)

Embryos zygotically and maternally mutant for arm² show a complete absence of heart precursors.

(Park et al., 1998)

Homozygous clones in the eye are extremely small and only infrequently observed.

(Wehrli and Tomlinson, 1998)

Homozygotes show a weak zygotic segment polarity phenotype that is enhanced to a severe phenotype on removal of the maternal arm⁺ contribution. Hemizygous embryos derived from homozygous female germline clones have a strong segment polarity phenotype.

(White et al., 1998)

Homozygous larvae have denticle lawns composed of large denticles. Homozygous larvae derived from embryos in which spi^s.Scer\UAS is expressed under the control of Scer\GAL4^arm.PS have denticle lawns composed of small denticles.

(Szuts et al., 1997)

Homozygous clones in the eye have interommatidial bristles.

(Cadigan and Nusse, 1996)

In homozygous embryos the second constriction is missing.

(Yu et al., 1996)

Only one central invagination fold of the stomodeal invagination is observed.

(Gonzalez-Gaitan and Jäckle, 1995)

Embryos exhibit a lawn of denticle belts.

(Manoukian et al., 1995)

Embryos lacking both maternal and zygotic sgg and arm function have an embryonic cuticle phenotype like that of arm mutant embryos alone. Embryos lacking maternal sgg and arm but receiving wild type paternal copies develop into normal embryos that survive until adulthood. Embryos lacking maternal sgg and arm but receiving a wild type paternal copy of arm⁺ only, show a sgg naked cuticle phenotype.

(Peifer et al., 1994)

Moderate segment polarity phenotype. Homozygous clones survive at a higher frequency in areas of low wg expression, dorsal regions of the leg disc. Biased distribution is produced by differential survival, not directed migration. Flies carrying one copy of P{arm10.5} survive to late pupal development with a wg-like phenotype.

(Peifer et al., 1991)

Shows effects on segment polarity, head development and dorsal closure. The embryo is slightly shorter than wild type.

(Peifer and Wieschaus, 1990)

Head and dorsal closure defects. Abnormal oogenesis.

(Perrimon and Mahowald, 1987)

Clones of homozygous arm² induced by mitotic recombination form denticles with reversed polarity. Changes in cell fate are autonomous at the level of single cells.

(Wieschaus and Riggleman, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

arm² has segment polarity phenotype | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{KK-MI.UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has segment polarity phenotype | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^UAS.Tag:HA/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has segment polarity phenotype | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

NOT suppressed by

Statement

Reference

arm² has segment polarity phenotype | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{KK-MI.UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has segment polarity phenotype | maternal effect | embryonic stage phenotype, non-suppressible by sgg^UAS.Tag:HA/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has segment polarity phenotype | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

Enhancer of

Statement

Reference

arm² is an enhancer of visible phenotype of Scer\GAL4^en-e16E, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

NOT Enhancer of

Statement

Reference

arm²/arm[+] is a non-enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

arm² is a non-enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

Suppressor of

Statement

Reference

arm²/arm[+] is a suppressor of visible phenotype of Chi^e5.5

(van Tienen et al., 2017)

arm²/arm[+] is a suppressor | partially of abnormal size phenotype of Scer\GAL4^pnr-MD237, hep^UAS.cBa

(Zhang et al., 2015)

arm²/arm[+] is a suppressor | partially of visible phenotype of Scer\GAL4^pnr-MD237, hep^UAS.cBa

(Zhang et al., 2015)

arm²/arm[+] is a suppressor of abnormal size phenotype of Scer\GAL4^GMR.PF, hep^CA.UAS

(Zhang et al., 2015)

arm²/arm[+] is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, hep^CA.UAS

(Zhang et al., 2015)

arm²/arm[+] is a suppressor of increased cell number | female | adult stage | heat sensitive phenotype of Mmp2^Y53N/Mmp2^W307stop

(Wang and Page-McCaw, 2014)

arm² is a suppressor of visible phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

NOT Suppressor of

Statement

Reference

arm²/arm[+] is a non-suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

arm² has denticle field | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has embryonic/larval cuticle | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{KK-MI.UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has denticle field | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{KK-MI.UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has embryonic/larval cuticle | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^UAS.Tag:HA/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has denticle field | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^UAS.Tag:HA/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has embryonic/larval cuticle | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has denticle | ectopic | germline clone phenotype, non-enhanceable by sgg^M11

(Tolwinski and Wieschaus, 2004)

Suppressed by

Statement

Reference

arm² has phenotype, suppressible by eRF1[+]/eRF1^F2

(Chao et al., 2003)

arm² has phenotype, suppressible by sgg^M1-1

(Cox et al., 2000)

arm² has embryonic/larval tracheal dorsal trunk phenotype, suppressible by salm^UAS.cBa/Scer\GAL4^btl.PS

(Llimargas, 2000)

arm² has phenotype, suppressible by Xlae\ctnnb1.L^UAS.cCa/Scer\GAL4^e22c

(Cox et al., 1999)

arm² has embryonic epidermis phenotype, suppressible by pan²

(Cavallo et al., 1998)

arm² has ventral denticle belt phenotype, suppressible by pan²

(Cavallo et al., 1998)

arm² has embryonic epidermis phenotype, suppressible by pan³

(Cavallo et al., 1998)

arm² has ventral denticle belt phenotype, suppressible by pan³

(Cavallo et al., 1998)

arm² has embryonic/first instar larval cuticle phenotype, suppressible by tsh^UAS.cGa/Scer\GAL4^69B

(Gallet et al., 1998)

arm² has embryonic/first instar larval cuticle phenotype, suppressible by Mmus\Ctnnb1^arm.PW

(White et al., 1998)

arm² has embryonic/first instar larval cuticle phenotype, suppressible by Scer\GAL4^arm.PS/Mmus\Ctnnb1^UAS.cWa

(White et al., 1998)

NOT suppressed by

Statement

Reference

arm² has embryonic/larval cuticle | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has embryonic/larval cuticle | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{KK-MI.UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has embryonic/larval cuticle | maternal effect | embryonic stage phenotype, non-suppressible by sgg^UAS.Tag:HA/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has denticle field | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has denticle field | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{KK-MI.UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has denticle field | maternal effect | embryonic stage phenotype, non-suppressible by sgg^UAS.Tag:HA/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

arm² has embryonic/first instar larval cuticle | maternal effect phenotype, non-suppressible by sgg^M11

(Kaplan et al., 2009)

arm² has embryonic/first instar larval cuticle phenotype, non-suppressible by Gαo^GTP.hs

(Katanaev et al., 2005)

arm² has ventral denticle belt phenotype, non-suppressible by Gαo^GTP.hs

(Katanaev et al., 2005)

arm² has denticle | ectopic | germline clone phenotype, non-suppressible by sgg^M11

(Tolwinski and Wieschaus, 2004)

arm² has embryonic/first instar larval cuticle phenotype, non-suppressible by Hsap\JUP^arm.PW

(White et al., 1998)

arm² has embryonic/first instar larval cuticle phenotype, non-suppressible by Scer\GAL4^arm.PS/Hsap\JUP^UAS.cWa

(White et al., 1998)

Enhancer of

Statement

Reference

arm² is an enhancer of wing phenotype of Scer\GAL4^en-e16E, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

arm²/arm[+] is an enhancer of wing phenotype of Scer\GAL4^en-e16E, shg^UAS.cSa

(Waltzer and Bienz, 1998)

NOT Enhancer of

Statement

Reference

arm²/arm[+] is a non-enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

arm² is a non-enhancer of embryonic/first instar larval cuticle | maternal effect phenotype of l(2)gl⁴

(Kaplan et al., 2009)

sgg^M11/arm² is a non-enhancer of embryonic/first instar larval cuticle phenotype of l(2)gl⁴

(Kaplan et al., 2009)

arm² is a non-enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

Suppressor of

Statement

Reference

arm²/arm[+] is a suppressor of wing phenotype of Chi^e5.5

(van Tienen et al., 2017)

arm²/arm[+] is a suppressor | partially of scutellum phenotype of Scer\GAL4^pnr-MD237, hep^UAS.cBa

(Zhang et al., 2015)

arm²/arm[+] is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, hep^CA.UAS

(Zhang et al., 2015)

arm²/arm[+] is a suppressor of stalk follicle cell | increased number | heat sensitive phenotype of Mmp2^Y53N/Mmp2^W307stop

(Wang and Page-McCaw, 2014)

arm² is a suppressor of eye phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

arm² is a suppressor of dorsal tracheal branch primordium phenotype of Dad^UAS.cTa, Scer\GAL4^btl.PS

(Ribeiro et al., 2004)

arm² is a suppressor of ventral denticle belt | anterior phenotype of nej³

(Waltzer and Bienz, 1998)

NOT Suppressor of

Statement

Reference

arm²/arm[+] is a non-suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

arm² is a non-suppressor of embryonic/first instar larval cuticle | maternal effect phenotype of l(2)gl⁴

(Kaplan et al., 2009)

sgg^M11/arm² is a non-suppressor of embryonic/first instar larval cuticle phenotype of l(2)gl⁴

(Kaplan et al., 2009)

arm² is a non-suppressor of ommatidium phenotype of Rac1^V12.hs.sev

(Fanto et al., 2000)

arm² is a non-suppressor of phenotype of dsh^hs.sev.B

(Boutros et al., 1998)

Other

Statement

Reference

arm², arm^S8, sgg^M11 has cuticle | germline clone phenotype

(Tolwinski and Wieschaus, 2004)

arm²/arm^S8, sgg^M11 has cuticle | germline clone phenotype

(Tolwinski and Wieschaus, 2004)

Scer\GAL4^αTub84B.PP, arm², ci^UAS.cAa has embryonic/first instar larval cuticle | germline clone phenotype

(Angelats et al., 2002)

Scer\GAL4^αTub84B.PP, arm², ci^UAS.cAa has mesothoracic ventral denticle belt | germline clone phenotype

(Angelats et al., 2002)

Scer\GAL4^αTub84B.PP, arm², ci^UAS.cAa has metathoracic ventral denticle belt | germline clone phenotype

(Angelats et al., 2002)

Scer\GAL4^αTub84B.PP, arm², ci^UAS.cAa has prothoracic ventral denticle belt | germline clone phenotype

(Angelats et al., 2002)

arm², tkv⁸ has larval tracheal system phenotype

(Llimargas, 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The wing notch phenotype seen in Chi^e5.5/+ mutants is partially suppressed by the presence of arm²/+.

(van Tienen et al., 2017)

The segment polarity phenotype and the lack of naked cuticle between denticle belts, resulting in a lawn of denticles on the ventral epidermis, characteristic for maternally and zygotically mutant arm² embryos is not modified by Scer\GAL4^arm.PU-driven expression of any of the following: sgg^{Scer\UAS.T:Myr-Src64B,T:Ivir\HA1}, sgg^{KK-MI.Scer\UAS.T:Myr-Src64B,T:Ivir\HA1} or sgg^{Scer\UAS.T:Ivir\HA1}.

(Mannava and Tolwinski, 2015)

The increase in average cell number in the stalks between egg chambers which is seen in Mmp2^Y53N/Mmp2^W307stop females after being shifted to the restrictive temperature is dominantly suppressed if the females also carry a single copy of arm².

(Wang and Page-McCaw, 2014)

Approximately 90% of arm²; p130CAS¹ flies exhibit smaller cuticles than arm² mutants. Among these, 82% complete lack cuticle in the head region, and 65% have enhanced posterior curvature suggesting a strong germband retraction phenotype. While 40% of arm² ; p130CAS¹ flies retain the lawn of denticles characteristic of an arm² homozygous mutant, 34% exhibit complete deletion of ventral and dorsal denticle belts, while 36% have well-separated posterior denticle belts.

arm² p130CAS¹ double heterozygotes do not exhibit a visible phenotype nor a reduction in viability.

(Tikhmyanova et al., 2010)

Embryos double mutant for arm² both maternally and zygotically and l(2)gl⁴ zygotically display a cuticle phenotype similar to that of l(2)gl⁴ single mutants.

Cuticles of embryos double mutant maternally and zygotically for both sgg^M11 and arm² resemble that of arm² single mutants.

Embryos triple mutant for sgg^M11 both maternally and zygotically and arm² both maternally and zygotically and l(2)gl⁴ zygotically show a cuticle phenotype that is similar to that of zygotic l(2)gl⁴ single mutants.

(Kaplan et al., 2009)

An arm² background does not enhance the Scer\GAL4^hs.2sev>shg^{dCR3h.Scer\UAS.T:Avic\GFP-rs} eye phenotype; arm² does not affect cell architecture in single mutants.

(Mirkovic and Mlodzik, 2006)

The lawn of denticles phenotype seen in arm²/Y embryos is not affected by expression of G-oα47A^GTP.hs using heat shock.

(Katanaev et al., 2005)

Embryos expressing Dad^Scer\UAS.cTa under the control of Scer\GAL4^btl.PS in an arm² background show outgrowth of the dorsal branches, cell intercalation and autocellular adherens junction formation in the tracheal system.

(Ribeiro et al., 2004)

The addition of sgg^M11 has no effect on the arm² embryonic phenotype. However the combination of arm², arm^S8 and sgg^M11 leads to embryos with naked cuticle.

(Tolwinski and Wieschaus, 2004)

S^48-5/arm² mutants show 12/43%+-5.66 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone.

(Gaengel and Mlodzik, 2003)

The addition of ci^Scer\UAS.cAa (driven by Scer\GAL4^αTub84B.PP) to arm² germ-line clones, can suppress denticle belt formation in the thorax of mutant embryos but not in the abdomen.

(Angelats et al., 2002)

Expression of salm^{Scer\UAS.cdCa} under the control of Scer\GAL4^btl.PS partially rescues the lack of dorsal trunk (DT) seen in the tracheal system of arm² embryos. DT cells are able to migrate anteriorly and posteriorly in these rescued embryos, but the branches do not fuse. The formation of all tracheal branches except the transverse connective and visceral branch is impaired in arm² ; tkv⁸ double mutants.

(Llimargas, 2000)

The lawn of denticles phenotype of arm² embryos derived from arm² female germ line clones is partly suppressed if the embryos are also expressing tsh^Scer\UAS.cGa under the control of Scer\GAL4^69B.

(Gallet et al., 1998)

Dominantly enhances the wing margin phenotype of shg^Scer\UAS.cSa,Scer\GAL4^en-e16E. Reduced denticle belt phenotype of nej³ is suppressed in double mutants with arm².

(Waltzer and Bienz, 1998)

Xenogenetic Interactions

Statement

Reference

Xlae\β-cat^Scer\UAS.cCa partially rescues the phenotype of embryos that are maternally and zygotically mutant for arm², when expressed under the control of Scer\GAL4^e22c.

(Cox et al., 1999)

The segment polarity cuticle phenotype of embryos derived from homozygous arm² female germline clones is partially rescued by Mmus\Catnb^arm.PW and not rescued by Hsap\JUP^arm.PW, when the transgene is provided maternally. The phenotype of these embryos is also partially rescued by Mmus\Catnb^Scer\UAS.cWa expressed under the control of Scer\GAL4^arm.PS and is not rescued by Hsap\JUP^Scer\UAS.cWa expressed under the control of Scer\GAL4^arm.PS.

(White et al., 1998)

Complementation and Rescue Data

Rescued by

arm² is rescued by arm^{Tag:MYC,Tag:PM(hKRAS)}

(Tolwinski and Wieschaus, 2004)

arm² is rescued by Scer\GAL4^arm.PS/arm^{XM19.UAS.Tag:HA}

(Tolwinski and Wieschaus, 2004)

arm² is rescued by arm^+mWa

(White et al., 1998)

arm² is rescued by Scer\GAL4^arm.PS/arm^UAS.cWa

(White et al., 1998)

Partially rescued by

arm² is partially rescued by Scer\GAL4^da.G32/arm^{UAS.Tag:M(sev)}

(Thompson, 2004)

arm² is partially rescued by arm^{UAS.Tag:MYC,Tag:NLS(SV40-largeT)}/Scer\GAL4^e22c

(Cox et al., 1999)

arm² is partially rescued by arm^{UAS.Tag:MYC,Tag:NES(oPKI)}/Scer\GAL4^e22c

(Cox et al., 1999)

arm² is partially rescued by Scer\GAL4^e22c/arm^{R.UAS.Tag:MYC}

(Cox et al., 1999)

arm² is partially rescued by arm^{Tag:MYC,Tag:PM(hKRAS)}

(Cox et al., 1999)

arm² is partially rescued by arm^R.UAS/Scer\GAL4^e22c

(Cox et al., 1999)

arm² is partially rescued by arm^{NR.UAS.Tag:MYC}/Scer\GAL4^e22c

(Cox et al., 1999)

arm² is partially rescued by Scer\GAL4^e22c/arm^{S2.UAS.Tag:MYC}

(Cox et al., 1999)

arm² is partially rescued by Scer\GAL4^arm.PS/arm^ΔC.UAS

(White et al., 1998)

Not rescued by

arm² is not rescued by Scer\GAL4^e22c/arm^{UAS.Tag:MYC,Tag:TM(xNcad)}

(Cox et al., 1999)

arm² is not rescued by Scer\GAL4^e22c/arm^{UAS.Tag:MYC,Tag:TM(xNcad)}

(Cox et al., 1999)

Comments

The "lawn of denticles" cuticle phenotype seen in arm² embryos is substantially rescued by ubiquitous expression of arm^{Scer\UAS.T:sev-TM} using Scer\GAL4^da.G32 (stripes of naked cuticle are restored). Ubiquitous expression of arm^{S10.Scer\UAS.T:Hsap\MYC} in embryos using Scer\GAL4^da.G32 produces ectopic naked cuticle in the arm² background.

(Thompson, 2004)

The segment polarity phenotype of embryos maternally and zygotically mutant for arm² is substantially rescued by arm^{Scer\UAS.T:Hsap\MYC,T:Ocun\nes} or arm^{Scer\UAS.T:Hsap\MYC,T:SV40\nls2} expressed under the control of Scer\GAL4^e22c.

(Cox et al., 1999)

Homozygous clones in the eye that are weakly rescued with arm^BCD7 may show ectopic differentiation of retinal tissue. Many clones are associated with polarity inversions; the clones frequently show polarity inversions on their equatorial side. The polarity inversions are usually contained within the clone, but clones in dorsal regions of the eye show clear non-autonomy, with up to two to four ommatidial rows distant from the clone showing chirality changes.

(Wehrli and Tomlinson, 1998)

The segment polarity cuticle phenotype of embryos derived from homozygous female germline clones is rescued to wild-type by arm^+mWa, when the transgene is provided maternally. The phenotype of these embryos is also rescued by arm^Scer\UAS.cWa expressed under the control of Scer\GAL4^arm.PS and partially rescued by arm^ΔC.Scer\UAS expressed under the control of Scer\GAL4^arm.PS.

(White et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8554

arm² P{FRT(w^hs)}101/FM7a

Notes on Origin

Discoverer

Comments

Encodes a truncated protein that can still be phosphorylated.

(Peifer et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

arm-XM19

(Gaengel and Mlodzik, 2003)

arm^-

(Lawrence et al., 2002)

arm²

(Vuong et al., 2020, Wang and Baker, 2019, Wang and Page-McCaw, 2014, Mathew et al., 2011, Popodi et al., 2010-, Tikhmyanova et al., 2010)

arm^XM19

(Thuveson et al., 2019, Kaur et al., 2017, van Tienen et al., 2017, Mannava and Tolwinski, 2015, Zhang et al., 2015, Sano et al., 2012, Kaplan et al., 2011, Mirkovic et al., 2011, Kaplan et al., 2009, Mirkovic and Mlodzik, 2006, Mosimann et al., 2006, Ribeiro et al., 2004, Thompson, 2004, Tolwinski and Wieschaus, 2004, Bienz and Clevers, 2003, Chao et al., 2003, Tolwinski et al., 2003, Angelats et al., 2002, Franch-Marro and Casanova, 2002, Nakagoshi et al., 2002, Thompson et al., 2002, Freeman and Bienz, 2001, Llimargas and Lawrence, 2001, Tolwinski and Wieschaus, 2001, Ainsworth et al., 2000, Cox et al., 2000, Fanto, 2000, Fanto et al., 2000, Llimargas, 2000, McEwen et al., 2000, Cox et al., 1999, Cox et al., 1999, Gallet et al., 1999, Greaves et al., 1999, Boutros et al., 1998, Cavallo et al., 1998, Gallet et al., 1998, Park et al., 1998, Waltzer and Bienz, 1998, Wehrli and Tomlinson, 1998, White et al., 1998, Riese et al., 1997, Szuts et al., 1997, van de Wetering et al., 1997, Cadigan and Nusse, 1996, Miller and Moon, 1996, Park et al., 1996, Yu et al., 1996, Zecca et al., 1996, Manoukian et al., 1995, Noordermeer et al., 1995, Peifer, 1995, Noordermeer et al., 1994, Peifer et al., 1994, Peifer et al., 1994, Peifer et al., 1993, Riggleman et al., 1989, Perrimon and Mahowald, 1987)

arm[XM19]

(Katanaev et al., 2005)

Name Synonyms

Secondary FlyBase IDs

FBal0049311

References (78)

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