FlyBase Allele Report: Dmel\sgg[M11]

Maternally and zygotically mutant sgg^M11 embryos (coming from mothers whose whole germline constitutes from sgg^M11 mutant cells only - created by the OvoD germline clone technique) show a strong 'naked cuticle' phenotype.

(Mannava and Tolwinski, 2015)

sgg^M11 mutants exhibit a complete loss of embryonic patterning due to hyperactivation of the canonical Wnt pathway, and a completely naked cuticle.

(Kaplan et al., 2011)

Homozygous clones in the wing result in ectopic bristles on the wing blade and margin.

(Quijano et al., 2011)

Embryos mutant for sgg^M11 both maternally and zygotically display naked embryonic cuticle. No cells secrete denticles.

(Kaplan et al., 2009)

Homozygous sgg^M11 germ-line clone-derived embryos display a naked ventral cuticle phenotype.

(Tolwinski, 2009)

sgg^M11 mutant embryos derived from maternal homozygous mutant germ line clones exhibit distinct perturbation of segmentation that is revealed in a loss of all denticles. These embryos do not survive.

(Kalamegham et al., 2007)

sgg^M11 mutant wing blade clones exhibit thin mechanosensory bristles. Ectopic bristles can be generated anywhere on the wing blade by sgg^M11 mutant clones.

(Takaesu et al., 2005)

No denticle are present in the cuticles made by embryos maternally and zygotically mutant for sgg^M11.

(Tolwinski et al., 2003)

Homozygous clones in the wing show transformations of wing blade to wing margin tissue.

(Ahmed et al., 2002)

Mutant stage 17 embryos do not show significant defects in the location or formation of the tracheal dorsal trunk branch, dorsal branch 10, spiracular branch 10 or the posterior spiracle.

(Takaesu et al., 2002)

Homozygous sgg^M11 or sgg³²/sgg^M11 adults (that have been rescued to adulthood by the addition of sgg^hs.P coupled with larval and pupal heatshocks), show a lengthening of the locomotor activity rhythm periodicity to about 26 hours.

(Martinek et al., 2001)

Extra Malpighian tubule cells are specified in sgg^M11 embryos dervied from sgg^M11 germ-line clones.

(Ainsworth et al., 2000)

slou-expressing muscles are often absent in embryos derived from homozygous germline clones.

(Brennan et al., 1999)

In embryos derived from germ line clones, the anterior midgut construction is obliterated. Phenotype is similar to that caused by Apc2 RNAi mutants.

(Yu et al., 1999)

Mutant clones generated via Scer\GAL4^en-e16E and Scer\FLP1^Scer\UAS.cDa acting on P{FRT(w^hs)}101 show ectopic bristles limited to the posterior compartment.

(Duffy et al., 1998)

Embryos do not form ventral denticles.

(Kennerdell and Carthew, 1998)

Embryos zygotically and maternally mutant for sgg^M11 show reduction in the number of heart precursors. sgg^M11 dsh⁷⁵ double mutant embryos have the same phenotype as sgg^M11 single mutant embryos.

(Park et al., 1998)

Females with homozygous germ line clones, mated to wild-type males, give rise to 2 classes of embryos: null sgg^M11/Y embryos (lacking both maternal and zygotic sgg function) which have a completely naked cuticle and paternally rescued sgg^M11/+ embryos (lacking maternal sgg function) which have sparse denticles. These phenotypes are rescued to an almost wild-type denticle pattern by sgg^Scer\UAS.cSa expressed under the control of Scer\GAL4^69B.

(Steitz et al., 1998)

Mutant embryos show abnormal guts.

(Waltzer and Bienz, 1998)

Homozygous clones induced in the eye produce scars. Outside the scarred area, ommatidial chirality is inverted on the polar side of the clone. This phenotype is unchanged if the clone is also homozygous for wg^l-17.

(Wehrli and Tomlinson, 1998)

No effect on the faf eye phenotype.

(Huang and Fischer-Vize, 1996)

Embryos show severe segmentation defects but no increase (but rather a moderate decrease) in heart precursor formation.

(Park et al., 1996)

In paternally rescued embryos the gut constrictions are highly abnormal, all three are condensed and folded up into one giant constriction. Malpighian tubule growth is precociously initiated. Homozygous embryos also exhibit precocious development, but are severely misshapen so morphological analysis is difficult.

(Yu et al., 1996)

More than wild type numbers of invagination folds in the stomodeal invagination are observed.

(Gonzalez-Gaitan and Jäckle, 1995)

Virtually all ventral denticle belts of the embryo are replaced with naked cuticle.

(Manoukian et al., 1995)

Flies lacking both maternal and zygotic sgg have completely naked cuticles, regardless of the dose of ci.

(Motzny and Holmgren, 1995)

Clones induced during the late second larval instar give rise to fully ventralized dorsal bristles in both anterior and posterior compartments.

(Wilder and Perrimon, 1995)

Clones double mutant for sgg^M11 and Df(3R)Espl22 in the anterior wing differentiate anterior bristles (as for clones of sgg^M11 single mutants), however double mutant clones in the posterior compartment differentiate hairs typical of the posterior wing margin.

(de Celis and Ruiz-Gomez, 1995)

Clones of sgg in the wing blade autonomously differentiate tufts of bristles characteristic of the wing margin. Clones of cells simultaneously mutant for both dsh and sgg do not produce a dsh mutant phenotype at the wing margin, but display the phenotype of cells mutant for sgg alone.

(Couso et al., 1994)

Embryos lacking both maternal and zygotic sgg and arm function have an embryonic cuticle phenotype like that of arm mutant embryos alone. Embryos lacking maternal sgg and arm but receiving wild type paternal copies develop into normal embryos that survive until adulthood. Embryos lacking maternal sgg and arm but receiving a wild type paternal copy of arm⁺ only, show a sgg naked cuticle phenotype.

(Peifer et al., 1994)

Embryos derived from homozygous mutant germ lines, receiving neither maternal or zygotic wild type product, lack denticles on the ventral cuticle.

(Siegfried et al., 1994)

Homozygous clones in the wing generally contain dense aggregations of bristles, the type of bristle depending on the location of the clone. The spacing of the normal campaniform sensilla is disrupted if the clone is near the normal location of the sensilla. Ectopic veins are sometimes formed.

(Blair, 1992)

Mutants embryos lacking both maternal and zygotic gene product completely lack ventral denticles: en expression is expanded and there is a strong ectopic wg stripe of expression. Embryos lacking only maternal component have some ventral denticles: en expression is identical to that in the "null" embryos but the ectopic wg stripes are sparse.

(Siegfried et al., 1992)

Hemizygous progeny derived from heterozygous females die during early larval stages. All embryos derived from homozygous germline clones die during embryonic development, and have very poorly differentiated cuticle which sometimes has holes in it. The head is defective, with abnormal spiracles, and the filzkorper material is very prominent. The CNS is very disorganised and the brain often protrudes dorsally rather than being covered by epidermis. The PNS is abnormal. Some embryos have a less extreme phenotype, with more cuticle differentiation and some defective denticle belt differentiation. The phenotype can be partially rescued by a paternal copy of wild-type sgg. Homozygous clones in the wing show homeotic transformation of hairs into bristles.

(Perrimon and Smouse, 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

sgg^M11 has abnormal planar polarity phenotype, enhanceable by arm^F1α/aPKC^k06403

(Kaplan et al., 2011)

sgg^M11 has abnormal cell polarity phenotype, enhanceable by arm^F1α/aPKC^k06403

(Kaplan et al., 2011)

arm^F1α, sgg^M11 has abnormal planar polarity phenotype, enhanceable by Scer\GAL4^da.G32/aPKC^ΔN.UAS

(Kaplan et al., 2011)

arm^F1α, sgg^M11 has abnormal cell polarity phenotype, enhanceable by Scer\GAL4^da.G32/aPKC^ΔN.UAS

(Kaplan et al., 2011)

sgg^M11 has abnormal planar polarity phenotype, enhanceable by arm^F1α/Scer\GAL4^da.G32/aPKC^ΔN.UAS

(Kaplan et al., 2011)

sgg^M11 has abnormal cell polarity phenotype, enhanceable by arm^F1α/Scer\GAL4^da.G32/aPKC^ΔN.UAS

(Kaplan et al., 2011)

Suppressed by

Statement

Reference

sgg^M11 has abnormal planar polarity phenotype, suppressible by arm^F1α

(Kaplan et al., 2011)

sgg^M11 has abnormal cell polarity phenotype, suppressible by arm^F1α

(Kaplan et al., 2011)

sgg^M11 has visible | recessive | germline clone | maternal effect | embryonic stage phenotype, suppressible by Scer\GAL4^arm.PS/gskt^UAS.cKa

(Kalamegham et al., 2007)

Enhancer of

Statement

Reference

sgg^M11/arm^F1α is an enhancer of abnormal planar polarity phenotype of aPKC^k06403

(Kaplan et al., 2011)

sgg^M11/arm^F1α is an enhancer of abnormal cell polarity phenotype of aPKC^k06403

(Kaplan et al., 2011)

sgg^M11/aPKC^k06403 is an enhancer of abnormal planar polarity phenotype of arm^F1α

(Kaplan et al., 2011)

sgg^M11/aPKC^k06403 is an enhancer of abnormal cell polarity phenotype of arm^F1α

(Kaplan et al., 2011)

sgg^M11 is an enhancer of abnormal planar polarity phenotype of aPKC^k06403, arm^F1α

(Kaplan et al., 2011)

sgg^M11 is an enhancer of abnormal cell polarity phenotype of aPKC^k06403, arm^F1α

(Kaplan et al., 2011)

sgg^M11/sgg[+] is an enhancer of visible phenotype of Scer\GAL4^en-e16E, arm^UAS.cWa

(Greaves et al., 1999)

sgg^M11 is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, arm^UAS.cWa

(Greaves et al., 1999)

NOT Enhancer of

Statement

Reference

sgg^M11 is a non-enhancer of visible phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

Suppressor of

Statement

Reference

sgg^M11 is a suppressor of visible phenotype of Scer\GAL4^unspecified, nkd^UAS.cZa

(Zeng et al., 2000)

sgg^M11/sgg[+] is a suppressor of visible phenotype of Scer\GAL4^en-e16E, arm^UAS.cWa

(Greaves et al., 1999)

sgg^M11 is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

sgg^M11 is a suppressor of visible phenotype of Scer\GAL4^en-e16E, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

sgg^M11 is a suppressor of visible phenotype of Scer\GAL4^69B, fz^UAS.N

(Zhang and Carthew, 1998)

NOT Suppressor of

Statement

Reference

sgg^M11 is a non-suppressor of abnormal planar polarity phenotype of arm^F1α

(Kaplan et al., 2011)

sgg^M11 is a non-suppressor of abnormal cell polarity phenotype of arm^F1α

(Kaplan et al., 2011)

sgg^M11 is a non-suppressor of lethal | segment polarity expression pattern | germline clone | larval stage phenotype of lgs^20F

(Kramps et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

sgg^M11 has ventral denticle belt phenotype, enhanceable by arm^F1α/aPKC^k06403

(Kaplan et al., 2011)

arm^F1α, sgg^M11 has ventral denticle belt phenotype, enhanceable by Scer\GAL4^da.G32/aPKC^ΔN.UAS

(Kaplan et al., 2011)

sgg^M11 has ventral denticle belt phenotype, enhanceable by arm^F1α/Scer\GAL4^da.G32/aPKC^ΔN.UAS

(Kaplan et al., 2011)

NOT Enhanced by

Statement

Reference

sgg^M11 has ventral denticle belt | germline clone phenotype, non-enhanceable by Apc2^UAS.GFP/Scer\GAL4^da.G32

(Tolwinski, 2009)

sgg^M11 has ventral denticle belt | germline clone phenotype, non-enhanceable by Apc2^{UAS.Tag:Myr(Src64B),Tag:FLAG}/Scer\GAL4^da.G32

(Tolwinski, 2009)

Suppressed by

Statement

Reference

sgg^M11 has ventral denticle belt phenotype, suppressible by arm^F1α

(Kaplan et al., 2011)

sgg^M11 has ventral denticle belt | germline clone phenotype, suppressible by Axn^UAS.cHa/Scer\GAL4^da.G32

(Tolwinski, 2009)

sgg^M11 has ventral denticle belt | germline clone phenotype, suppressible by Axn^{UAS.Tag:Myr(Src64B),Tag:FLAG}/Scer\GAL4^da.G32

(Tolwinski, 2009)

sgg^M11 has ventral denticle belt | germline clone | maternal effect phenotype, suppressible by Scer\GAL4^arm.PS/gskt^UAS.cKa

(Kalamegham et al., 2007)

sgg^M11 has ventral denticle belt | germline clone | rescuable maternal effect phenotype, suppressible by arm⁸

(Tolwinski et al., 2003)

sgg^M11 has embryonic/first instar larval cuticle | germline clone | rescuable maternal effect phenotype, suppressible by arm⁸

(Tolwinski et al., 2003)

sgg^M11 has embryonic/first instar larval cuticle | germline clone | rescuable maternal effect phenotype, suppressible by arm^F1α

(Tolwinski et al., 2003)

sgg^M11 has ventral denticle belt | germline clone | rescuable maternal effect phenotype, suppressible by arm^F1α

(Tolwinski et al., 2003)

NOT suppressed by

Statement

Reference

sgg^M11 has ventral denticle belt | germline clone phenotype, non-suppressible by Apc2^UAS.GFP/Scer\GAL4^da.G32

(Tolwinski, 2009)

sgg^M11 has ventral denticle belt | germline clone phenotype, non-suppressible by Apc2^{UAS.Tag:Myr(Src64B),Tag:FLAG}/Scer\GAL4^da.G32

(Tolwinski, 2009)

sgg^M11 has abdominal 1 ventral denticle belt phenotype, non-suppressible by dsh³

(Siegfried et al., 1994)

sgg^M11 has abdominal 2 ventral denticle belt phenotype, non-suppressible by dsh³

(Siegfried et al., 1994)

sgg^M11 has abdominal 3 ventral denticle belt phenotype, non-suppressible by dsh³

(Siegfried et al., 1994)

sgg^M11 has abdominal 4 ventral denticle belt phenotype, non-suppressible by dsh³

(Siegfried et al., 1994)

sgg^M11 has abdominal 5 ventral denticle belt phenotype, non-suppressible by dsh³

(Siegfried et al., 1994)

sgg^M11 has abdominal 6 ventral denticle belt phenotype, non-suppressible by dsh³

(Siegfried et al., 1994)

sgg^M11 has abdominal 7 ventral denticle belt phenotype, non-suppressible by dsh³

(Siegfried et al., 1994)

sgg^M11 has abdominal 1 ventral denticle belt phenotype, non-suppressible by por^PB16

(Siegfried et al., 1994)

sgg^M11 has abdominal 2 ventral denticle belt phenotype, non-suppressible by por^PB16

(Siegfried et al., 1994)

sgg^M11 has abdominal 3 ventral denticle belt phenotype, non-suppressible by por^PB16

(Siegfried et al., 1994)

sgg^M11 has abdominal 4 ventral denticle belt phenotype, non-suppressible by por^PB16

(Siegfried et al., 1994)

sgg^M11 has abdominal 5 ventral denticle belt phenotype, non-suppressible by por^PB16

(Siegfried et al., 1994)

sgg^M11 has abdominal 6 ventral denticle belt phenotype, non-suppressible by por^PB16

(Siegfried et al., 1994)

sgg^M11 has abdominal 7 ventral denticle belt phenotype, non-suppressible by por^PB16

(Siegfried et al., 1994)

Enhancer of

Statement

Reference

sgg^M11 is an enhancer of ventral denticle belt phenotype of aPKC^k06403, arm^F1α

(Kaplan et al., 2011)

sgg^M11/arm^F1α is an enhancer of ventral denticle belt phenotype of aPKC^k06403

(Kaplan et al., 2011)

sgg^M11/aPKC^k06403 is an enhancer of ventral denticle belt phenotype of arm^F1α

(Kaplan et al., 2011)

sgg^M11/sgg[+] is an enhancer of wing sensillum | ectopic phenotype of Scer\GAL4^en-e16E, arm^UAS.cWa

(Greaves et al., 1999)

sgg^M11 is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, arm^UAS.cWa

(Greaves et al., 1999)

sgg^M11 is an enhancer of embryonic/larval midgut | embryonic stage phenotype of nej³

(Waltzer and Bienz, 1998)

NOT Enhancer of

Statement

Reference

sgg^M11/arm² is a non-enhancer of embryonic/first instar larval cuticle phenotype of l(2)gl⁴

(Kaplan et al., 2009)

sgg^M11/arm^F1α is a non-enhancer of embryonic/first instar larval cuticle phenotype of l(2)gl⁴

(Kaplan et al., 2009)

sgg^M11 is a non-enhancer of embryonic/first instar larval cuticle phenotype of l(2)gl⁴

(Kaplan et al., 2009)

sgg^M11 is a non-enhancer of embryonic/first instar larval cuticle | maternal effect phenotype of arm^F1α

(Kaplan et al., 2009)

sgg^M11 is a non-enhancer of denticle | ectopic | germline clone phenotype of arm²

(Tolwinski and Wieschaus, 2004)

Suppressor of

Statement

Reference

sgg^M11 is a suppressor of embryonic leading edge cell | germline clone | maternal effect phenotype of dsh³

(Morel and Arias, 2004)

sgg^M11 is a suppressor of embryonic/first instar larval cuticle | germline clone | maternal effect phenotype of dsh³

(Morel and Arias, 2004)

sgg^M11/sgg[+] is a suppressor of scutellar bristle phenotype of Scer\GAL4^ap-md544, nmo^c5-1.UAS

(Zeng and Verheyen, 2004)

sgg^M11/sgg[+] is a suppressor of scutum & macrochaeta phenotype of Scer\GAL4^ap-md544, nmo^c5-1.UAS

(Zeng and Verheyen, 2004)

sgg^M11/sgg[+] is a suppressor | partially of wing phenotype of Scer\GAL4^ap-md544, nmo^c5-1.UAS

(Zeng and Verheyen, 2004)

sgg^M11/sgg[+] is a suppressor of wing margin phenotype of Scer\GAL4^sd-SG29.1, nmo^c5-1.UAS

(Zeng and Verheyen, 2004)

sgg^M11 is a suppressor of wing disc | ectopic phenotype of Pka-C1^E95, smo³

(Price and Kalderon, 2002)

sgg^M11 is a suppressor | somatic clone of macrochaeta phenotype of N^{ECNΔ10-12.UAS}, Scer\GAL4^ptc-559.1

(Brennan et al., 1999)

sgg^M11 is a suppressor | somatic clone of proneural cluster & dorsal mesothoracic disc phenotype of N^{ECNΔ10-12.UAS}, Scer\GAL4^ptc-559.1

(Brennan et al., 1999)

sgg^M11/sgg[+] is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^en-e16E, arm^UAS.cWa

(Greaves et al., 1999)

sgg^M11 is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

sgg^M11 is a suppressor of wing phenotype of Scer\GAL4^en-e16E, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

NOT Suppressor of

Statement

Reference

sgg^M11 is a non-suppressor of ventral denticle belt phenotype of arm^F1α

(Kaplan et al., 2011)

sgg^M11 is a non-suppressor of embryonic/first instar larval cuticle | maternal effect phenotype of arm²

(Kaplan et al., 2009)

sgg^M11 is a non-suppressor of embryonic/first instar larval cuticle | maternal effect phenotype of arm^F1α

(Kaplan et al., 2009)

sgg^M11/arm² is a non-suppressor of embryonic/first instar larval cuticle phenotype of l(2)gl⁴

(Kaplan et al., 2009)

sgg^M11/arm^F1α is a non-suppressor of embryonic/first instar larval cuticle phenotype of l(2)gl⁴

(Kaplan et al., 2009)

sgg^M11 is a non-suppressor of embryonic/first instar larval cuticle phenotype of l(2)gl⁴

(Kaplan et al., 2009)

sgg^M11 is a non-suppressor of denticle | ectopic | germline clone phenotype of arm²

(Tolwinski and Wieschaus, 2004)

sgg^M11 is a non-suppressor of mesonotum | ectopic phenotype of Pka-C1^E95, smo³

(Price and Kalderon, 2002)

Other

Statement

Reference

arm²/arm^S8, sgg^M11 has cuticle | germline clone phenotype

(Tolwinski and Wieschaus, 2004)

arm², arm^S8, sgg^M11 has cuticle | germline clone phenotype

(Tolwinski and Wieschaus, 2004)

Additional Comments

Genetic Interactions

Statement

Reference

arm^F1α; sgg^M11 double mutants exhibit normal denticle development. Expression of aPKC^ΔN.Scer\UAS under the control of Scer\GAL4^da.G32 in these double mutants display randomly oriented denticles. Cells secreting denticles are not rectangular or aligned in regular rows. This effect is specific to sgg^M11 mutants as neither expression of aPKC^ΔN.Scer\UAS in otherwise wild-type embryos, nor in arm^F1α mutant embryos show an effect on denticle organisation.

A sgg^M11 mutant background fails to affect the epithelial patterning defects found in arm^F1α mutants.

arm^F1α; sgg^M11; aPKC^k06403 triple mutants exhibit significant denticle and cell disruption. Specifically, proper cell shapes and cell alignment are lost, and instead of organization into even rows, cells curved and formed denticle swirls.

(Kaplan et al., 2011)

Cuticles of embryos double mutant maternally and zygotically for both sgg^M11 and arm² resemble that of arm² single mutants.

Embryos triple mutant for sgg^M11 both maternally and zygotically and arm² both maternally and zygotically and l(2)gl⁴ zygotically show a cuticle phenotype that is similar to that of zygotic l(2)gl⁴ single mutants.

Cuticles of embryos double mutant maternally and zygotically for arm^F1α and sgg^M11 resemble that of arm^F1α single mutant embryos.

Embryos triple mutant for sgg^M11 both maternally and zygotically and arm^F1α both maternally and zygotically and l(2)gl⁴ zygotically show a cuticle phenotype that is similar to that of zygotic l(2)gl⁴ single mutants.

Cuticles of embryos double mutant for sgg^M11 both maternally and zygotically and l(2)gl⁴ zygotically resemble that of l(2)gl⁴ single mutants.

(Kaplan et al., 2009)

Expression of Axn^Scer\UAS.cHa under the control of Scer\GAL4^da.G32 suppresses the ventral denticle belt phenotype of sgg^M11 mutant embryos.

Expression of Axn^{Scer\UAS.T:Src64B,T:Zzzz\FLAG} under the control of Scer\GAL4^da.G32 weakly suppresses the ventral denticle belt phenotype of sgg^M11 mutant embryos.

Expression of Apc2^{Scer\UAS.T:Avic\GFP} has no effect on the ventral denticle belt phenotype of sgg^M11 mutant embryos.

Expression of Apc2^{Scer\UAS.T:Src64B,T:Zzzz\FLAG} has no effect on the ventral denticle belt phenotype of sgg^M11 mutant embryos.

(Tolwinski, 2009)

Zygotic expression of gskt^Scer\UAS.cKa driven by Scer\GAL4^arm.PS in maternal mutant sgg^M11 embryos partially restores segmentation.

(Kalamegham et al., 2007)

Unlike embryos from dsh³ germline clones, embryos from dsh³; sgg^M11 germ-line clones have no dorsal hole in their cuticles (although their dorsal cuticle is severely puckered), and have a dorso-ventrally polarised and extended leading edge at stage 13.

(Morel and Arias, 2004)

The addition of sgg^M11 has no effect on the arm² embryonic phenotype. However the combination of arm², arm^S8 and sgg^M11 leads to embryos with naked cuticle.

(Tolwinski and Wieschaus, 2004)

Notching of the distal wing margin in nmo^{c5-1.Scer\UAS}; Scer\GAL4^sd-SG29.1 flies is completely suppressed by sgg^M11/+. Loss of notum macrochaetae in nmo^{c5-1.Scer\UAS}; Scer\GAL4^ap-md544 flies is suppressed by sgg^M11/+ and enhanced by Axn^A2.Scer\UAS, leading to the loss of all scutellar bristles. Severe blistering of the wing in nmo^{c5-1.Scer\UAS}; Scer\GAL4^ap-md544 flies is suppressed by sgg^M11/+, resulting in almost wild-type wings.

(Zeng and Verheyen, 2004)

The loss of denticle belts in the cuticle made by sgg^M11/sgg^M11 maternal/zygotic mutant embryos, is suppressed by maternal/zygotic arm^F1α/arm^F1α (a weaker suppression is seen when arm⁸ is used instead). When these double mutant embryos are also zygotically mutant for wg^l-8, they make little naked cuticle, a phenotype approximating to that seen in wg^l-8 mutants. The appearance of the denticle lawn in these embryos is noticeably different to that seen in maternal/zygotic arm^F1α/arm^F1α embryos zygotically mutant for wg^l-8. The denticle belts formed in sgg^M11; arm^F1α maternal/zygotic double mutant embryos are largely suppressed by Axn^S044230/Axn^S044230, leaving mainly naked cuticle without much sign of periodic character. The periodic character of the cuticles made by sgg^M11; arm⁸ maternal/zygotic double mutant embryos is suppressed by arr²/arr², with the resulting cuticle tending toward denticle cell fates.

(Tolwinski et al., 2003)

lgs^20F, sgg^M11 homozygous mutant germ-line clones can made by rescuing homozygous mothers with P{αTub84B(FRT.lgs.sgg)Scer\GAL4.B} and FLPing out sgg^mR10 and lgs^αTub84B.PK (Which are surrounded by FRT sites). When this is done, the phenotype of the animals is indistinguishable from lgs^20F germ-line clones.

(Kramps et al., 2002)

Pka-C1^E95, sgg^M11 smo³ triple mutant clones in the wing disc exhibit some outgrowths from the notum but no significant wing pattern duplications.

(Price and Kalderon, 2002)

sgg^M11 somatic clones, in a N^{ECNΔ10-12.Scer\UAS}/Scer\GAL4^ptc-559.1 background, suppress the loss of proneural precursors and sensory organ phenotypes normally seen in these flies.

(Brennan et al., 1999)

Has no effect on the wing nicking phenotype seen in mam^N.Scer\UAS, Scer\GAL4^C96 flies.

(Helms et al., 1999)

The sgg^M11 lack of denticles phenotype is not affected by injection of both dsRNA produced by annealing fz^374-2360 and fz^a.374-2360 RNA and dsRNA produced by annealing fz2^L.cKa and fz2^a.L.cKa RNA.

(Kennerdell and Carthew, 1998)

Double mutants for sgg^M11 and nej³ show a worse gut phenotype than do nej³ single mutants.

(Waltzer and Bienz, 1998)

Suppresses wing margin phenotype of fz^Scer\UAS.N, Scer\GAL4^69B.

(Zhang and Carthew, 1998)

Embryos doubly mutant for sgg^M11 and dsh³ or por^PB16 also lack denticles on the ventral cuticle. Embryos doubly mutant for sgg^M11 and arm⁸ display the ventral cuticle covered with denticles.

(Siegfried et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

sgg^M11 is rescued by sgg^mR10

(Ruel et al., 1993)

sgg^M11 is rescued by sgg^A.hs

(Siegfried et al., 1992)

Partially rescued by

sgg^M11 is partially rescued by sgg^UAS.Tag:HA/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

sgg^M11 is partially rescued by sgg^UAS.cSa/Scer\GAL4^arm.PS

(Kalamegham et al., 2007)

sgg^M11 is partially rescued by sgg^UAS.cSa/Scer\GAL4^69B

(Steitz et al., 1998)

Not rescued by

sgg^M11 is not rescued by sgg^{UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

sgg^M11 is not rescued by sgg^{KK-MI.UAS.Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

sgg^M11 is not rescued by sgg^{KK-MI.UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

Comments

The naked cuticle phenotype characteristic for both maternally and zygotically sgg^M11 mutant embryos cannot be rescued by Scer\GAL4^arm.PU-driven expression of any of the following: sgg^{KK-MI.Scer\UAS.T:Ivir\HA1}, sgg^{Scer\UAS.T:Myr-Src64B,T:Ivir\HA1}, sgg^{KK-MI.Scer\UAS.T:Myr-Src64B,T:Ivir\HA1} but is partially rescued by co-expression of sgg^{Scer\UAS.T:Ivir\HA1}.

(Mannava and Tolwinski, 2015)

Zygotic expression of sgg^Scer\UAS.cSa driven by Scer\GAL4^arm.PS in maternal mutant sgg^M11 embryos partially restores segmentation.

Zygotic expression of gskt^Scer\UAS.cKa driven by Scer\GAL4^arm.PS in maternal mutant sgg^M11 embryos partially restores segmentation. The extent of sgg^M11 mutant rescue by gskt^Scer\UAS.cKa is less than the rescue by sgg^Scer\UAS.cSa.

(Kalamegham et al., 2007)

sgg^mR10 rescues hemizygous males to viable and (poorly) fertile adults.

(Ruel et al., 1993)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Strong sgg allele.

(Cadigan and Nusse, 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

sgg³³

sgg^M11-1

(Kalamegham et al., 2007, Shirras and Couso, 1996, Gonzalez-Gaitan and Jäckle, 1995, Couso et al., 1994, Ruel et al., 1993, Siegfried et al., 1992)

sgg^M11

(Banerjee et al., 2021, Sato and Shibuya, 2018, Yang et al., 2012, Metcalfe et al., 2010, Zheng and Sehgal, 2010)

sgg^MX11

(Gallet et al., 1999)

sgg^m11.1

(de Celis and Ruiz-Gomez, 1995)

sgg^m11

(Hayward et al., 2005, Brennan et al., 1999, Brennan et al., 1999, Blair, 1992)

zw3/sgg^m11

(Leviten and Posakony, 1996)

zw3^M11

(Quijano et al., 2011, Tolwinski, 2009, Takaesu et al., 2005, Nakagoshi et al., 2002, Takaesu et al., 2002, Ainsworth et al., 2000, Zeng et al., 2000, Greaves et al., 1999, Cadigan et al., 1998, Duffy et al., 1998, Park et al., 1998, Waltzer and Bienz, 1998, Yu et al., 1998, Cadigan and Nusse, 1996, Park et al., 1996, Manoukian et al., 1995, Wilder and Perrimon, 1995)

zw3^m11-1

(Price and Kalderon, 2002)

zw3^m11

(Zeng and Verheyen, 2004, Zhang and Carthew, 1998, Blair, 1994)

Name Synonyms

Secondary FlyBase IDs

References (69)

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