FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sggUAS.Tag:Myr(Src64B),Tag:HA
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General Information
Symbol
Dmel\sggUAS.Tag:Myr(Src64B),Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0324778
Feature type
allele
Associated gene
Dmel\sgg
Associated Insertion(s)
Carried in Construct
P{UAS-myr-sgg.3xHA}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Mannava and Tolwinski, 2015)
Progenitor genotype
Carried in construct
P{UAS-myr-sgg.3xHA}
Cytology
Description

UAS regulatory sequences drive expression of sgg that is tagged at the N-terminal end with the Tag:Myr(Src64B) membrane targeting sequence, and at the C-terminal end with 3 copies of Tag:HA.

(Mannava and Tolwinski, 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
sgg
Tagged with
Tag:HA
Tag:Myr(Src64B)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos from mothers that express sggScer\UAS.T:Myr-Src64B,T:Ivir\HA1 under the control of Scer\GAL4arm.PU display defects in the ventral cuticle patterning - loss of denticle belts (the naked cuticle phenotype).

      (Mannava and Tolwinski, 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The segment polarity phenotype and the lack of naked cuticle between denticle belts, resulting in a lawn of denticles on the ventral epidermis, characteristic for maternally and zygotically mutant arm2 or armF1α or arr2 or dsh3 embryos is not modified by Scer\GAL4arm.PU-driven (or Scer\GAL4da.PU-driven, in the arr2 mutants) expression of sggScer\UAS.T:Myr-Src64B,T:Ivir\HA1.

      The naked cuticle phenotype (loss of denticle belts on the ventral epidermis) characteristic for embryos expressing sggScer\UAS.T:Myr-Src64B,T:Ivir\HA1 under the control of Scer\GAL4arm.PU is not affected by combination with wgl-8 homozygosity (which on its own leads to loss of naked cuticle and ectopic denticles).

      Scer\GAL4arm.PU-driven expression of sggScer\UAS.T:Myr-Src64B,T:Ivir\HA1 can mildly rescue cuticle integrity in arm043A01 maternally and zygotically mutant arm043A01 embryos.

      (Mannava and Tolwinski, 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      sggUAS.Tag:Myr(Src64B),Tag:HA/Scer\GAL4arm.PU fails to rescue sggM11

      (Mannava and Tolwinski, 2015)
      Comments

      The naked cuticle phenotype characteristic for both maternally and zygotically mutant sggM11 embryos cannot be rescued by expression of sggScer\UAS.T:Myr-Src64B,T:Ivir\HA1 controlled by Scer\GAL4arm.PU.

      (Mannava and Tolwinski, 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sggScer\UAS.T:Myr-Src64B,T:Ivir\HA1
      sggUAS.Tag:Myr(Src64B),Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)