FlyBase Allele Report: Dmel\pan[3]

General Information

Symbol

Dmel\pan³

Species

D. melanogaster

Name

FlyBase ID

FBal0059981

Feature type

allele

Associated gene

Dmel\pan

Associated Insertion(s)

Carried in Construct

Also Known As

dTCF³

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(van de Wetering et al., 1997)

Mutagen

Progenitor genotype

Cytology

Description

Nucleotide substitution: C?T.

(van de Wetering et al., 1997)

Amino acid replacement: Q319term.

(van de Wetering et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

4:94,861..94,861 [+]

Nucleotide change:

C94861T

Reported nucleotide change:

C?T

Amino acid change:

Reported amino acid change:

Q319term

(van de Wetering et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Dupont et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(4)ED6366)

(Weasner et al., 2025)

lethal (with Df(4)ED6369)

(Weasner et al., 2025)

lethal (with Df(4)M101-62f)

(Weasner et al., 2025)

lethal (with pan^I)

(Weasner et al., 2025)

lethal - all die during embryonic stage | recessive

(Cavallo et al., 1998)

some die during embryonic stage | recessive

(Cavallo et al., 1998)

Phenotype Manifest In

embryonic/first instar larval cuticle

(Metcalfe et al., 2010, Gallet et al., 1998)

embryonic epidermis

(Cavallo et al., 1998)

segment

(van de Wetering et al., 1997)

ventral denticle belt

(Metcalfe et al., 2010, Cavallo et al., 1998)

Detailed Description

Statement

Reference

pan³ mutant embryos exhibit a denticle lawn phenotype.

(Metcalfe et al., 2010)

Strongly suppresses the eye phenotype produced by activated arm constructs. (either arm^S44Y.GMR or arm^S56F.GMR).

(Freeman and Bienz, 2001)

Homozygous embryos resemble wg^l-17 pan³ double mutants.

(Cavallo et al., 1998)

The lawn of denticles phenotype of pan³ embryos is replaced by naked cuticle if the embryos are also expressing tsh^Scer\UAS.cGa under the control of Scer\GAL4^69B.

(Gallet et al., 1998)

Regions of naked cuticle are replaced by cuticle with denticles. Head segments are relatively unaffected.

(van de Wetering et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

pan[+]/pan³ is a suppressor of visible phenotype of Chi^e5.5

(van Tienen et al., 2017)

pan[+]/pan³ is a suppressor | partially of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Dupont et al., 2012)

pan[+]/pan³ is a suppressor | partially of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR

(Dupont et al., 2012)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

pan³ has ventral denticle belt phenotype, non-enhanceable by Scer\GAL4^arm.PS/arr::dsh^{DIX-ctail.UAS}

(Metcalfe et al., 2010)

pan³ has embryonic/first instar larval cuticle phenotype, non-enhanceable by Scer\GAL4^arm.PS/arr::dsh^{DIX-ctail.UAS}

(Metcalfe et al., 2010)

pan³ has phenotype, non-enhanceable by Apc2^ΔS

(McCartney et al., 1999)

NOT suppressed by

Statement

Reference

pan³ has ventral denticle belt phenotype, non-suppressible by Scer\GAL4^arm.PS/arr::dsh^{DIX-ctail.UAS}

(Metcalfe et al., 2010)

pan³ has embryonic/first instar larval cuticle phenotype, non-suppressible by Scer\GAL4^arm.PS/arr::dsh^{DIX-ctail.UAS}

(Metcalfe et al., 2010)

pan³ has phenotype, non-suppressible by Apc2^ΔS

(McCartney et al., 1999)

NOT Enhancer of

Statement

Reference

pan³, Scer\GAL4^30A is a non-enhancer of wing phenotype of Pka-C1^UAS.cKa, Scer\GAL4^30A

(Kiger et al., 2001)

Suppressor of

Statement

Reference

pan[+]/pan³ is a suppressor of wing phenotype of Chi^e5.5

(van Tienen et al., 2017)

pan³ is a suppressor of embryonic epidermis phenotype of arm³

(Cavallo et al., 1998)

pan³ is a suppressor of ventral denticle belt phenotype of arm³

(Cavallo et al., 1998)

pan³ is a suppressor of embryonic epidermis phenotype of arm⁴

(Cavallo et al., 1998)

pan³ is a suppressor of ventral denticle belt phenotype of arm⁴

(Cavallo et al., 1998)

pan³ is a suppressor of embryonic epidermis phenotype of wg^l-17

(Cavallo et al., 1998)

pan³ is a suppressor of ventral denticle belt phenotype of wg^l-17

(Cavallo et al., 1998)

pan³ is a suppressor of embryonic epidermis phenotype of arm²

(Cavallo et al., 1998)

pan³ is a suppressor of ventral denticle belt phenotype of arm²

(Cavallo et al., 1998)

NOT Suppressor of

Statement

Reference

pan³, Scer\GAL4^30A is a non-suppressor of wing phenotype of Pka-C1^UAS.cKa, Scer\GAL4^30A

(Kiger et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The wing notch phenotype seen in Chi^e5.5/+ mutants is partially suppressed by the presence of pan³/+.

(van Tienen et al., 2017)

pan³ mutant embryos exhibit the same denticle lawn phenotype irrespective of the presence or absence of Scer\GAL4^arm.PS>dsh^{DIX.Scer\UAS.T:ctail-arr}.

(Metcalfe et al., 2010)

The pan³ mutant phenotype is not affected if the embryos are also maternally and zygotically homozygous for Apc2^ΔS.

(McCartney et al., 1999)

Heterozygotes show a partial and homozygotes a more complete suppression of the wg^l-17 embryonic cuticle defect.

(Cavallo et al., 1998)

Xenogenetic Interactions

Statement

Reference

pan³/+ significantly partially suppresses the decreased lifespan seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU or Scer\GAL4^Eaat1.PR.

(Dupont et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

4760

pan³/Dp(2;4)ey^D, Ablp^eyD: ey^D

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

TCF³

(Ravindranath and Cadigan, 2014)

dTCF³

(Metcalfe et al., 2010, Freeman and Bienz, 2001, McCartney et al., 1999, Cavallo et al., 1998, van de Wetering et al., 1997)

dTcf³

(van Tienen et al., 2017, Gallet et al., 1998)

pan³

(Dupont et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

Open Close