FlyBase Allele Report: Dmel\Vang[stbm-6]

General Information

Symbol

Dmel\Vang^stbm-6

Species

D. melanogaster

Name

FlyBase ID

FBal0062423

Feature type

allele

Associated gene

Dmel\Vang

Associated Insertion(s)

Carried in Construct

Also Known As

stbm⁶, Vang⁶, stbm^6cn, Vang^stbm6, stbm^null

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

loss of function allele

(Wolff and Rubin, 1998)

Mutagen

X ray

(Wolff and Rubin, 1998)

Progenitor genotype

Cytology

Description

2bp deletion at nucleotide 243, resulting in a frameshift at amino acid 81.

(Wolff and Rubin, 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:9,103,809..9,103,810 [+]

Comment:

Reported to be a 2bp deletion at nucleotide 243 creating a frameshift mutation at amino acid 81; position of mutation on reference sequence inferred by FlyBase curator based (using A of ATG of GB:AF044208 as position 1).

(Wolff and Rubin, 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neural tube defect

CEA

(Humphries et al., 2020)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates autosomal recessive intellectual developmental disorder

modeled by Nab2^ex3

(Corgiat et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity | adult stage, with Vang^arm.PU

(Strutt et al., 2016)

abnormal neuroanatomy | P-stage

(Han et al., 2020)

abnormal planar polarity

(Mirkovic et al., 2011, Rawls et al., 2007, Lawrence et al., 2004)

abnormal planar polarity (with Vang^A3)

(Strutt and Strutt, 2007)

abnormal planar polarity | cell non-autonomous | somatic clone

(Strutt and Strutt, 2007, Lawrence et al., 2004)

abnormal planar polarity | pupal stage

(Bellaiche et al., 2004)

abnormal planar polarity | recessive

(Pataki et al., 2010)

abnormal planar polarity | somatic clone

(Lawrence et al., 2004)

lethal - all die during embryonic stage | maternal effect

(Lee et al., 2003)

male fertile

(Steinhauer et al., 2019)

some die during embryonic stage | maternal effect

(Lee et al., 2003)

viable

(Lawrence et al., 2004, Wolff and Rubin, 1998)

visible

(Wolff and Rubin, 1997)

visible | recessive

(Pataki et al., 2010, Wolff and Rubin, 1998)

Phenotype Manifest In

border follicle cell

(Bastock and Strutt, 2007)

border follicle cell | cell non-autonomous

(Bastock and Strutt, 2007)

border follicle cell | somatic clone

(Bastock and Strutt, 2007)

cone cell

(Wolff and Rubin, 1998)

embryo | maternal effect

(Lee et al., 2003)

eye

(Wolff and Rubin, 1998)

macrochaeta & prothoracic segment

(Wolff and Rubin, 1998)

medulla | P-stage

(Han et al., 2020)

mesothoracic bristle

(Wolff and Rubin, 1998)

mesothoracic leg sensillum

(Wolff and Rubin, 1998)

metathoracic bristle

(Wolff and Rubin, 1998)

metathoracic leg sensillum

(Wolff and Rubin, 1998)

ommatidium

(Mirkovic et al., 2011, Rawls et al., 2007, Wolff and Rubin, 1998, Wolff and Rubin, 1997)

ommatidium (with Vang^A3)

(Strutt and Strutt, 2007)

ommatidium | adult stage (with Vang^A3)

(Cho et al., 2022)

photoreceptor cell R3

(Wolff and Rubin, 1998)

photoreceptor cell R4

(Wolff and Rubin, 1998)

polar follicle cell, with Scer\GAL4^slbo.2.6, Vang^RNAi.UAS

(Bastock and Strutt, 2007)

prothoracic leg sensillum

(Wolff and Rubin, 1998)

rhabdomere

(Wolff and Rubin, 1998)

secondary pigment cell

(Wolff and Rubin, 1998)

sperm individualization complex

(Steinhauer et al., 2019)

tarsal segment 2

(Wolff and Rubin, 1998)

tarsal segment 3

(Wolff and Rubin, 1998)

tarsal segment 4

(Wolff and Rubin, 1998)

tertiary pigment cell

(Wolff and Rubin, 1998)

trichome

(Wolff and Rubin, 1998)

trichome & adult abdomen

(Lawrence et al., 2004)

trichome & adult abdomen | somatic clone

(Lawrence et al., 2004)

trichome & adult abdomen | somatic clone | cell non-autonomous

(Lawrence et al., 2004)

trichome & adult head

(Wolff and Rubin, 1998)

trichome & adult thorax

(Wolff and Rubin, 1998)

trichome & pleural membrane

(Lawrence et al., 2004)

trichome & pleural membrane | somatic clone

(Lawrence et al., 2004)

trichome & pleural membrane | somatic clone | cell non-autonomous

(Lawrence et al., 2004)

waste bag

(Steinhauer et al., 2019)

wing

(Wolff and Rubin, 1998)

wing | pupal stage

(Pataki et al., 2010)

wing cell | P-stage

(Classen et al., 2005)

wing hair

(Wolff and Rubin, 1998)

wing hair, with Vang^arm.PU

(Strutt et al., 2016)

wing hair | cell non-autonomous | pupal stage | somatic clone

(Strutt and Strutt, 2007)

Detailed Description

Statement

Reference

Vang^stbm-6 testes have slightly (but significantly) fewer waste bags and normal individualization complexes (ICs) while they have a similar number of abnormal ICs when compared to controls.

(Steinhauer et al., 2019)

Vang^EGFP.C, Vang^stbm-6 individuals exhibit normal wings with normal trichome polarity.

Vang^arm.PU, Vang^stbm-6 individuals exhibit wing trichome orientation defects only in the proximal regions.

(Strutt et al., 2016)

Homozygous larvae show increased crossing of dendrites in the dendritic arbor of the ddaC class IV neurons compared to wild type.

(Matsubara et al., 2011)

The angle and direction of rotation of ommatidia is randomised in mutant eyes.

(Mirkovic et al., 2011)

The directional preferences of growing microtubules in mutant wing cells is not significantly different from that seen in wild type at 24 hours after puparium formation.

(Harumoto et al., 2010)

In wild-type wings, the ratio of non-hexagonally shaped cells relative to hexagonally shaped cells is around 11%, whereas in Vang^stbm-6 homozygous mutant wings this ratio increases to 30%.

Vang^stbm-6 mutant wings display strong hair orientation defects, but very few if any multiple hairs.

(Pataki et al., 2010)

Overall length of the tracheal dorsal trunk is normal in hemizygous stage 16 embryos.

(Chung et al., 2009)

Vang^stbm-6 mutant border cells are predominantly found at the lagging edge of border cell clusters compared to wild-type cells that show a strong preference to migrate at the leading edge of the cluster.

Border cell clusters from Vang^stbm-6 mutants show an average of 37 actin protrusions, reduced compared to the average of 94.8 in wild-type clusters.

In border cell clusters where both polar follicle cells are mutant for fz¹⁵ there is no preference for non-mutant border cells to take up the leading edge positions in the cluster, which is observed when polar cells are wild-type. In border cell clusters where only one polar follicle cell is mutant for fz¹⁵, this mutant cell displays no preference for position at the front or back of the cluster.

(Bastock and Strutt, 2007)

Homozygotes show defects in ommatidial polarity.

(Rawls et al., 2007)

Vang^stbm-6/Vang^A3 adults show defects in ommatidial patterning, with ommatidia pointing in random directions with randomised chirality.

Homozygous clones in the pupal wing (32 hours after puparium formation) cause neighbouring cells to point their trichomes away from the clone.

(Strutt and Strutt, 2007)

The hexagonal packing of intervein cells, which usually occurs between wing development stage P2B (when the first morphological signs of veins appear (FBrf0005070), and the middle of P2C (before hair formation (FBrf0005070)) is disrupted in Vang^stbm-6/Vang^stbm-6 flies.

(Classen et al., 2005)

In Vang^stbm-6 mutant pupae, the mitotic spindles of dividing sensory organ precursor cells in the developing notum are not aligned with the anterior-posterior axis, but instead are randomly oriented.

(Bellaiche et al., 2004)

Vang^stbm-6 flies are viable with a planar polarity phenotype in the tergites which resembles that seen in fz^- flies: they are disheveled, especially in the anterior parts of the anterior compartment, but have largely normal polarity elsewhere. Similarly, in the pleura, polarity is generally disordered, as in fz^-, except that there is a weak tendency for the hairs to be organized into zones of alternating polarity along the antero-posterior axis. The hairs in the middle of the anterior compartment tend to be reversed, with the remaining hairs being more normally polarised.

Within Vang^stbm-6 somatic clones in the adult abdomen the rows of hairs are jumbled and poorly oriented: some hairs point straight upwards, especially those in clones in anterior regions of the anterior compartment. Disruption of polarity extends a few cells anterior to these clones. This non-autonomous effect is variable, usually including patches with some hairs that are reversed. Reversal anterior to clones is more consistent and extensive for clones in the pleura, but is unaffected by position on the anteroposterior axis and can extend across the A-P compartment boundary.

(Lawrence et al., 2004)

Vang^stbm-6 homozygous embryos fail to hatch, exhibiting a phenotype similar to unfertilized eggs.

(Lee et al., 2003)

Mutants show no significant disruption of ovarian morphology.

(Cohen et al., 2002)

Homozygotes are viable, although many embryos die between 0-4 hours after egg laying. Homozygotes have rough eyes, due to misalignment of the normally parallel rows of ommatidia. The majority of ommatidia in the eye are correctly assembled, and the misaligned eye lattice is due to aberrant orientation of ommatidial units, which can be in several orientations: normal (46%), reversed dorsoventrally (35%), reversed anteroposteriorly (7%) or reversed both dorsoventrally and anteroposteriorly (7%). In addition, although most ommatidia rotate the normal 90^o, some undergo partial or no rotation (3%). Photoreceptors R3 and R4 are bilaterally symmetrical in 2% of ommatidia, abolishing the chirality of these ommatidia. These ommatidia show a rectangular rather than the normal trapezoidal arrangement of rhabdomeres. The pigment cell lattice is also disrupted, as a consequence of ommatidial misorientation. The eyes contain a normal complement of primary pigment cells, bristles and cone cells, although a few ommatidia are missing one cone cell. The number of secondary and tertiary pigment cells is often correct, except at the vertices of partially or unrotated ommatidia, where there is an excess of these cell types. Ommatidial assembly is normal in homozygous eye discs, but rotation of the ommatidia is delayed, and some ommatidia initiate rotation in the wrong direction. The polarity of many thoracic bristles is abnormal in homozygous adults, and the leg bristles are oriented perpendicular to the leg. Hair polarity is disrupted throughout the body, for example surrounding the eye and on the wings and thorax. Extra tarsal segments or partial duplications are frequently seen in tarsal segments 3 and 4, and occasionally in tarsal segment 2. The wings are held out.

(Wolff and Rubin, 1998)

In mutant eyes some ommatidia show normal polarity, many show inversions on the anterior-posterior and dorsal ventral axis so consequently the equator is abolished.

(Wolff and Rubin, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Vang^stbm-6 has abnormal neuroanatomy | P-stage phenotype, enhanceable by fz¹⁵/fz2^C1

(Han et al., 2020)

Vang^stbm-6 has abnormal planar polarity phenotype, enhanceable by bdg¹⁶⁴/bdg¹⁶⁴

(Rawls et al., 2007)

Scer\GAL4^hs.2sev, Vang^stbm-6/Vang[+], shg^{dCR3h.UAS.sgGFP} has abnormal cell polarity phenotype, enhanceable by dgo[+]/dgo³⁸⁰

(Mirkovic and Mlodzik, 2006)

Vang^stbm-6 has abnormal planar polarity | somatic clone phenotype, enhanceable by pwn^unspecified

(Lawrence et al., 2004)

Suppressed by

Statement

Reference

Vang^stbm-6 has abnormal planar polarity | somatic clone phenotype, suppressible by fz²¹

(Wu and Mlodzik, 2008)

NOT suppressed by

Statement

Reference

Vang^stbm-6 has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, non-suppressible by pk^pk-sple-13/pk^pk-sple-13

(Strutt and Strutt, 2007)

Vang^stbm-6 has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, non-suppressible by dgo³⁸⁰/dgo³⁸⁰

(Strutt and Strutt, 2007)

Vang^stbm-6 has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, non-suppressible by dsh³/dsh³

(Strutt and Strutt, 2007)

Enhancer of

Statement

Reference

Vang^stbm-6/Vang[+] is an enhancer of decreased size | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

Vang^stbm-6/Vang[+] is an enhancer of visible | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

Vang^stbm-6/Vang[+] is an enhancer of abnormal neuroanatomy phenotype of DAAM^Ex1

(Gombos et al., 2015)

Vang^stbm-6/Vang[+] is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

Vang^stbm-6/Vang[+] is an enhancer of visible phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

Vang^stbm-6 is an enhancer of abnormal planar polarity phenotype of nmo^P1

(Mirkovic et al., 2011)

Vang^stbm-6 is an enhancer of visible | recessive phenotype of Rab23⁵¹

(Pataki et al., 2010)

Vang^stbm-6 is an enhancer of abnormal planar polarity | recessive phenotype of Rab23⁵¹

(Pataki et al., 2010)

Vang^stbm-6/Vang[+] is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

Vang^stbm-6/Vang[+] is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, dgo[+]/dgo³⁸⁰, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

Vang^stbm-6 is an enhancer of abnormal cell polarity phenotype of pk^pk.sev

(Jenny et al., 2003)

Vang^stbm-6 is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Jenny et al., 2003)

NOT Enhancer of

Statement

Reference

Vang^stbm-6/Vang[+] is a non-enhancer of abnormal neuroanatomy | adult stage | dominant phenotype of tap^Gal4

(Yuan et al., 2016)

Vang^stbm-6/Vang[+] is a non-enhancer of abnormal planar polarity phenotype of fw^sev.Tag:HA

(Chin and Mlodzik, 2013)

Vang^stbm-6/Vang[+] is a non-enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Suppressor of

Statement

Reference

Vang^stbm-6/Vang[+] is a suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

Vang^stbm-6/Vang[+] is a suppressor of abnormal planar polarity phenotype of bdg^GMREP

(Rawls et al., 2007)

Vang^stbm-6/Vang^stbm-6 is a suppressor of abnormal planar polarity | somatic clone | cell non-autonomous phenotype of Scer\GAL4^αTub84B.PL, fz^UAS.cSa

(Lawrence et al., 2004)

Vang^stbm-6/Vang^stbm-6 is a suppressor of abnormal planar polarity | somatic clone | cell non-autonomous phenotype of fz¹⁵

(Lawrence et al., 2004)

NOT Suppressor of

Statement

Reference

Vang^stbm-6/Vang[+] is a non-suppressor of abnormal planar polarity phenotype of fw^sev.Tag:HA

(Chin and Mlodzik, 2013)

Vang^stbm-6/Vang[+] is a non-suppressor of abnormal planar polarity phenotype of Scer\GAL4^Bx-MS1096, kermit^UAS.cLa

(Lin and Katanaev, 2013)

Vang^stbm-6/Vang[+] is a non-suppressor of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Vang^stbm-6 is a non-suppressor of abnormal planar polarity | somatic clone phenotype of fz²¹

(Wu and Mlodzik, 2008)

Other

Statement

Reference

Vang^stbm-6, dgo³⁸⁰, pk^pk-sple-13 has abnormal cell polarity | adult stage phenotype

(Strutt et al., 2016)

Vang^stbm-6, dgo³⁸⁰, dsh³, pk^pk-sple-13 has abnormal cell polarity | adult stage phenotype

(Strutt et al., 2016)

Scer\GAL4^en-e16E, Vang^stbm-6/Vang[+], dgo³⁰⁸ has abnormal planar polarity phenotype

(Weber et al., 2012)

CG15283^GD13108, Scer\GAL4^en-e16E, Vang^stbm-6/Vang[+] has abnormal planar polarity phenotype

(Weber et al., 2012)

CG15283^GD13108, Scer\GAL4^en-e16E, Vang^stbm-6/Vang[+], dgo[+]/dgo²⁶⁹ has abnormal planar polarity phenotype

(Weber et al., 2012)

Vang^stbm-6, stan[+]/stan^E59 has abnormal neuroanatomy | third instar larval stage phenotype

(Matsubara et al., 2011)

Vang^stbm-6, fry¹/fry[+] has abnormal neuroanatomy | third instar larval stage phenotype

(Matsubara et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

Vang^stbm-6 has medulla | P-stage phenotype, enhanceable by fz¹⁵/fz2^C1

(Han et al., 2020)

Vang^stbm-6 has ommatidium phenotype, enhanceable by bdg¹⁶⁴/bdg¹⁶⁴

(Rawls et al., 2007)

Scer\GAL4^hs.2sev, Vang^stbm-6/Vang[+], shg^{dCR3h.UAS.sgGFP} has ommatidium phenotype, enhanceable by dgo[+]/dgo³⁸⁰

(Mirkovic and Mlodzik, 2006)

Vang^stbm-6 has trichome & adult abdomen phenotype, enhanceable by pwn^unspecified

(Lawrence et al., 2004)

Suppressed by

Statement

Reference

Vang^stbm-6 has wing hair | somatic clone phenotype, suppressible by fz²¹

(Wu and Mlodzik, 2008)

Vang^stbm-6 has trichome & adult abdomen | somatic clone | cell non-autonomous phenotype, suppressible by fz²¹/fz²¹

(Lawrence et al., 2004)

NOT suppressed by

Statement

Reference

Vang^stbm-6 has wing hair | somatic clone | cell non-autonomous | pupal stage phenotype, non-suppressible by dsh³/dsh³

(Strutt and Strutt, 2007)

Vang^stbm-6 has wing hair | somatic clone | cell non-autonomous | pupal stage phenotype, non-suppressible by pk^pk-sple-13/pk^pk-sple-13

(Strutt and Strutt, 2007)

Vang^stbm-6 has wing hair | somatic clone | cell non-autonomous | pupal stage phenotype, non-suppressible by dgo³⁸⁰/dgo³⁸⁰

(Strutt and Strutt, 2007)

Enhancer of

Statement

Reference

Vang^stbm-6/Vang[+] is an enhancer of eye phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

Vang^stbm-6/Vang[+] is an enhancer of adult mushroom body alpha-lobe phenotype of DAAM^Ex1

(Gombos et al., 2015)

Vang^stbm-6/Vang[+] is an enhancer of adult mushroom body beta-lobe phenotype of DAAM^Ex1

(Gombos et al., 2015)

Vang^stbm-6/Vang[+] is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

Vang^stbm-6/Vang[+] is an enhancer of wing hair phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

Vang^stbm-6 is an enhancer of ommatidium phenotype of nmo^P1

(Mirkovic et al., 2011)

Vang^stbm-6 is an enhancer of wing hair phenotype of Rab23⁵¹

(Pataki et al., 2010)

Vang^stbm-6/Vang[+] is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

Vang^stbm-6/Vang[+] is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, dgo[+]/dgo³⁸⁰, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

Vang^stbm-6/Vang[+] is an enhancer of wing cell | adult stage | heat sensitive phenotype of shi¹

(Classen et al., 2005)

Vang^stbm-6 is an enhancer of ommatidium phenotype of pk^pk.sev

(Jenny et al., 2003)

Vang^stbm-6 is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Jenny et al., 2003)

NOT Enhancer of

Statement

Reference

Vang^stbm-6/Vang[+] is a non-enhancer of adult mushroom body alpha-lobe | adult stage phenotype of tap^Gal4

(Yuan et al., 2016)

Vang^stbm-6/Vang[+] is a non-enhancer of ommatidium phenotype of fw^sev.Tag:HA

(Chin and Mlodzik, 2013)

Vang^stbm-6/Vang[+] is a non-enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Suppressor of

Statement

Reference

Vang^stbm-6/Vang[+] is a suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

Vang^stbm-6/Vang[+] is a suppressor of ommatidium phenotype of bdg^GMREP

(Rawls et al., 2007)

Vang^stbm-6/Vang^stbm-6 is a suppressor of trichome & adult abdomen | somatic clone | cell non-autonomous phenotype of Scer\GAL4^αTub84B.PL, fz^UAS.cSa

(Lawrence et al., 2004)

Vang^stbm-6/Vang^stbm-6 is a suppressor of trichome & abdomen | cell non-autonomous | somatic clone phenotype of fz¹⁵

(Lawrence et al., 2004)

NOT Suppressor of

Statement

Reference

Vang^stbm-6/Vang[+] is a non-suppressor of ommatidium phenotype of fw^sev.Tag:HA

(Chin and Mlodzik, 2013)

Vang^stbm-6/Vang[+] is a non-suppressor of wing hair | increased number phenotype of Scer\GAL4^Bx-MS1096, kermit^UAS.cLa

(Lin and Katanaev, 2013)

Vang^stbm-6/Vang[+] is a non-suppressor of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Vang^stbm-6 is a non-suppressor of wing hair | somatic clone phenotype of fz²¹

(Wu and Mlodzik, 2008)

Other

Statement

Reference

Vang^stbm-6, dgo³⁸⁰, pk^pk-sple-13 has wing hair phenotype

(Strutt et al., 2016)

Vang^stbm-6, dgo³⁸⁰, dsh³, pk^pk-sple-13 has wing hair phenotype

(Strutt et al., 2016)

Scer\GAL4^en-e16E, Vang^stbm-6/Vang[+], dgo³⁰⁸ has wing hair phenotype

(Weber et al., 2012)

CG15283^GD13108, Scer\GAL4^en-e16E, Vang^stbm-6/Vang[+] has wing hair phenotype

(Weber et al., 2012)

CG15283^GD13108, Scer\GAL4^en-e16E, Vang^stbm-6/Vang[+], dgo[+]/dgo²⁶⁹ has wing hair phenotype

(Weber et al., 2012)

Vang^stbm-6, stan[+]/stan^E59 has dendrite | third instar larval stage phenotype

(Matsubara et al., 2011)

Vang^stbm-6, stan[+]/stan^E59 has larval dorsal multidendritic neuron ddaC | third instar larval stage phenotype

(Matsubara et al., 2011)

Vang^stbm-6, fry¹/fry[+] has dendrite | third instar larval stage phenotype

(Matsubara et al., 2011)

Vang^stbm-6, fry¹/fry[+] has larval dorsal multidendritic neuron ddaC | third instar larval stage phenotype

(Matsubara et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Vang^stbm-6, dgo³⁸⁰, pk^pk-sple-13 and dsh³, Vang^stbm-6, dgo³⁸⁰, pk^pk-sple-13 triple and quadruple heterozygotes exhibit mild wing trichome orientation defects in proximal regions.

(Strutt et al., 2016)

Vang^stbm-6/+ does not significantly enhance frequency of mushroom body beta lobe axon overgrowth defects in tap^Gal4/+ brains.

(Yuan et al., 2016)

One copy of Vang^stbm-6 enhances the axonal projection defects seen in the αlobes of DAAM^Ex1 mutant mushroom bodies. The β lobe defects are also enhanced but not as strongly.

(Gombos et al., 2015)

Vang^stbm-6/+ has no effect on the planar cell polarity phenotype in the eye caused by expression of two copies of fw^{sev.T:Ivir\HA1}.

(Chin and Mlodzik, 2013)

Vang^stbm-6/+ does not affect the multiple wing hair phenotype caused by expression of kermit^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096.

(Lin and Katanaev, 2013)

Vang^stbm-6/+ significantly enhances both the eye and wing defects induced by the overexpression of dgo^Scer\UAS.cFa under the control of Scer\GAL4^hs.2sev.

(Weber et al., 2012)

stan^E59/Vang^stbm-6 double heterozygous larvae show increased crossing of dendrites in the dendritic arbor of the ddaC class IV neurons compared to wild type (neither single heterozygote shows this phenotype).

fry¹/Vang^stbm-6 double heterozygous larvae show increased crossing of dendrites in the dendritic arbor of the ddaC class IV neurons compared to wild type (neither single heterozygote shows this phenotype).

(Matsubara et al., 2011)

Vang^stbm-6/+ suppresses the ommatidial over-rotation phenotype which is caused by expression of nmo^Scer\UAS.cUa under the control of Scer\GAL4^hs.2sev.

(Mirkovic et al., 2011)

Many ommatidia do not rotate at all and remain oriented parallel to the equator in Vang^stbm-6 nmo^P1 double mutants.

(Mirkovic et al., 2011)

The double mutant combination Vang^stbm-6, Rab23⁵¹ displays a very high number of multiple wing hairs and strong hair orientation defects.

(Pataki et al., 2010)

Vang^stbm-6 clones in the pupal wing in a uniformly fz²¹ background show no difference in the time of prehair initiation between single and double mutant tissue.

fz²¹ clones in the pupal wing in a uniformly Vang^stbm-6 background show prehairs initiating sooner in Vang^stbm-6 mutant tissue than in Vang^stbm-6 ; fz²¹ double mutant tissue.

(Strutt and Warrington, 2008)

As is seen with fz²¹ clones alone, fz²¹ Vang^stbm-6 double mutant clones non-autonomously reorient the wing hairs of neighbouring wild type cells so that they point towards the clone.

(Wu and Mlodzik, 2008)

Homozygosity for bdg¹⁶⁴ enhances the ommatidial polarity defects caused by homozygosity for Vang^stbm-6.

The ommatidial polarity defects seen in bdg^GMREP homozygotes are dominantly suppressed by Vang^stbm-6.

(Rawls et al., 2007)

Vang^stbm-6/Vang^stbm-6 fz¹⁵/fz²¹ clones in the pupal wing (32 hours after puparium formation) have negligible effects on the polarity of trichomes in neighbouring cells. Trichome polarity is also relatively unperturbed within the double mutant clones.

stan^E59 Vang^stbm-6 double mutant clones in the pupal wing (23 hours after puparium formation) do not affect polarity of trichomes in surrounding wild-type tissue.

dsh³ Vang^stbm-6/Vang^stbm-6 clones in the pupal wing (32 hours after puparium formation) cause neighbouring cells to point their trichomes away from the clone, as occurs with Vang^stbm-6/Vang^stbm-6 single mutant clones in the pupal wing.

pk^pk-sple-13 Vang^stbm-6/Vang^stbm-6 clones in the pupal wing (32 hours after puparium formation) cause neighbouring cells to point their trichomes away from the clone, as occurs with Vang^stbm-6/Vang^stbm-6 single mutant clones in the pupal wing.

dgo³⁸⁰ Vang^stbm-6/Vang^stbm-6 clones in the pupal wing (32 hours after puparium formation) cause neighbouring cells to point their trichomes away from the clone, as occurs with Vang^stbm-6/Vang^stbm-6 single mutant clones in the pupal wing.

Clones expressing fz^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^Act5C.PI in a Vang^stbm-6 background do not affect the polarity of trichomes in the surrounding non-clonal tissue.

(Strutt and Strutt, 2007)

Both a dgo³⁸⁰/+ and a Vang^stbm-6/+ background enhances the ommatidial rotation phenotype of Scer\GAL4^hs.2sev>shg^{dCR3h.Scer\UAS.T:Avic\GFP-rs} eyes; a dgo³⁸⁰/+, Vang^stbm-6/+ double mutant background further enhances this phenotype.

(Mirkovic and Mlodzik, 2006)

The formation of holes in wings due to temperature shift of shi¹/shi¹ animals during pupal stages is moderately enhanced by Vang^stbm-6/+.

(Classen et al., 2005)

The loss of polarity seen in Vang^stbm-6 somatic clones in the adult abdomen is enhanced by pwn^unspecified. The loss of cell polarity seen adjacent to these clones is suppressed by fz²¹/fz²¹.

(Lawrence et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Vang^stbm-6/Vang^A3 is rescued by Vang^Act5C.EYFP

(Strutt and Strutt, 2007)

Vang^stbm-6 is rescued by Scer\GAL4^neur-P72/Vang^UAS.mGFP6

(Bellaiche et al., 2004)

Vang^stbm-6 is rescued by Scer\GAL4^neur-P72/Vang^{ΔPBM.UAS.mGFP6}

(Bellaiche et al., 2004)

Partially rescued by

Vang^stbm-6/Vang^A3 is partially rescued by Vang^UAS.cLa/Scer\GAL4^GMR.PY

(Cho et al., 2022)

Vang^stbm-6/Vang^A3 is partially rescued by Vang^sev.PS

(Strutt and Strutt, 2007)

Comments

Vang^{Act5C.T:Avic\GFP-EYFP} can rescue the wing planar polarity defects seen in Vang^stbm-6/Vang^A3 animals. Expression at 6 hours after puparium formation (APF) results in only minor polarity defects in the rescued wings. The rescue progressively worsens if expression is induced between 12 and 24 hours APF, with expression induced at 30 hours APF providing no rescue.

Vang^sev.PS partially rescues the ommatidial patterning defects of Vang^stbm-6/Vang^A3 adults. The ommatidial misrotation defect is largely rescued, but the dorsoventral inversion phenotype is not rescued.

(Strutt and Strutt, 2007)

Vang^{Scer\UAS.T:Avic\GFP-m6}; Scer\GAL4^neur-P72 rescues oriented cell division in the pupal notum of Vang^stbm-6 mutant animals.

(Bellaiche et al., 2004)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6918

Vang^stbm-6

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

Vang⁶

(Humphries et al., 2023, Payankaulam et al., 2022, Hing et al., 2020, Humphries et al., 2020, Steinhauer et al., 2019, Chin and Mlodzik, 2013, Weber et al., 2012, Pataki et al., 2010)

Vang^stbm-6

(Corgiat et al., 2022, Payankaulam et al., 2022, Yuan et al., 2016, Gombos et al., 2015, Lin and Katanaev, 2013, Weber et al., 2012, Wu and Mlodzik, 2008)

Vang^stbm6

(Matsubara et al., 2011)

Vang^stbm6c

(Gomes et al., 2009)

stbm-6

(Lee et al., 2003)

stbm^6CN

(Cohen et al., 2002)

stbm^6c

(Bellaiche et al., 2004)

stbm^6cn

(Rawls et al., 2007, Jenny et al., 2005, Das et al., 2004, Rawls and Wolff, 2003, Cohen et al., 2002, Wolff and Rubin, 1998)

stbm^null

(Thuveson et al., 2019, Jenny et al., 2003)

stbm^stbm-6

(Shimizu et al., 2011)

vang⁶

(Han et al., 2020)

vang^stbm-6

(Han et al., 2020)

vang^stbm6

(Song et al., 2023, Cho et al., 2022, Cho et al., 2020, Lee et al., 2020, Cho et al., 2015)

Name Synonyms

Secondary FlyBase IDs

FBal0062421

References (63)

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