FlyBase Allele Report: Dmel\fz[15]

General Information

Symbol

Dmel\fz¹⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0004931

Feature type

allele

Associated gene

Dmel\fz

Associated Insertion(s)

Carried in Construct

Also Known As

fz^H51, fz^HS1

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Tomlinson and Struhl, 1999, Jones et al., 1996)

loss of function allele

(Tomlinson et al., 1997)

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Polytene chromosomes normal.

Description

Amino acid replacement: W500term.

(Jones et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:14,367,034..14,367,034 [+]

Nucleotide change:

G14367034A

Reported nucleotide change:

T?A

Amino acid change:

W500term | fz-PA; W500term | fz-PC

Reported amino acid change:

W500term

Comment:

TGG to TGA nonsense mutation at amino acid 500.

(Jones et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | dominant

(Srahna et al., 2006)

abnormal neuroanatomy | P-stage (with fz²¹)

(Han et al., 2020)

abnormal neuroanatomy | P-stage | somatic clone

(Han et al., 2020)

abnormal planar polarity

(Linnemannstöns et al., 2014)

abnormal planar polarity, with Scer\GAL4^en-e16E, fz^UAS.cSa

(Lawrence et al., 2004)

abnormal planar polarity (with fz²⁵)

(Strutt and Strutt, 2002)

abnormal planar polarity (with fz³⁷)

(Strapps and Tomlinson, 2001)

abnormal planar polarity | cell non-autonomous | somatic clone

(Lawrence et al., 2004)

abnormal planar polarity | cell non-autonomous | somatic clone, with Scer\GAL4^Ubx.PdC, fz^UAS.cSa

(Lawrence et al., 2004)

abnormal planar polarity | cell non-autonomous | somatic clone (with fz²¹)

(Strutt and Strutt, 2007)

abnormal planar polarity | recessive | somatic clone

(Tomlinson and Struhl, 1999)

abnormal planar polarity | somatic clone

(Lawrence et al., 2004)

abnormal planar polarity | somatic clone, with Scer\GAL4^Ubx.PdC, fz^UAS.cSa

(Lawrence et al., 2004)

visible

(Strutt et al., 2012)

Phenotype Manifest In

axon & dorsal cluster neuron

(Srahna et al., 2006)

border follicle cell (with fz²³)

(Bastock and Strutt, 2007)

border follicle cell | cell non-autonomous | somatic clone

(Bastock and Strutt, 2007)

border follicle cell | somatic clone

(Bastock and Strutt, 2007)

eye (with fz³⁰)

(Kryuchkov et al., 2011)

leg

(Strutt et al., 2012)

leg joint | ectopic

(Strutt et al., 2012)

lens (with fz³⁰)

(Kryuchkov et al., 2011)

medulla | P-stage (with fz²¹)

(Han et al., 2020)

medulla | P-stage | somatic clone

(Han et al., 2020)

medulla intrinsic neuron Mi1 | P-stage | somatic clone

(Han et al., 2020)

ommatidium

(Tomlinson et al., 1997)

ommatidium (with fz³⁰)

(Kryuchkov et al., 2011)

ommatidium (with fz³⁷)

(Strapps and Tomlinson, 2001)

ommatidium | somatic clone

(Tomlinson and Struhl, 1999)

polar follicle cell | somatic clone

(Bastock and Strutt, 2007)

trichome & adult abdomen | somatic clone

(Lawrence et al., 2004)

trichome & adult abdomen | somatic clone | cell non-autonomous

(Lawrence et al., 2004)

trichome & pleural membrane, with Scer\GAL4^en-e16E, fz^UAS.cSa

(Lawrence et al., 2004)

trichome & pleural membrane | somatic clone

(Lawrence et al., 2004)

trichome & pleural membrane | somatic clone, with Scer\GAL4^Ubx.PdC, fz^UAS.cSa

(Lawrence et al., 2004)

trichome & pleural membrane | somatic clone | cell non-autonomous

(Lawrence et al., 2004)

trichome & pleural membrane | somatic clone | cell non-autonomous, with Scer\GAL4^Ubx.PdC, fz^UAS.cSa

(Lawrence et al., 2004)

wing

(Jones et al., 1996)

wing blade dorsal compartment | somatic clone (with fz²³)

(Doyle et al., 2008)

wing hair (with fz²⁵)

(Strutt and Strutt, 2002)

wing hair | cell non-autonomous | pupal stage | somatic clone (with fz²¹)

(Strutt and Strutt, 2007)

Detailed Description

Statement

Reference

Homozygous fz¹⁵ mutants are viable but exhibit planar polarity defects.

(Linnemannstöns et al., 2014)

Mutant adults have an average of 3.9 +/- 0.3 extra tarsal joints in the leg compared to wild type.

(Strutt et al., 2012)

fz¹⁵/fz³⁰ transheterozygous mutants exhibit 'rough' eyes. A Fourier transform of the mutant eye image reveals a set of concentric circles reflecting a non-ordered arrangement, instead of distinct reflexes up to the fourth order, as in wild-type. More intense regions arranged as apexes of hexagons, reflecting the existence of small regions of the eye surface with dense hexagonal ommatidial packing, can also be seen in the Fourier transform of these mutants. The diffraction pattern from the cornea of these transheterozygotes is noticeably smeared and only reflexes of the first order arranged in the hexagon apexes are observed. This confirms the limited periodicity of ommatidial arrangement and the existence of only small regions with dense hexagonal packing of ommatidia in the mutant flies.

While the borders of the wild-type ommatidia are tightly aligned to each other, irregular infiltrations of the lens material fill the gap between the lenses of fz¹⁵/fz³⁰ transheterozygous mutants. These infiltrations indicate that the packing of the mutant lenses is less compact, making them more loosely aligned to each other, explaining the 'rough' appearance and the lack of regularity.

The surface of the ommatidial lens at the nano-scale represents the array of nipples with a cross-section of 250nm and height of 30nm. fz¹⁵/fz³⁰ transheterozygous mutant nipples are shorter by 5nm but have the same broadness as those of wild-type flies.

(Kryuchkov et al., 2011)

fz²³/fz¹⁵ mutant clones in the wing non-autonomously disrupt wing membrane ridges.

(Doyle et al., 2008)

fz¹⁵ mutant border cells are predominantly found at the lagging edge of border cell clusters compared to wild-type cells that show a strong preference to migrate at the leading edge of the cluster.

In border cell clusters where both polar follicle cells are mutant for fz¹⁵ there is no preference for non-mutant border cells to take up the leading edge positions in the cluster. In border cell clusters where only one polar follicle cell is mutant for fz¹⁵, this mutant cell is observed towards the lagging end of the border cell cluster, whereas the polar cell retaining wild-type function is observed towards the leading edge of the cluster.

Border cell clusters from fz²¹/fz²³ mutants show an average of 38.4 actin protrusions, reduced compared to the average of 94.8 in wild-type clusters.

(Bastock and Strutt, 2007)

fz¹⁵/fz²¹ clones in the pupal wing (32 hours after puparium formation) cause neighbouring cells to point their trichomes towards the clone.

(Strutt and Strutt, 2007)

In fz¹⁵/+ adult brains, there is a significant reduction in the number of dorsal cluster neuron axons that cross toward the medulla compared to wild-type brains.

(Srahna et al., 2006)

Most larvae from fz¹⁵/fz²¹ mothers crossed with fz¹⁵/+ fathers have cuticles with normal morphology; only 2 of 30 exhibit fusions between segments. Another 2 mutants exhibit misplaced actin-based protrusions in denticle row 1.

(Walters et al., 2006)

fz¹⁵ somatic clones in the abdominal pleura have strong effects on planar cell polarity: the polarity of hair within the clone is randomised, except for the most anterior row of cells within the clone (normal polarity) and the most posterior row of cells within the clone (reversed polarity - hairs pointing into the clone). This reversal of hairs at the posterior of the clone extends behind the clone for about 2-4 rows of cells. This phenotype occurs wherever the clones are made, dorsally or ventrally, regardless of compartment, or of the presence of compartment boundaries.

(Lawrence et al., 2004)

fz¹⁵/fz²¹ ovaries show only very minor abnormalities.

(Cohen et al., 2002)

The wings of fz¹⁵/fz²⁵ animals have a trichome (wing hair) swirling pattern that is distinct from that due to ds^33k/ds^UAO71. Wing hairs in these wings form away from cell edges.

(Strutt and Strutt, 2002)

Only 47.1 +/- 8.9 % of ommatidia in fz³⁷/fz¹⁵ flies have the correct chiral shape.

(Strapps and Tomlinson, 2001)

Mosaic ommatidia at the boundaries of homozygous clones can show incorrect chirality. In incorrect chiral ommatidia where the mosaic boundary separates the R3/R4 pair, the R4 cell is invariably mutant and the R3 cell is wild type. In these cases the presumptive R3 cell has developed as an R4 cell. The R3/R4 pair can also either both be mutant or both be wild-type in mosaic ommatidia with incorrect chirality. Chirally incorrect ommatidia that have wild-type R3 and R4 cells can occur at any position along the border of the clone, but are predominantly found at the polar side of the clone. Mosaic ommatidia at the boundaries of homozygous clones can show correct chirality. In those ommatidia with mosaicism between R3/R4, the R3 cell is almost always wild type and the R4 cell is almost always mutant. Mosaic ommatidia at the boundaries of homozygous clones are occasionally symmetrical, and in these cases both members of the R3/R4 pair are generally mutant. Expression of fz^hs.sev in a fz¹⁵ background in either the presumptive R3 or R4 cell in mosaic ommatidia causes the cell expressing fz^hs.sev to become an R3 cell and the other to become an R4 cell.

(Tomlinson and Struhl, 1999)

Ommatidial orientations are disturbed, chiral shape is choosen randomly.

(Tomlinson et al., 1997)

Non-autonomous phenotype in wing clones.

(Jones et al., 1996)

strong thoracic bristle phenotype strong wing-hair disorientation

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Wnt10⁹¹, Wnt4⁰⁹, fz¹⁵ has abnormal neuroanatomy | P-stage phenotype, enhanceable by fz2^C1

(Han et al., 2020)

fz¹⁵ has abnormal neuroanatomy phenotype, enhanceable by Wnt5⁴⁰⁰/Wnt5[+]

(Srahna et al., 2006)

Suppressed by

Statement

Reference

fz¹⁵ has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, suppressible by Vang^stbm-6/Vang^stbm-6

(Lawrence et al., 2004)

fz¹⁵ has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, suppressible by stan³/stan³

(Lawrence et al., 2004)

fz¹⁵ has abnormal planar polarity | somatic clone phenotype, suppressible by stan³/stan³

(Lawrence et al., 2004)

fz³⁷/fz¹⁵ has abnormal planar polarity phenotype, suppressible by fz::fz2^{1-1-2.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has abnormal planar polarity phenotype, suppressible by fz::fz2^{1-2-1.hs.2sev}

(Strapps and Tomlinson, 2001)

NOT suppressed by

Statement

Reference

fz¹⁵ has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, non-suppressible by pk^pk-sple-13/pk^pk-sple-13

(Lawrence et al., 2004)

fz³⁷/fz¹⁵ has abnormal planar polarity phenotype, non-suppressible by fz::fz2^{1-2-2.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has abnormal planar polarity phenotype, non-suppressible by fz::fz2^{2-1-1.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has abnormal planar polarity phenotype, non-suppressible by fz::fz2^{2-2-1.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has abnormal planar polarity phenotype, non-suppressible by fz2^{2-2-2.hs.2sev}

(Strapps and Tomlinson, 2001)

fz2^C1, fz¹⁵ has lethal phenotype, non-suppressible by wg^UAS.Tag:HA/Scer\GAL4^h-1J3

(Chen and Struhl, 1999)

Enhancer of

Statement

Reference

fz¹⁵ is an enhancer of abnormal neuroanatomy | P-stage phenotype of Wnt10⁹¹, Wnt4⁰⁹, fz2^C1

(Han et al., 2020)

fz¹⁵/fz2^C1 is an enhancer of abnormal neuroanatomy | P-stage phenotype of Vang^stbm-6

(Han et al., 2020)

fz¹⁵/fz¹⁵ is an enhancer of abnormal neuroanatomy | P-stage | somatic clone phenotype of fz2^C1

(Han et al., 2020)

fz²¹/fz¹⁵ is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^Bx-MS1096, kermit^UAS.cLa

(Lin and Katanaev, 2013)

fz[+]/fz¹⁵ is an enhancer of abnormal neuroanatomy phenotype of Wnt5⁴⁰⁰

(Srahna et al., 2006)

fz¹⁵ is an enhancer of lethal | recessive phenotype of fz2^C1

(Chen and Struhl, 1999)

fz¹⁵ is an enhancer of abnormal planar polarity | somatic clone phenotype of fz2^C1

(Chen and Struhl, 1999)

NOT Enhancer of

Statement

Reference

fz¹⁵ is a non-enhancer of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

NOT Suppressor of

Statement

Reference

fz¹⁵ is a non-suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

fz2^C2/fz2^C1, fz¹⁵ has abnormal neuroanatomy | P-stage phenotype

(Han et al., 2020)

Wnt10⁹¹, Wnt4⁰⁹, fz¹⁵ has abnormal neuroanatomy | P-stage phenotype

(Han et al., 2020)

fz2^C1, fz²¹/fz¹⁵ has abnormal neuroanatomy | P-stage phenotype

(Han et al., 2020)

Df(2R)D72, fz¹⁵ has lethal phenotype

(Linnemannstöns et al., 2014)

Df(2R)D72, fz¹⁵/fz¹⁹ has lethal phenotype

(Linnemannstöns et al., 2014)

fz2^C1, fz¹⁵ has visible | somatic clone phenotype

(Strutt et al., 2012)

fz2^C1, fz¹⁵ has decreased cell number | pupal stage phenotype

(Cordero and Cagan, 2010)

fz2^C1, fz¹⁵ has decreased cell number | somatic clone | third instar larval stage phenotype

(Cordero and Cagan, 2010)

Scer\GAL4^αTub84B.PL, fz2^C1, fz¹⁵, vg^UAS.cKa has increased cell death phenotype

(Baena-Lopez and Garcia-Bellido, 2006)

fz2^C1, fz¹⁵ has abnormal neuroanatomy | somatic clone phenotype

(Srahna et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

Wnt10⁹¹, Wnt4⁰⁹, fz¹⁵ has medulla | P-stage phenotype, enhanceable by fz2^C1

(Han et al., 2020)

fz¹⁵ has axon & dorsal cluster neuron phenotype, enhanceable by Wnt5⁴⁰⁰/Wnt5[+]

(Srahna et al., 2006)

Suppressed by

Statement

Reference

fz¹⁵ has trichome & abdomen | cell non-autonomous | somatic clone phenotype, suppressible by Vang^stbm-6/Vang^stbm-6

(Lawrence et al., 2004)

fz¹⁵ has trichome & abdomen | cell non-autonomous | somatic clone phenotype, suppressible by stan³/stan³

(Lawrence et al., 2004)

fz¹⁵ has trichome & abdomen | somatic clone phenotype, suppressible by stan³/stan³

(Lawrence et al., 2004)

fz³⁷/fz¹⁵ has photoreceptor cell R4 | ectopic | somatic clone phenotype, suppressible by ft⁸

(Yang et al., 2002)

fz³⁷/fz¹⁵ has photoreceptor cell R3 | somatic clone phenotype, suppressible by ft⁸

(Yang et al., 2002)

fz³⁷/fz¹⁵ has ommatidium phenotype, suppressible by fz::fz2^{1-1-2.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has ommatidium phenotype, suppressible by fz::fz2^{1-2-1.hs.2sev}

(Strapps and Tomlinson, 2001)

fz2^C1, fz¹⁵ has embryo phenotype, suppressible | partially by arm^{ΔN.UAS.Tag:HA,Tag:Myr(Unk)}/Scer\GAL4^h-1J3

(Chen and Struhl, 1999)

fz2^C1, fz¹⁵ has embryonic epidermis phenotype, suppressible | partially by arm^{ΔN.UAS.Tag:HA,Tag:Myr(Unk)}/Scer\GAL4^h-1J3

(Chen and Struhl, 1999)

fz2^C1, fz¹⁵ has ventral denticle belt phenotype, suppressible | partially by arm^{ΔN.UAS.Tag:HA,Tag:Myr(Unk)}/Scer\GAL4^h-1J3

(Chen and Struhl, 1999)

NOT suppressed by

Statement

Reference

fz¹⁵ has trichome & abdomen | cell non-autonomous | somatic clone phenotype, non-suppressible by pk^pk-sple-13/pk^pk-sple-13

(Lawrence et al., 2004)

fz³⁷/fz¹⁵ has ommatidium phenotype, non-suppressible by fz2^{2-2-2.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has ommatidium phenotype, non-suppressible by fz::fz2^{1-2-2.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has ommatidium phenotype, non-suppressible by fz::fz2^{2-1-1.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has ommatidium phenotype, non-suppressible by fz::fz2^{2-2-1.hs.2sev}

(Strapps and Tomlinson, 2001)

fz2^C1, fz¹⁵ has phenotype, non-suppressible by wg^UAS.Tag:HA/Scer\GAL4^h-1J3

(Chen and Struhl, 1999)

Enhancer of

Statement

Reference

fz¹⁵ is an enhancer of medulla | P-stage phenotype of Wnt10⁹¹, Wnt4⁰⁹, fz2^C1

(Han et al., 2020)

fz¹⁵/fz2^C1 is an enhancer of medulla | P-stage phenotype of Vang^stbm-6

(Han et al., 2020)

fz¹⁵/fz¹⁵ is an enhancer of medulla | P-stage | somatic clone phenotype of fz2^C1

(Han et al., 2020)

fz¹⁵/fz¹⁵ is an enhancer of medulla intrinsic neuron Mi1 | P-stage | somatic clone phenotype of fz2^C1

(Han et al., 2020)

fz²¹/fz¹⁵ is an enhancer of wing hair phenotype of Scer\GAL4^Bx-MS1096, kermit^UAS.cLa

(Lin and Katanaev, 2013)

fz²¹/fz¹⁵ is an enhancer of wing hair | increased number phenotype of Scer\GAL4^Bx-MS1096, kermit^UAS.cLa

(Lin and Katanaev, 2013)

fz[+]/fz¹⁵ is an enhancer of axon & dorsal cluster neuron phenotype of Wnt5⁴⁰⁰

(Srahna et al., 2006)

fz¹⁵ is an enhancer of dorsal vessel wall cell phenotype of fz2^C1

(Chen and Struhl, 1999)

fz¹⁵ is an enhancer of wing disc phenotype of fz2^C1

(Chen and Struhl, 1999)

fz¹⁵ is an enhancer of scutum phenotype of fz2^C1

(Chen and Struhl, 1999)

fz¹⁵ is an enhancer of macrochaeta phenotype of fz2^C1

(Chen and Struhl, 1999)

fz¹⁵ is an enhancer of wing margin bristle | cell non-autonomous | somatic clone phenotype of fz2^C1

(Chen and Struhl, 1999)

fz¹⁵ is an enhancer of wing | cell non-autonomous | somatic clone phenotype of fz2^C1

(Chen and Struhl, 1999)

fz¹⁵ is an enhancer of wing margin bristle | ectopic phenotype of fz2^C1

(Chen and Struhl, 1999)

fz¹⁵ is an enhancer of embryo phenotype of fz2^C1

(Chen and Struhl, 1999)

fz¹⁵ is an enhancer of embryonic epidermis phenotype of fz2^C1

(Chen and Struhl, 1999)

fz¹⁵ is an enhancer of ventral denticle belt phenotype of fz2^C1

(Chen and Struhl, 1999)

fz¹⁵ is an enhancer of embryonic midgut constriction phenotype of fz2^C1

(Chen and Struhl, 1999)

fz¹⁵ is an enhancer of neuroblast NB4-2 phenotype of fz2^C1

(Chen and Struhl, 1999)

NOT Enhancer of

Statement

Reference

fz¹⁵ is a non-enhancer of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

fz¹⁵/fz2^C1 is a non-enhancer of interneuron phenotype of Scer\GAL4^eg-Mz360, drl^UAS.cCa

(Yoshikawa et al., 2003)

NOT Suppressor of

Statement

Reference

fz¹⁵ is a non-suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

fz¹⁵/fz2^C1 is a non-suppressor of interneuron phenotype of Scer\GAL4^eg-Mz360, drl^UAS.cCa

(Yoshikawa et al., 2003)

Other

Statement

Reference

fz2^C2/fz2^C1, fz¹⁵ has medulla | P-stage phenotype

(Han et al., 2020)

Wnt10⁹¹, Wnt4⁰⁹, fz¹⁵ has medulla | P-stage phenotype

(Han et al., 2020)

fz2^C1, fz²¹/fz¹⁵ has medulla | P-stage phenotype

(Han et al., 2020)

fz2^C1, fz¹⁵ has wing margin bristle | somatic clone phenotype

(Strutt et al., 2012)

fz2^C1, fz¹⁵ has wing margin | somatic clone phenotype

(Strutt et al., 2012)

fz2^C1, fz¹⁵ has cone cell | somatic clone | third instar larval stage phenotype

(Cordero and Cagan, 2010)

fz2^C1, fz¹⁵ has cone cell | somatic clone | pupal stage phenotype

(Cordero and Cagan, 2010)

Scer\GAL4^αTub84B.PL, fz2^C1, fz¹⁵, vg^UAS.cKa has wing disc phenotype

(Baena-Lopez and Garcia-Bellido, 2006)

fz2^C1, fz¹⁵ has axon & dorsal cluster neuron | somatic clone phenotype

(Srahna et al., 2006)

fz2^C1, fz¹⁵ has ommatidium | ectopic | somatic clone phenotype

(Baonza and Freeman, 2002)

fz2^C1, fz¹⁵ has tracheal dorsal trunk primordium | germline clone phenotype

(Llimargas and Lawrence, 2001)

fz2^C1, fz¹⁵ has larval tracheal system | germline clone phenotype

(Llimargas, 2000)

fz2^C1, fz¹⁵ has embryonic/larval tracheal dorsal trunk | germline clone phenotype

(Llimargas, 2000)

Additional Comments

Genetic Interactions

Statement

Reference

fz¹⁵/fz²¹ enhances the wing defects caused by expressing kermit^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096, with a significant increase in the number of wing cells with multiple hairs.

(Lin and Katanaev, 2013)

fz¹⁵ fz2^C1 double homozygous clones in the wing result in notching of the wing margin and loss of margin bristles in the mutant tissue.

(Strutt et al., 2012)

fz¹⁵ fz2^C1 double mutant clones exhibit cone cell loss 42 hours after pupal formation.

fz¹⁵ fz2^C1 double mutant clones exhibit reduced numbers of cone cells in third instar larval eye discs compared to controls.

(Cordero and Cagan, 2010)

Vang^stbm-6/Vang^stbm-6 fz¹⁵/fz²¹ clones in the pupal wing (32 hours after puparium formation) have negligible effects on the polarity of trichomes in neighbouring cells. Trichome polarity is also relatively unperturbed within the double mutant clones.

Clones expressing Vang^Scer\UAS.cBa under the control of Scer\GAL4^Act5C.PI in a fz¹⁵/Df(3L)fz-D21 background do not affect the polarity of trichomes in the surrounding non-clonal tissue.

(Strutt and Strutt, 2007)

Cell clones expressing vg^Scer\UAS.cKa under the control of Scer\GAL4^αTub84B.PL that are also mutant for fz¹⁵ and fz2^C1 (generated using the MARCM technique) are present in the wing disc 48 hours after heat-shock, with increased clone size further away from the dorsal-ventral boundary. However, at 72 hours after heat shock these mutant clones disappear as a result of cell death. Nonautonomous effects on growth and patterning are also seen in these mutant wing discs.

(Baena-Lopez and Garcia-Bellido, 2006)

fz¹⁵, fz2^C1 double mutant clones in the wing pouch fail to grow and survive. However, when induced late during larval development, these mutant clones display modest survival. fz¹⁵, fz2^C1 double mutant clones induced 24 hours before dissection survive but appear undergrown compared to their wild-type twins.

fz¹⁵, fz2^C1 double mutant clones induced in ft⁸ mutant discs during early larval stages fail to survive.

(Jaiswal et al., 2006)

No axons from fz¹⁵, fz2^C1 dorsal cluster neuron clones reach the medulla, while 37% of all axons from wild-type neurons reach the medulla.

Wnt5⁴⁰⁰/+; fz¹⁵/+ brains show a synergistic reduction in the number of dorsal cluster neuron axons that reach the medulla.

(Srahna et al., 2006)

Hairs around fz¹⁵ somatic clones in the abdomens of pk^pk-sple-13 homozygous flies point inwards, towards the clones, irrespective of whether they are anterior or posterior to the clone or located in regions of normal or reversed polarity.

The non-autonomous effect of fz¹⁵ somatic clones on planar polarity in the abdomen is suppressed by Vang^stbm-6/Vang^stbm-6.

A stan³/stan³ background blocks planar repolarisation both inside and outside fz¹⁵ homozygous clones in the adult abdomen.

(Lawrence et al., 2004)

Germband extension occurs normally in around 80% of fz¹⁵ fz2^C1 homozygous embryos from mothers carrying fz¹⁵ fz2^C1 germ line clones.

(Zallen and Wieschaus, 2004)

fz¹⁵ fz2^C1/fz¹⁵ fz2^C1 embryos produce cuticles with a lawn of denticles. Naked cuticle is restored in these embryos, by expression of arr::fz2^{arr.intra.Scer\UAS.T:Hsap\MYC} with Scer\GAL4^en-e16E.

(Tolwinski et al., 2003)

The addition of fz¹⁵ and fz2^C1 has no effect on the interneuron phenotype seen in drl^Scer\UAS.cCa, Scer\GAL4^eg-Mz360 animals.

(Yoshikawa et al., 2003)

fz2^C1 fz¹⁵ double mutant clones occasionally cause the differentiation of ectopic ommatidia on the dorsal adult head and these clones show overgrowth.

(Baonza and Freeman, 2002)

When ft⁸ homozygous mutant clones are made in the R3/R4 precursors of fz³⁷/fz¹⁵ mutant flies, The mutant photoreceptor precursor eventually becomes an R3 photoreceptor 61% of the time (50% in wild-type).

(Yang et al., 2002)

Embryos derived from fz¹⁵ fz2^C1 double mutant female germline clones lack all the dorsal trunk of the tracheal system (apart from minute vestiges of material found in the posterior part).

(Llimargas and Lawrence, 2001)

fz2^{2-2-2.hs.2sev} does not rescue the tissue polarity defect seen in fz³⁷/fz¹⁵ eyes. fz::fz2^{2-2-1.hs.2sev} does not rescue the tissue polarity defect seen in fz³⁷/fz¹⁵ eyes. fz::fz2^{2-1-1.hs.2sev} does not rescue the tissue polarity defect seen in fz³⁷/fz¹⁵ eyes. fz::fz2^{1-2-2.hs.2sev} does not rescue the tissue polarity defect seen in fz³⁷/fz¹⁵ eyes. fz::fz2^{1-1-2.hs.2sev} significantly rescues the tissue polarity defect seen in fz³⁷/fz¹⁵ eyes, such that 93.3 +/- 5.0 % of ommatidia have the correct chiral shape. fz::fz2^{1-2-1.hs.2sev} significantly rescues the tissue polarity defect seen in fz³⁷/fz¹⁵ eyes, such that 76.5 +/- 6.4 % of ommatidia have the correct chiral shape.

(Strapps and Tomlinson, 2001)

Embryos derived from fz¹⁵ fz2^C1 female germline clones show defects in tracheal invagination, branch fusion and dorsal trunk formation.

(Llimargas, 2000)

In mutant wing clones in combination with fz2^C1, the wing margin is defective. Neighboring wild type cells show ectopic wing margin bristles. wg signal transduction is lost: the mutant phenotype of the fz¹⁵, fz2^C1 clones resembles that of dsh⁷⁵. Embryos mutant zygotically and maternally for fz¹⁵ and fz2^C1 cannot transduce wg signalling. They show the wg shortened embryo/"lawn of denticles" phenotype, en expression is lost, midgut constructions fail to form, lab is not-up-regulated, the neuroblasts that generate the RP2 neurons are absent, wg-dependent eve-expressing cardiac myoblasts are lost. In combination with arm^{Δ.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^h-1J3 the naked sections of the embryonic cuticle are partially restored. In combination with wg^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^h-1J3 the naked sections of the embryonic cuticle are not restored. Embryos doubly mutant for fz¹⁵ and fz2^C1 from heterozygous parents die at the embryo/larval boundary. Double mutant clones in the wing disc are at a growth disadvantage and do not survive in the wing pouch region. Double mutant clones in the mesonotum can fill the entire mesonotum with the bristles showing a frizzled polarity phenotype. Clones of wg^- cells that fill the notum have a different phenotype in that fewer dorsocentral bristles form. Embryos and larvae lacking maternal fz and fz2 but having had fz or fz2 provided paternally are apparently normal.

(Chen and Struhl, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

fz¹⁵/fz²⁵ is rescued by fz^Act5C.EYFP

(Strutt and Strutt, 2002)

fz¹⁵/fz¹⁹ is rescued by fz^Act5C.EYFP

(Strutt and Strutt, 2002)

fz³⁷/fz¹⁵ is rescued by fz^{1-1-1.hs.2sev}

(Strapps and Tomlinson, 2001)

Partially rescued by

Df(3L)fz-GF3b/fz¹⁵ is partially rescued by fz^sevE3.sevP

(Strutt and Strutt, 2002)

fz¹⁵ is partially rescued by fz^sev.PT

(Tomlinson and Struhl, 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Adler.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

fz₁^H51

(Baena-Lopez and Garcia-Bellido, 2006)

fz^-

(Casal et al., 2006)

fz¹⁵

(Ayukawa et al., 2022, Bastock and Strutt, 2007, Strutt and Strutt, 2007, Casal et al., 2006, Lawrence et al., 2004)

fz^HB51

(Doyle et al., 2008)

fz^HS1

(Yasunaga et al., 2015, Casares and Mann, 2000)

fz^h51

(Cordero and Cagan, 2010, Srahna et al., 2006, Tomlinson et al., 1997)

fz[H51]

(Lin and Katanaev, 2013)

Name Synonyms

Secondary FlyBase IDs

References (49)

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