FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term neuroblast NB4-2 ID (Ontology) FBbt:00001389 (Fly Anatomy)
Definition Neuroblast that delaminates at S2 in the intermediate column and, in thoracic and abdominal segments, produces the RP2 motorneuron, which innervates muscles 2, 9 and 11, and the cousin of RP2 motorneuron (CoR), which innervates muscles 26, 27 and 29 (Schmid et al., 1999; Birkholz et al., 2013). It also generates around 19 interneurons (Schmid et al., 1999). In the embryo, one of these cells can be found in each hemisegment from S1-A9 (Birkholz et al., 2013; Urbach et al., 2016). In the larva, it resumes proliferation in all thoracic segments (Lacin and Truman, 2016). The neurons that develop from this neuroblast after larval hatching form postembryonic lineage 13 (Lacin and Truman, 2016).[ FlyBase:FBrf0112030 FlyBase:FBrf0221210 FlyBase:FBrf0228122 FlyBase:FBrf0231327 FlyBase:FBrf0232096 ]
Also Known As"lineage 13 neuroblast" ; "lineage NB4-2 neuroblast" ; "NB 13" (for all, see Synonyms field below)
CommentBirkholz et al. (2015) suggest that NB4-2 generates postembryonic lineage 7 and NB3-3 generates postembryonic lineage 13, but Lacin and Truman (2016) provide lineage tracing and marker data showing that NB4-2 generates lineage 13.
Links to External Ontologies
VFB:FBbt_00001389
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Data ClassFieldDirect annotations
Alleles (FBal)PHENOTYPE_MANIFEST_IN
Insertions (FBti)EXPRESSION_STAGE_TISSUE_POSITION
Insertions (FBti)PHENOTYPE_MANIFEST_IN
Constructs (FBtp)PHENOTYPE_MANIFEST_IN
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 Alleles Split System Combinations Genes Insertions Constructs
 neuroblast NB4-2 (all annotations which use CV term, excluding "NOT" statements)
     neuroblast NB4-2 | ectopic
      --       --       --
     neuroblast NB4-2 | somatic clone
      --       --
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central nervous system
 |__segmentally-repeated neuroblast__
neuroblast                           |
 |__stage 2 neuroblast_______________|
 |__segmentally-repeated neuroblast__|
ectodermal derivative                |
 |__segmentally-repeated neuroblast__|
                                     neuroblast NB4-2  53 rec.
                                      |__abdominal neuroblast NB4-2
                                      |__labial neuroblast NB4-2
                                      |__mandibular neuroblast NB4-2
                                      |__maxillary neuroblast NB4-2
                                      |__thoracic neuroblast NB4-2
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Is a stage 2 neuroblast
segmentally-repeated neuroblast
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VFB:FBbt_00001389