Open Close
Reference
Citation
Yoshikawa, S., McKinnon, R.D., Koel, M., Thomas, J.B. (2003). Wnt-mediated axon guidance via the Drosophila Derailed receptor.  Nature 422(6932): 583--588.
FlyBase ID
FBrf0157164
Publication Type
Research paper
Abstract

In nervous systems with bilateral symmetry, many neurons project axons across the midline to the opposite side. In each segment of the Drosophila embryonic nervous system, axons that display this projection pattern choose one of two distinct tracts: the anterior or posterior commissure. Commissure choice is controlled by Derailed, an atypical receptor tyrosine kinase expressed on axons projecting in the anterior commissure. Here we show that Derailed keeps these axons out of the posterior commissure by acting as a receptor for Wnt5, a member of the Wnt family of secreted signalling molecules. Our results reveal an unexpected role in axon guidance for a Wnt family member, and show that the Derailed receptor is an essential component of Wnt signalling in these guidance events.

PubMed ID
PubMed Central ID
Related Publication(s)
Review

Developmental biology: How neurons avoid derailment.
Garrity, 2003, Nature 422(6932): 570--571 [FBrf0157163]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference