FB2025_01 , released February 20, 2025
Allele: Dmel\Wnt5D7
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General Information
Symbol
Dmel\Wnt5D7
Species
D. melanogaster
Name
FlyBase ID
FBal0144486
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Imprecise excision of the P{GT1} insertion has created a 1,251 bp deletion that removes the first 261 amino acids of the Wnt5 coding region.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
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Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
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Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Wnt5D7 mutant adult brains often lack the commissure between the antennal lobes, that resemble inverted triangles, in contrast to being globular as in wild-type. In Wnt5D7 mutants, many of the glomeruli are located in the periphery of the antennal lobe are rotated in a clockwise manner in the right antennal lobe.

The tips of the salivary glands curve ventromedially towards the central nervous system in approximately 40% of Wnt5D7 embryos, instead of lying parallel to the midline as in wild-type embryos.

Mutant adults are uncoordinated. Mutant embryos have disorganised commissures. In many segments commissures appear irregular, and there are often abnormal axonal projections between the anterior and posterior commissures (AC and PC). In these cases it is the AC whose projections are defective. 80% of segments display abnormal projections of AC axons into the PC.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
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Reference
Phenotype Manifest In
Enhanced by
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Enhancer of
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Suppressor of
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Additional Comments
Genetic Interactions
Statement
Reference

The salivary glands of Wnt5D7 ; drlR343 double homozygous embryos show the same phenotype with similar penetrance as that seen in either of the single mutants alone.

Wnt5D7 ; drlR343 double heterozygotes show salivary gland guidance defects; the salivary glands curve ventromedially towards the central nervous system, instead of lying parallel to the midline as in wild-type embryos.

Wnt5D7 ; Wnt4EMS23 double mutants have a higher penetrance of salivary gland curving than is seen in either of the single mutants alone.

Xenogenetic Interactions
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Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)