Wnt5D7 mutant adult brains often lack the commissure between the antennal lobes, that resemble inverted triangles, in contrast to being globular as in wild-type. In Wnt5D7 mutants, many of the glomeruli are located in the periphery of the antennal lobe are rotated in a clockwise manner in the right antennal lobe.
The tips of the salivary glands curve ventromedially towards the central nervous system in approximately 40% of Wnt5D7 embryos, instead of lying parallel to the midline as in wild-type embryos.
Mutant adults are uncoordinated. Mutant embryos have disorganised commissures. In many segments commissures appear irregular, and there are often abnormal axonal projections between the anterior and posterior commissures (AC and PC). In these cases it is the AC whose projections are defective. 80% of segments display abnormal projections of AC axons into the PC.
Wnt5D7 is a suppressor of abnormal neurophysiology phenotype of Scer\GAL4eg-Mz360, drlUAS.cCa
Wnt5D7 has presumptive embryonic salivary gland phenotype, enhanceable by Wnt4EMS23
Wnt5D7 is an enhancer of presumptive embryonic salivary gland phenotype of Wnt4EMS23
Wnt5D7 is a suppressor of interneuron phenotype of Scer\GAL4eg-Mz360, drlUAS.cCa
The salivary glands of Wnt5D7 ; drlR343 double homozygous embryos show the same phenotype with similar penetrance as that seen in either of the single mutants alone.
Wnt5D7 ; drlR343 double heterozygotes show salivary gland guidance defects; the salivary glands curve ventromedially towards the central nervous system, instead of lying parallel to the midline as in wild-type embryos.
Wnt5D7 ; Wnt4EMS23 double mutants have a higher penetrance of salivary gland curving than is seen in either of the single mutants alone.