FlyBase Allele Report: Dmel\Wnt5[D7]

General Information

Symbol

Dmel\Wnt5^D7

Species

D. melanogaster

Name

FlyBase ID

FBal0144486

Feature type

allele

Associated gene

Dmel\Wnt5

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Yoshikawa et al., 2003)

Progenitor genotype

Wnt5^BG00642

(Yoshikawa et al., 2003)

Cytology

Description

Imprecise excision of the P{GT1} insertion has created a 1,251 bp deletion that removes the first 261 amino acids of the Wnt5 coding region.

(Yoshikawa et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Sakurai et al., 2009)

fertile

(Yoshikawa et al., 2003)

uncoordinated

(Yoshikawa et al., 2003)

viable

(Yoshikawa et al., 2003)

Phenotype Manifest In

antennal lobe

(Sakurai et al., 2009)

glomerulus

(Sakurai et al., 2009)

larval anterior commissure

(Yoshikawa et al., 2003)

presumptive embryonic salivary gland

(Harris and Beckendorf, 2007)

Detailed Description

Statement

Reference

Wnt5^D7 mutant adult brains often lack the commissure between the antennal lobes, that resemble inverted triangles, in contrast to being globular as in wild-type. In Wnt5^D7 mutants, many of the glomeruli are located in the periphery of the antennal lobe are rotated in a clockwise manner in the right antennal lobe.

(Sakurai et al., 2009)

The tips of the salivary glands curve ventromedially towards the central nervous system in approximately 40% of Wnt5^D7 embryos, instead of lying parallel to the midline as in wild-type embryos.

(Harris and Beckendorf, 2007)

Mutant adults are uncoordinated. Mutant embryos have disorganised commissures. In many segments commissures appear irregular, and there are often abnormal axonal projections between the anterior and posterior commissures (AC and PC). In these cases it is the AC whose projections are defective. 80% of segments display abnormal projections of AC axons into the PC.

(Yoshikawa et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Wnt5^D7 is a suppressor of abnormal neurophysiology phenotype of Scer\GAL4^eg-Mz360, drl^UAS.cCa

(Yoshikawa et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Wnt5^D7 has presumptive embryonic salivary gland phenotype, enhanceable by Wnt4^EMS23

(Harris and Beckendorf, 2007)

Enhancer of

Statement

Reference

Wnt5^D7 is an enhancer of presumptive embryonic salivary gland phenotype of Wnt4^EMS23

(Harris and Beckendorf, 2007)

Suppressor of

Statement

Reference

Wnt5^D7 is a suppressor of interneuron phenotype of Scer\GAL4^eg-Mz360, drl^UAS.cCa

(Yoshikawa et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The salivary glands of Wnt5^D7 ; drl^R343 double homozygous embryos show the same phenotype with similar penetrance as that seen in either of the single mutants alone.

Wnt5^D7 ; drl^R343 double heterozygotes show salivary gland guidance defects; the salivary glands curve ventromedially towards the central nervous system, instead of lying parallel to the midline as in wild-type embryos.

Wnt5^D7 ; Wnt4^EMS23 double mutants have a higher penetrance of salivary gland curving than is seen in either of the single mutants alone.

(Harris and Beckendorf, 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Wnt5^D7

(Yasunaga et al., 2015, Shimizu et al., 2011, Sakurai et al., 2009, Harris and Beckendorf, 2007)

wnt5^D7

(Zhu et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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