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General Information
Symbol
Dmel\drlRed2
Species
D. melanogaster
Name
FlyBase ID
FBal0102745
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{etau-lacZ}drlRed2
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In 36% of the hemisegments of drlRed2 stage 16 embryos, lateral transverse muscles (LTMs) bypass their normal attachment at the epidermis at muscle 12 and instead extend ventrally beyond muscle 13 and attach at a novel epidermal site located close to muscle fiber 7. This phenotype is usually only seen in one the three muscles per hemisegment. This LTM overextension phenotype is seen in 16% of third instar larvae.

In 50%% of hemisegments in drlRed2/Df(2L)Exel6043 the lateral transverse muscles (LTMs) bypass their normal attachment at the epidermis at muscle 12 and instead extend ventrally beyond muscle 13 and attach at a novel epidermal site located close to muscle fiber 7.

In 50%% of hemisegments in drlRed2/Df(2L)ED1231 the lateral transverse muscles (LTMs) bypass their normal attachment at the epidermis at muscle 12 and instead extend ventrally beyond muscle 13 and attach at a novel epidermal site located close to muscle fiber 7.

The epidermal clusters of tendon cell precursors in stage 11/12 drlRed2 mutant embryos are similar in size and location to wild type clusters.

Anterior commissure (AC) axons project normally and never enter the posterior commissure (PC) in heterozygous embryos. In homozygous embryos, 34% of segments have AC axons that project entirely through the PC, as well as axons that leave the AC and enter the PC near the midline.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement
Reference

drl[+]/drlRed2 is a non-enhancer of abnormal neuroanatomy | dominant | adult stage phenotype of tapGal4

Phenotype Manifest In
NOT Enhanced by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

drlRed2/+ or sli2/+ does not significantly enhance frequency of mushroom body beta lobe axon overgrowth defects in tapGal4/+ brains.

In 36% of the hemisegments in drlRed2 Wnt5400 double mutant embryos, the lateral transverse muscles (LTMs) bypass their normal attachment at the epidermis at muscle 12 and instead extend ventrally beyond muscle 13 and attach at a novel epidermal site located close to muscle fiber 7. This is similar to the number seen in drlRed2 single mutants, but significantly more than is seen in Wnt5400 mutants.

Drl-2E124 does not enhance the lateral transverse muscle attachment defects seen in drlRed2 mutant stage 16 embryos.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Not rescued by
Comments

Expression of drlScer\UAS.cCa under the control of Scer\GAL4Mef2.PR rescues the lateral transverse muscle attachment defects seen in drlRed2 mutant stage 16 embryos. No rescue is seen when drlScer\UAS.cCa is expressed under the control of Scer\GAL4sr-md710.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)