Yuan, L., Hu, S., Okray, Z., Ren, X., De Geest, N., Claeys, A., Yan, J., Bellefroid, E., Hassan, B.A., Quan, X.J. (2016). The Drosophila neurogenin Tap functionally interacts with the Wnt-PCP pathway to regulate neuronal extension and guidance.  Development 143(15): 2760--2766.

FBrf0233039

Research paper

The neurogenin (Ngn) transcription factors control early neurogenesis and neurite outgrowth in mammalian cortex. In contrast to their proneural activity, their function in neurite growth is poorly understood. Drosophila has a single predicted Ngn homolog, Tap, of unknown function. Here we show that Tap is not a proneural protein in Drosophila but is required for proper axonal growth and guidance of neurons of the mushroom body, a neuropile required for associative learning and memory. Genetic and expression analyses suggest that Tap inhibits excessive axonal growth by fine regulation of the levels of the Wnt signaling adaptor protein Dishevelled.

PMC5004907 (PMC) (EuropePMC)