FlyBase Allele Report: Dmel\dsh[6]

General Information

Symbol

Dmel\dsh⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0003143

Feature type

allele

Associated gene

Dmel\dsh

Associated Insertion(s)

Carried in Construct

Also Known As

dsh^M20

Key Links

Allele class

loss of function allele

hypomorphic allele - genetic evidence

amorphic allele - genetic evidence

Mutagen

ethyl nitrosourea

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Perrimon and Mahowald, 1987)

hypomorphic allele - genetic evidence

(Klingensmith et al., 1994)

loss of function allele

(Srahna et al., 2006)

Mutagen

ethyl nitrosourea

(Perrimon and Mahowald, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Heterozygous dsh⁶ mutant flies show dorsal cluster neuron branching defects in the adult medulla; the number of branches at the 3rd branching point of the grid-like structure is significantly increased.

(Vandewalle et al., 2013)

The average number of dorsal cluster neurons that cross between the lobula and the medulla is reduced from the wild-type number of 11.7 to 7.6 in the brains of dsh⁶/+ mutants.

(Srahna et al., 2006)

Homozygous larvae grown at the restrictive temperature result in heads that lack both the lateral and mediolateral structures causing the ocelli to be directly adjacent to the compound eyes. Ocellar cuticle and the ocelli are larger than wild type.

(Royet and Finkelstein, 1996)

Hemizygotes lack antennal structures and have bulbous, truncated legs. Legs show a deletion of ventral markers replaced with a duplication of dorsal pattern elements. 20% of mutants are lacking one, or both wings and have a duplicated notum.

(Klingensmith et al., 1994)

Females possessing homozygous germline clones when mated to wild type males produce two classes of embryos: heterozygous females are fertile and morphogenetically normal and hemizygous male embryos lack dorsal cuticle, posterior spiracles and filzkorper material. The ventral cuticle present has no naked cuticle in the thoracic or abdominal segments. Embryos show an aberrant pattern of cell death and lack of parasegmental and segmental boundaries.

(Perrimon and Mahowald, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

dsh[+]/dsh⁶ is an enhancer of abnormal neuroanatomy | adult stage | dominant phenotype of tap^Gal4

(Yuan et al., 2016)

NOT Enhancer of

Statement

Reference

dsh[+]/dsh⁶ is a non-enhancer of visible | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

dsh[+]/dsh⁶ is a non-enhancer of decreased size | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

dsh⁶ is a non-enhancer of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

dsh⁶ is a non-enhancer of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

dsh⁶ is a non-enhancer of visible phenotype of Ret^GMR.PR

(Read et al., 2005)

Suppressor of

Statement

Reference

dsh[+]/dsh⁶ is a suppressor of abnormal size phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

dsh[+]/dsh⁶ is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

dsh[+]/dsh⁶ is a suppressor of visible phenotype of CycE^JP

(Brumby et al., 2004)

NOT Suppressor of

Statement

Reference

dsh[+]/dsh⁶ is a non-suppressor of visible | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

dsh[+]/dsh⁶ is a non-suppressor of decreased size | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

dsh⁶ is a non-suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

dsh⁶ is a non-suppressor of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

dsh⁶ is a non-suppressor of visible phenotype of Ret^GMR.PR

(Read et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

dsh[+]/dsh⁶ is an enhancer of adult mushroom body beta-lobe | adult stage phenotype of tap^Gal4

(Yuan et al., 2016)

dsh[+]/dsh⁶ is an enhancer of adult mushroom body alpha-lobe | adult stage phenotype of tap^Gal4

(Yuan et al., 2016)

NOT Enhancer of

Statement

Reference

dsh[+]/dsh⁶ is a non-enhancer of eye phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

dsh⁶ is a non-enhancer of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

dsh⁶ is a non-enhancer of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

dsh⁶ is a non-enhancer of eye phenotype of Ret^GMR.PR

(Read et al., 2005)

Suppressor of

Statement

Reference

dsh[+]/dsh⁶ is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

dsh[+]/dsh⁶ is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

NOT Suppressor of

Statement

Reference

dsh[+]/dsh⁶ is a non-suppressor of eye phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

dsh⁶ is a non-suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

dsh⁶ is a non-suppressor of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

dsh⁶ is a non-suppressor of eye phenotype of Ret^GMR.PR

(Read et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

dsh⁶/+ significantly enhances frequency of mushroom body beta lobe axon overgrowth defects (midline crossing) and missing alpha lobes in tap^Gal4/+ brains.

(Yuan et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

108156

dsh⁶/FM7a

Notes on Origin

Discoverer

Voelker.

Comments

Mutant phenotypes is similar to that shown by wg mutants.

(Klingensmith et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

dsh6

(Vandewalle et al., 2013)

dsh⁶

(Lee et al., 2020, Yuan et al., 2016, Zhang et al., 2015, Vandewalle et al., 2013, Kuroda et al., 2012, Goossens et al., 2011, Srahna et al., 2006)

dsh^M20

(Royet and Finkelstein, 1996, Krasnow et al., 1995, Hooper, 1994, Klingensmith et al., 1994, van den Heuvel et al., 1993, Perrimon and Mahowald, 1987)

l(1)M20

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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