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General Information
Symbol
Dmel\dsh6
Species
D. melanogaster
Name
FlyBase ID
FBal0003143
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dshM20
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygous dsh6 mutant flies show dorsal cluster neuron branching defects in the adult medulla; the number of branches at the 3rd branching point of the grid-like structure is significantly increased.

The average number of dorsal cluster neurons that cross between the lobula and the medulla is reduced from the wild-type number of 11.7 to 7.6 in the brains of dsh6/+ mutants.

Homozygous larvae grown at the restrictive temperature result in heads that lack both the lateral and mediolateral structures causing the ocelli to be directly adjacent to the compound eyes. Ocellar cuticle and the ocelli are larger than wild type.

Hemizygotes lack antennal structures and have bulbous, truncated legs. Legs show a deletion of ventral markers replaced with a duplication of dorsal pattern elements. 20% of mutants are lacking one, or both wings and have a duplicated notum.

Females possessing homozygous germline clones when mated to wild type males produce two classes of embryos: heterozygous females are fertile and morphogenetically normal and hemizygous male embryos lack dorsal cuticle, posterior spiracles and filzkorper material. The ventral cuticle present has no naked cuticle in the thoracic or abdominal segments. Embryos show an aberrant pattern of cell death and lack of parasegmental and segmental boundaries.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

dsh[+]/dsh6 is an enhancer of abnormal neuroanatomy | dominant | adult stage phenotype of tapGal4

NOT Enhancer of
Statement
Reference

dsh6 is a non-enhancer of visible phenotype of RetMEN2B.GMR

dsh6 is a non-enhancer of visible phenotype of RetMEN2A.GMR

dsh6 is a non-enhancer of visible phenotype of RetGMR.PR

Suppressor of
Statement
Reference

dsh[+]/dsh6 is a suppressor | partially of visible phenotype of CycEJP

NOT Suppressor of
Statement
Reference

dsh6 is a non-suppressor of visible phenotype of RetMEN2B.GMR

dsh6 is a non-suppressor of visible phenotype of RetMEN2A.GMR

dsh6 is a non-suppressor of visible phenotype of RetGMR.PR

Phenotype Manifest In
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

dsh6 is a non-enhancer of eye phenotype of RetMEN2B.GMR

dsh6 is a non-enhancer of eye phenotype of RetMEN2A.GMR

dsh6 is a non-enhancer of eye phenotype of RetGMR.PR

Suppressor of
Statement
Reference

dsh[+]/dsh6 is a suppressor | partially of eye phenotype of CycEJP

NOT Suppressor of
Statement
Reference

dsh6 is a non-suppressor of eye phenotype of RetMEN2B.GMR

dsh6 is a non-suppressor of eye phenotype of RetMEN2A.GMR

dsh6 is a non-suppressor of eye phenotype of RetGMR.PR

Additional Comments
Genetic Interactions
Statement
Reference

dsh6/+ significantly enhances frequency of mushroom body beta lobe axon overgrowth defects (midline crossing) and missing alpha lobes in tapGal4/+ brains.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Voelker.

Comments
Comments

Mutant phenotypes is similar to that shown by wg mutants.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (15)