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General Information
Symbol
Dmel\RetGMR.PR
Species
D. melanogaster
Name
FlyBase ID
FBal0192090
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
GMR-dRetWT
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

GMR regulatory sequences drive expression of a full length, wild-type Ret cDNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of RetGMR.PR disturbs the normal array of ommatidia, creating a rough eye phenotype. The ommatidial remains normal, with four cone cells surrounded by two primary pigment cell, but supernumerary interommatidial cells are seen. In contrast to wild type, RetGMR.PR retinas contain virtually no apoptotic cells 28 hours after pupal formation.

Flies carrying one copy of RetGMR.PR have either no mutant phenotype or a mild rough eye phenotype. Flies carrying two copies of RetGMR.PR show a severe eye phenotype in which the eye becomes an irregular mass that bulges from the side of the head.

Expression of RetGMR.PR in the developing eye leads to overproliferation, alterations in cell fate differentiation, and ectopic cell death, giving rise to "rough" adult eyes consisting of fused, poorly patterned lenses and a reduction in the eyes' overall size.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

RetGMR.PR has visible phenotype, enhanceable by FakCG1/Fak[+]

RetGMR.PR has visible phenotype, enhanceable by FakCG1

RetGMR.PR has visible phenotype, enhanceable by Cskj1D8/Csk[+]

RetGMR.PR has visible phenotype, enhanceable by Df(1)lz-90b24/+

RetGMR.PR has visible phenotype, enhanceable by l(3)j2D5j2D5/l(3)j2D5[+]

RetGMR.PR has visible phenotype, enhanceable by msn[+]/msnj1E2

RetGMR.PR has visible phenotype, enhanceable by neur11

RetGMR.PR has visible phenotype, enhanceable by twsS049902/tws[+]

RetGMR.PR has visible phenotype, enhanceable by Df(1)sd72b/+

RetGMR.PR has visible phenotype, enhanceable by Df(2L)H20/+

RetGMR.PR has visible phenotype, enhanceable by Df(2L)TW137/+

RetGMR.PR has visible phenotype, enhanceable by Df(2L)TW50/+

RetGMR.PR has visible phenotype, enhanceable by Df(1)B25/+

RetGMR.PR has visible phenotype, enhanceable by Df(2L)cact-255rv64/+

RetGMR.PR has visible phenotype, enhanceable by Df(2R)vg-C/+

RetGMR.PR has visible phenotype, enhanceable by Df(3L)ZN47/+

RetGMR.PR has visible phenotype, enhanceable by Df(3R)M-Kx1/+

RetGMR.PR has visible phenotype, enhanceable by Df(3R)T-32/+

RetGMR.PR has visible phenotype, enhanceable by Df(3R)e-N19/+

RetGMR.PR has visible phenotype, enhanceable by Df(3R)e-R1/+

RetGMR.PR has visible phenotype, enhanceable by RasGAP1B2

RetGMR.PR has visible phenotype, enhanceable by In(2LR)DTD16LDTD42R/+

RetGMR.PR has visible phenotype, enhanceable by Mi-2S005504/Mi-2[+]

RetGMR.PR has visible phenotype, enhanceable by Df(1)C128/+

RetGMR.PR has visible phenotype, enhanceable by Mi-2S047526/Mi-2[+]

RetGMR.PR has visible phenotype, enhanceable by Mi-2S147412/Mi-2[+]

RetGMR.PR has visible phenotype, enhanceable by Pp1-87B1

RetGMR.PR has visible phenotype, enhanceable by Sin3A[+]/Sin3A08269

RetGMR.PR has visible phenotype, enhanceable by Sin3Aex4

RetGMR.PR has visible phenotype, enhanceable by Sin3Ak08919

RetGMR.PR has visible phenotype, enhanceable by bonS048706/bon[+]

RetGMR.PR has visible phenotype, enhanceable by crb07207

RetGMR.PR has visible phenotype, enhanceable by crbj1B5/crb[+]

RetGMR.PR has visible phenotype, enhanceable by hh[+]/hhrJ413

RetGMR.PR has visible phenotype, enhanceable by Df(1)KA14/+

RetGMR.PR has visible phenotype, enhanceable by l(3)S000718[+]/l(3)S000718S000718

RetGMR.PR has visible phenotype, enhanceable by l(3)S001405S001405/l(3)S001405[+]

RetGMR.PR has visible phenotype, enhanceable by l(3)S012805S012805/l(3)S012805[+]

RetGMR.PR has visible phenotype, enhanceable by l(3)S016805[+]/l(3)S016805S016805

RetGMR.PR has visible phenotype, enhanceable by l(3)S023549S090101/l(3)S023549[+]

RetGMR.PR has visible phenotype, enhanceable by l(3)S023901[+]/l(3)S023901S023901

RetGMR.PR has visible phenotype, enhanceable by l(3)S024329S024329/l(3)S024329[+]

RetGMR.PR has visible phenotype, enhanceable by l(3)S026238S026238/l(3)S026238[+]

RetGMR.PR has visible phenotype, enhanceable by l(3)S026421S026421/l(3)S026421[+]

RetGMR.PR has visible phenotype, enhanceable by l(3)S046604S046604/l(3)S046604[+]

RetGMR.PR has visible phenotype, enhanceable by Df(1)RA2/+

RetGMR.PR has visible phenotype, enhanceable by l(3)S056113[+]/l(3)S056113S056113

RetGMR.PR has visible phenotype, enhanceable by l(3)S057101[+]/l(3)S057101S057101

RetGMR.PR has visible phenotype, enhanceable by l(3)S066607[+]/l(3)S066607S066607

RetGMR.PR has visible phenotype, enhanceable by l(3)S068808S068808/l(3)S068808[+]

RetGMR.PR has visible phenotype, enhanceable by l(3)S081003S145911/l(3)S081003[+]

RetGMR.PR has visible phenotype, enhanceable by l(3)S090114[+]/l(3)S090114S090114

RetGMR.PR has visible phenotype, enhanceable by l(3)S092708[+]/l(3)S092708S092708

RetGMR.PR has visible phenotype, enhanceable by l(3)S133117[+]/l(3)S133117S133117

RetGMR.PR has visible phenotype, enhanceable by l(3)S135703S135703/l(3)S135703[+]

RetGMR.PR has visible phenotype, enhanceable by l(3)S142909S142909/l(3)S142909[+]

NOT Enhanced by
Statement
Reference

RetGMR.PR has visible phenotype, non-enhanceable by +/Df(3R)Dl-BX12

RetGMR.PR has visible phenotype, non-enhanceable by S[+]/Sk09538a

RetGMR.PR has visible phenotype, non-enhanceable by drkk02401

RetGMR.PR has visible phenotype, non-enhanceable by dsh6

RetGMR.PR has visible phenotype, non-enhanceable by kis[+]/kisk10237

RetGMR.PR has visible phenotype, non-enhanceable by kisk13416

RetGMR.PR has visible phenotype, non-enhanceable by ksrS-627

RetGMR.PR has visible phenotype, non-enhanceable by l(3)S023708[+]/l(3)S023708S023708

RetGMR.PR has visible phenotype, non-enhanceable by neur3

Suppressed by
Statement
Reference

RetGMR.PR has visible phenotype, suppressible by Df(2L)TW161/+

RetGMR.PR has visible phenotype, suppressible by Df(2L)al/+

RetGMR.PR has visible phenotype, suppressible by Df(2L)net-PMF/+

RetGMR.PR has visible phenotype, suppressible by +/Df(2R)59AD

RetGMR.PR has visible phenotype, suppressible by Df(2R)AA21/+

RetGMR.PR has visible phenotype, suppressible by Df(2R)CX1/+

RetGMR.PR has visible phenotype, suppressible by Df(2R)P34/+

RetGMR.PR has visible phenotype, suppressible by Df(2R)Pu-D17/+

RetGMR.PR has visible phenotype, suppressible by Df(2R)ST1/+

RetGMR.PR has visible phenotype, suppressible by Df(2R)X58-12/+

RetGMR.PR has visible phenotype, suppressible by Df(3L)Pc-2q/+

RetGMR.PR has visible phenotype, suppressible by Df(3R)Antp17/+

RetGMR.PR has visible phenotype, suppressible by Df(3R)Cha7/+

RetGMR.PR has visible phenotype, suppressible by Df(3R)DG2/+

RetGMR.PR has visible phenotype, suppressible by Df(3R)Hu/+

RetGMR.PR has visible phenotype, suppressible by Df(3R)ME15/+

RetGMR.PR has visible phenotype, suppressible by JraIA109

RetGMR.PR has visible phenotype, suppressible by drk10626

RetGMR.PR has visible phenotype, suppressible by drkk13809

RetGMR.PR has visible phenotype, suppressible by ebi[+]/ebik16213

RetGMR.PR has visible phenotype, suppressible by ksrj5E2

RetGMR.PR has visible phenotype, suppressible by l(3)S009515[+]/l(3)S009515S009515

RetGMR.PR has visible phenotype, suppressible by px[+]/pxk08316

NOT suppressed by
Statement
Reference

RetGMR.PR has visible phenotype, non-suppressible by +/Df(3R)Dl-BX12

RetGMR.PR has visible phenotype, non-suppressible by kisk13416

RetGMR.PR has visible phenotype, non-suppressible by ksrS-627

RetGMR.PR has visible phenotype, non-suppressible by l(3)S023708[+]/l(3)S023708S023708

RetGMR.PR has visible phenotype, non-suppressible by neur3

RetGMR.PR has visible phenotype, non-suppressible by S[+]/Sk09538a

RetGMR.PR has visible phenotype, non-suppressible by drkk02401

RetGMR.PR has visible phenotype, non-suppressible by dsh6

RetGMR.PR has visible phenotype, non-suppressible by kis[+]/kisk10237

Suppressor of
Statement
Reference

RetGMR.PR is a suppressor | partially of visible phenotype of hidGMR.PG

Phenotype Manifest In
Enhanced by
Statement
Reference

RetGMR.PR has eye phenotype, enhanceable by FakCG1/Fak[+]

RetGMR.PR has eye phenotype, enhanceable by FakCG1

RetGMR.PR has eye phenotype, enhanceable by Cskj1D8/Csk[+]

RetGMR.PR has eye phenotype, enhanceable by l(3)j2D5j2D5/l(3)j2D5[+]

RetGMR.PR has eye phenotype, enhanceable by msn[+]/msnj1E2

RetGMR.PR has eye phenotype, enhanceable by neur11

RetGMR.PR has eye phenotype, enhanceable by twsS049902/tws[+]

RetGMR.PR has eye phenotype, enhanceable by Df(1)lz-90b24/+

RetGMR.PR has eye phenotype, enhanceable by Df(1)sd72b/+

RetGMR.PR has eye phenotype, enhanceable by Df(2L)H20/+

RetGMR.PR has eye phenotype, enhanceable by Df(2L)TW137/+

RetGMR.PR has eye phenotype, enhanceable by Df(2L)TW50/+

RetGMR.PR has eye phenotype, enhanceable by Df(2L)cact-255rv64/+

RetGMR.PR has eye phenotype, enhanceable by Df(2R)vg-C/+

RetGMR.PR has eye phenotype, enhanceable by Df(3L)ZN47/+

RetGMR.PR has eye phenotype, enhanceable by Df(3R)M-Kx1/+

RetGMR.PR has eye phenotype, enhanceable by Df(3R)T-32/+

RetGMR.PR has eye phenotype, enhanceable by Df(1)B25/+

RetGMR.PR has eye phenotype, enhanceable by Df(3R)e-N19/+

RetGMR.PR has eye phenotype, enhanceable by Df(3R)e-R1/+

RetGMR.PR has eye phenotype, enhanceable by RasGAP1B2

RetGMR.PR has eye phenotype, enhanceable by In(2LR)DTD16LDTD42R/+

RetGMR.PR has eye phenotype, enhanceable by Mi-2S005504/Mi-2[+]

RetGMR.PR has eye phenotype, enhanceable by Mi-2S047526/Mi-2[+]

RetGMR.PR has eye phenotype, enhanceable by Mi-2S147412/Mi-2[+]

RetGMR.PR has eye phenotype, enhanceable by Pp1-87B1

RetGMR.PR has eye phenotype, enhanceable by Sin3A[+]/Sin3A08269

RetGMR.PR has eye phenotype, enhanceable by Sin3Aex4

RetGMR.PR has eye phenotype, enhanceable by Df(1)C128/+

RetGMR.PR has eye phenotype, enhanceable by Sin3Ak08919

RetGMR.PR has eye phenotype, enhanceable by bonS048706/bon[+]

RetGMR.PR has eye phenotype, enhanceable by crb07207

RetGMR.PR has eye phenotype, enhanceable by crbj1B5/crb[+]

RetGMR.PR has eye phenotype, enhanceable by hh[+]/hhrJ413

RetGMR.PR has eye phenotype, enhanceable by l(3)S000718[+]/l(3)S000718S000718

RetGMR.PR has eye phenotype, enhanceable by l(3)S001405S001405/l(3)S001405[+]

RetGMR.PR has eye phenotype, enhanceable by l(3)S012805S012805/l(3)S012805[+]

RetGMR.PR has eye phenotype, enhanceable by l(3)S016805[+]/l(3)S016805S016805

RetGMR.PR has eye phenotype, enhanceable by l(3)S023549S090101/l(3)S023549[+]

RetGMR.PR has eye phenotype, enhanceable by Df(1)KA14/+

RetGMR.PR has eye phenotype, enhanceable by l(3)S023901[+]/l(3)S023901S023901

RetGMR.PR has eye phenotype, enhanceable by l(3)S024329S024329/l(3)S024329[+]

RetGMR.PR has eye phenotype, enhanceable by l(3)S026238S026238/l(3)S026238[+]

RetGMR.PR has eye phenotype, enhanceable by l(3)S026421S026421/l(3)S026421[+]

RetGMR.PR has eye phenotype, enhanceable by l(3)S046604S046604/l(3)S046604[+]

RetGMR.PR has eye phenotype, enhanceable by l(3)S056113[+]/l(3)S056113S056113

RetGMR.PR has eye phenotype, enhanceable by l(3)S057101[+]/l(3)S057101S057101

RetGMR.PR has eye phenotype, enhanceable by l(3)S066607[+]/l(3)S066607S066607

RetGMR.PR has eye phenotype, enhanceable by l(3)S068808S068808/l(3)S068808[+]

RetGMR.PR has eye phenotype, enhanceable by l(3)S081003S145911/l(3)S081003[+]

RetGMR.PR has eye phenotype, enhanceable by Df(1)RA2/+

RetGMR.PR has eye phenotype, enhanceable by l(3)S090114[+]/l(3)S090114S090114

RetGMR.PR has eye phenotype, enhanceable by l(3)S092708[+]/l(3)S092708S092708

RetGMR.PR has eye phenotype, enhanceable by l(3)S133117[+]/l(3)S133117S133117

RetGMR.PR has eye phenotype, enhanceable by l(3)S135703S135703/l(3)S135703[+]

RetGMR.PR has eye phenotype, enhanceable by l(3)S142909S142909/l(3)S142909[+]

NOT Enhanced by
Statement
Reference

RetGMR.PR has eye phenotype, non-enhanceable by +/Df(3R)Dl-BX12

RetGMR.PR has eye phenotype, non-enhanceable by S[+]/Sk09538a

RetGMR.PR has eye phenotype, non-enhanceable by drkk02401

RetGMR.PR has eye phenotype, non-enhanceable by dsh6

RetGMR.PR has eye phenotype, non-enhanceable by kis[+]/kisk10237

RetGMR.PR has eye phenotype, non-enhanceable by kisk13416

RetGMR.PR has eye phenotype, non-enhanceable by ksrS-627

RetGMR.PR has eye phenotype, non-enhanceable by l(3)S023708[+]/l(3)S023708S023708

RetGMR.PR has eye phenotype, non-enhanceable by neur3

Suppressed by
Statement
Reference

RetGMR.PR has eye phenotype, suppressible by Df(2L)TW161/+

RetGMR.PR has eye phenotype, suppressible by Df(2L)al/+

RetGMR.PR has eye phenotype, suppressible by Df(2L)net-PMF/+

RetGMR.PR has eye phenotype, suppressible by +/Df(2R)59AD

RetGMR.PR has eye phenotype, suppressible by Df(2R)AA21/+

RetGMR.PR has eye phenotype, suppressible by Df(2R)CX1/+

RetGMR.PR has eye phenotype, suppressible by Df(2R)P34/+

RetGMR.PR has eye phenotype, suppressible by Df(2R)Pu-D17/+

RetGMR.PR has eye phenotype, suppressible by Df(2R)ST1/+

RetGMR.PR has eye phenotype, suppressible by Df(2R)X58-12/+

RetGMR.PR has eye phenotype, suppressible by Df(3L)Pc-2q/+

RetGMR.PR has eye phenotype, suppressible by Df(3R)Antp17/+

RetGMR.PR has eye phenotype, suppressible by Df(3R)Cha7/+

RetGMR.PR has eye phenotype, suppressible by Df(3R)DG2/+

RetGMR.PR has eye phenotype, suppressible by Df(3R)Hu/+

RetGMR.PR has eye phenotype, suppressible by Df(3R)ME15/+

RetGMR.PR has eye phenotype, suppressible by JraIA109

RetGMR.PR has eye phenotype, suppressible by drk10626

RetGMR.PR has eye phenotype, suppressible by drkk13809

RetGMR.PR has eye phenotype, suppressible by ebi[+]/ebik16213

RetGMR.PR has eye phenotype, suppressible by ksrj5E2

RetGMR.PR has eye phenotype, suppressible by l(3)S009515[+]/l(3)S009515S009515

RetGMR.PR has eye phenotype, suppressible by px[+]/pxk08316

NOT suppressed by
Statement
Reference

RetGMR.PR has eye phenotype, non-suppressible by +/Df(3R)Dl-BX12

RetGMR.PR has eye phenotype, non-suppressible by kisk13416

RetGMR.PR has eye phenotype, non-suppressible by ksrS-627

RetGMR.PR has eye phenotype, non-suppressible by l(3)S023708[+]/l(3)S023708S023708

RetGMR.PR has eye phenotype, non-suppressible by neur3

RetGMR.PR has eye phenotype, non-suppressible by S[+]/Sk09538a

RetGMR.PR has eye phenotype, non-suppressible by drkk02401

RetGMR.PR has eye phenotype, non-suppressible by dsh6

RetGMR.PR has eye phenotype, non-suppressible by kis[+]/kisk10237

Suppressor of
Statement
Reference

RetGMR.PR is a suppressor | partially of eye phenotype of hidGMR.PG

Other
Additional Comments
Genetic Interactions
Statement
Reference

Heterozygous FakCG1 enhances the ommatidial mis-patterning seen in eyes expressing RetGMR.PR. Homozygous FakCG1 causes a smaller eye due to a completely disrupted ommatidial pattern. This enhancement is reversed upon co-expression of either FakScer\UAS.T:Ivir\HA1 or FakY430F.Scer\UAS under the control of Scer\GAL4GMR.PU.

The retinas of pupae (42 hours after pupal formation) expressing RetGMR.PR in a homozygous FakCG1 mutant background lack the hexagonal array and identifiable ommatidial units. Numerous ct-positive cone cells are seen. Some bristle cells and a few cells recognisable as primary pigment cells remain, but there are no detectable cells with the appearance of normal interommatidial cells. Ommatidial units with extranumerary cone cells are also seen at early stages of development (4 hours after pupal development). Eye discs contain normal number of photoreceptors, albeit some clusters have rotation defects.

Expression of FakScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU suppresses the rough eye phenotype seen upon expression of RetGMR.PR. The reduction in retinal apoptosis is also rescued.

Expression of RetGMR.PR partially suppresses the reduction in eye size seen in flies expressing hidGMR.PG. This suppression is partially reversed when FakScer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PU.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
RetGMR.PR
Name Synonyms
Secondary FlyBase IDs
    References (3)