FlyBase Allele Report: Dmel\neur[11]

neur¹¹ late stage 10 embryos exhibit an excess number of Asense-positive interstitial cell precursors, and present defects in posterior midgut remodeling, as shown by significantly fewer PGCs migrating through the posterior midgut epithelium, as compared to controls.

(Perez-Mockus et al., 2017)

Homozygous intestinal stem cell clones contain few polyploid enterocytes.

(Bardin et al., 2010)

Within neur¹¹ clones, an apical actin-rich structure (ARS) is formed normally in all SOP progeny.

(Rajan et al., 2009)

Homozygous intestinal stem cell (ISC) clones in the adult midgut either form tumours or differentiate into a single enterocyte.

(Ohlstein and Spradling, 2007)

Significantly fewer neur¹¹ homozygous mutant germline stem cell clones survive compared to wild-type clones, indicating that neur is necessary for germline stem cell maintenance. Examination of the mutant germline stem cells reveals that they are phenotypically identical to wild-type.

(Terry et al., 2006)

neur¹¹ clones in the adult notum are bald.

(Lai et al., 2005)

Ommatidia in neur¹¹ homozygous clones in the adult eye contain extra photoreceptor cells.

(Overstreet et al., 2004)

The progeny of neur¹¹ mutant pI cells produce no external sensory structures indicating that pIIa cells have been transformed into pIIb-like cells. Mitotic recombination of neur¹¹/+ mutants, induced at 0-6 hours before puparium formation, produces flies with double-shaft bristles on the head, thorax and at the wing margin. This double-shaft phenotype appears to result from wild-type pIIb/neur¹¹ mutant pIIa pairs because sensory organs composed of two mutant shaft cells (and no socket) with wild-type pIIb progeny cells are detected 20 hours after puparium formation. Reciprocally, a sheath-to-neuron transformation is observed in neur¹¹ mutant pIIb/ wild-type pIIa pairs. neur¹¹ mutant clones lead to the specification of a large excess of pI cells in the developing notum.

(Le Borgne and Schweisguth, 2003)

Mutants show no obvious mushroom body defect.

(Watts et al., 2003)

Homozygous somatic clones in the notum fail to differentiate the external components of sensory organs resulting in bald cuticle. Homozygous somatic clones in the sensory lineage can result in the transformation of the socket cell into a shaft cell. Homozygous somatic clones in the wing lead to either patches of anterior wing margin completely lacking in triple row bristles or triple row bristles with double shafts.

(Lai and Rubin, 2001)

Flies carrying homozygous somatic clones in the eye die during pupal development - large necrotic patches are seen the eyes of these pupae by 45 hours after puparium formation. Their ommatidia are poorly defined, lenses are not properly secreted and all interommatidial bristle structures are missing. The arrangement and morphology of the rhabdomeres are severely disrupted in a cell autonomous fashion.

(Lai and Rubin, 2001)

Mutant embryos show hypertrophy of the nervous system. neur¹¹ embryos carrying neur^{T42.Scer\UAS.T:Hsap\MYC} expressed under the control of Scer\GAL4^ptc-559.1 have a greatly reduced nervous system.

(Yeh et al., 2001)

Homozygous mutant embryos display sever hyperplasia to the central nervous system. Homozygous mutant clones give rise to a balding phenotype characterised by the absence of chaetae on the adult notum. When the pupal notum is examined, futsch expression reveals clusters of sensory organ precursors sometime containing up to four cells that differentiate to assume neural cell fates.

(Yeh et al., 2000)

The number of cells in the nau-expressing muscle precursor clusters is increased compared to wild-type in homozygous embryos and in homozygous embryos derived from homozygous female germline clones (lacking both maternal and zygotic function). The medial clusters expand across the midline.

(Rusconi and Corbin, 1998)

Homozygous embryos have an increased number of cardiac precursor cells.

(Jagla et al., 1997)

Thickened vein mutant.

(Sturtevant and Bier, 1995)

Embryos exhibit few, if any, fused muscles. The unfused, birefringent fibres, may have a patterned arrangement. The birefringent is clearly correlated with the expansion of the CNS and PNS, and the loss of epidermis and the degree to which myoblast fusion occurs. Where myoblast fusion fails conspicuous clusters of mesodermal cells are formed and if epidermal territories are expanded cells in these clusters may be recruited to fusion.

(Bate et al., 1993)

Extreme neurogenic phenotype.

(Lieber et al., 1993)

neur¹¹ shows severe neural hypertrophy, a 6--9 fold increase in nau expressing cells per cluster relative to wild type. The clusters enlarge so much that they merge to form superclusters across the midline.

(Corbin et al., 1991)

neur¹¹ expression was modified by the presence of ASC loss-of-function mutations.

(Brand and Campos-Ortega, 1988)

Severity of the phenotype is increased by duplication of Dl⁺ and decreased by triploidy for N.

(de la Concha et al., 1988)

Cold sensitive.

(Tearle and Nusslein-Volhard, 1987)

Homozygous clones in the eye have a severely disturbed ommatidial pattern, visible as a scar in the eye surface. Ommatidia are larger than wild-type and interommatidial bristles are missing. Each ommatidium contains more retinula cells and fewer pigment cells than wild-type. Each ommatidium contains more receptor cells than normal, and may contain up to 13 receptor cells. Homozygous clones in the cuticle lack all bristles.

(Dietrich and Campos-Ortega, 1984)

Extreme embryonic neurogenic phenotype. Only remaining epidermis is indicated by a patch of dorsal cuticle in which the posterior spiracles and a rudimentary anal plate are evident.

(Lehmann et al., 1983)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

neur¹¹ is an enhancer of visible phenotype of Ret^GMR.PR

(Read et al., 2005)

NOT Enhancer of

Statement

Reference

neur¹¹ is a non-enhancer of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

neur¹¹ is a non-enhancer of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

Suppressor of

Statement

Reference

neur[+]/neur¹¹ is a suppressor of visible | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

NOT Suppressor of

Statement

Reference

neur¹¹ is a non-suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

neur¹¹ is a non-suppressor of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

Phenotype Manifest In

Suppressed by

Statement

Reference

neur¹¹ has external sensory organ precursor cell IIa phenotype, suppressible by mib1^{UAS.Tag:polyHis,Tag:MYC}/Scer\GAL4^sca-537.4

(Lai et al., 2005)

neur¹¹ has eye | somatic clone phenotype, suppressible by H²

(Dietrich and Campos-Ortega, 1984)

Enhancer of

Statement

Reference

neur[+]/neur¹¹ is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, fru^NP0021

(Goto et al., 2011)

neur¹¹ is an enhancer of eye phenotype of Ret^GMR.PR

(Read et al., 2005)

neur¹¹ is an enhancer of phenotype of Brd¹

(Leviten and Posakony, 1996)

neur¹¹ is an enhancer of phenotype of Brd³

(Leviten and Posakony, 1996)

NOT Enhancer of

Statement

Reference

neur¹¹ is a non-enhancer of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

neur¹¹ is a non-enhancer of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

Suppressor of

Statement

Reference

neur[+]/neur¹¹ is a suppressor of wing vein | ectopic | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

neur[+]/neur¹¹ is a suppressor of wing | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

NOT Suppressor of

Statement

Reference

neur¹¹ is a non-suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

neur¹¹ is a non-suppressor of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

neur¹¹ is a non-suppressor of phenotype of Src42A^Su(Raf)1-1

(Zhang et al., 1999)

neur¹¹ is a non-suppressor of phenotype of sno^71e3

(Coyle-Thompson and Banerjee, 1993)

Other

Statement

Reference

Scer\GAL4^sca-537.4, mib1^{UAS.Tag:polyHis,Tag:MYC}, neur¹¹ has macrochaeta & mesothoracic tergum | somatic clone phenotype

(Lai et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

A neur¹¹ heterozygous background enhances the rough eye phenotype related to fru isoform B, found upon expression of fru^NP0021 under the control of Scer\GAL4^GMR.PF.

(Goto et al., 2011)

Expression of mib1^{Scer\UAS.T:Zzzz\His6,T:Hsap\MYC} under the control of Scer\GAL4^sca-537.4 rescues bald neur¹¹ clones back to a mild bristle tufting phenotype. Staining at the sensory precursor level shows that mib1^{Scer\UAS.T:Zzzz\His6,T:Hsap\MYC} expression rescues pIIa specification in neur¹¹ clones.

(Lai et al., 2005)

The number of photoreceptors per ommatidium in lqf^FDD9/lqf^FDD9 flies is increased still further by neur¹¹/+.

(Overstreet et al., 2004)

Does not suppress the ability of Src42A^Su(phl)1-1 to suppress the lethality of phl¹/Y flies.

(Zhang et al., 1999)

There is no detectable dominant interaction with sno^71e3.

(Coyle-Thompson and Banerjee, 1993)

Not capable of rescuing the lethality conferred N^Ax-E2/N^Ax-9 heterozygotes.

(Xu et al., 1990)

H² reduces the severity of the phenotype of neur¹¹ clones in the eye.

(Dietrich and Campos-Ortega, 1984)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

neur¹¹ is partially rescued by Scer\GAL4^ptc-559.1/neur^UAS.cYa

(Yeh et al., 2001)

neur¹¹ is partially rescued by Scer\GAL4^ptc-559.1/neur^UAS.Tag:MYC

(Yeh et al., 2001)

neur¹¹ is partially rescued by Scer\GAL4^ptc-559.1/neur^UAS.cYa

(Yeh et al., 2000)

neur¹¹ is partially rescued by Scer\GAL4^ptc-559.1/neur^UAS.Tag:MYC

(Yeh et al., 2000)

Not rescued by

neur¹¹ is not rescued by Scer\GAL4^ptc-559.1/neur^{T42.UAS.Tag:MYC}

(Yeh et al., 2001)

neur¹¹ is not rescued by Scer\GAL4^ptc-559.1/neur^{T22.UAS.Tag:MYC}

(Yeh et al., 2001)

neur¹¹ is not rescued by Scer\GAL4^ptc-559.1/neur^{C701S.UAS.Tag:MYC}

(Yeh et al., 2001)

Comments

The embryonic nervous system phenotype is partially rescued by neur^{Scer\UAS.T:Hsap\MYC} or neur^Scer\UAS.cYa when driven by Scer\GAL4^ptc-559.1. Ventral cuticle is also restored.

(Yeh et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (2)

2747

107457

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

Neur^1F65

(Rajan et al., 2009)

Neur^IF65

(Zhai et al., 2017)

neu¹¹

(Ohlstein and Spradling, 2007, Jack and Myette, 1999)

neu^IF

(Yamaguchi et al., 1994, Tearle and Nusslein-Volhard, 1987)

neur¹¹

(Arefin et al., 2019, Falo-Sanjuan et al., 2019, Shahab et al., 2015, Goto et al., 2011, Salzer et al., 2010, Terry et al., 2006)

neur^1F65

(Houssin et al., 2021, Roegiers et al., 2005, Le Borgne and Schweisguth, 2003)

neur^IF65

(Shard et al., 2020, Bellec et al., 2018, Kavaler et al., 2018, Miller and Posakony, 2018, Corson et al., 2017, Perez-Mockus et al., 2017, Patel et al., 2015, Miller et al., 2014, Liu et al., 2012, Bardin et al., 2010, Chanet et al., 2009, Bardin and Schweisguth, 2006, del Alamo and Mlodzik, 2006, Lai et al., 2005, Le Borgne et al., 2005, Johannes and Preiss, 2002, Lai and Rubin, 2001, Kooh et al., 1993)

neur^if65

(Vachias et al., 2010)

neuralized¹¹

(Ohlstein and Spradling, 2007)

Name Synonyms

Secondary FlyBase IDs

References (66)

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