FlyBase Allele Report: Dmel\neur[1]

General Information

Symbol

Dmel\neur¹

Species

D. melanogaster

Name

FlyBase ID

FBal0012940

Feature type

allele

Associated gene

Dmel\neur

Associated Insertion(s)

Carried in Construct

Also Known As

neu^9L119, neur^9L119

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Li and Baker, 2004, Leviten and Posakony, 1996)

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Carries a G-to-A transition in the second exon (residue numbering is in reference to the PA isoform of neur) resulting in a Gly167 to Glu substitution.

(Commisso and Boulianne, 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:9,023,617..9,023,617 [-]

Nucleotide change:

G9023617A

Reported nucleotide change:

G?A

Amino acid change:

Reported amino acid change:

G167E

(Commisso and Boulianne, 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory

(Pavlopoulos et al., 2008)

abnormal neuroanatomy | embryonic stage 11 (with neur¹¹)

(Arefin et al., 2019)

increased cell number | embryonic stage 11 (with neur¹¹)

(Arefin et al., 2019)

lethal - all die during embryonic stage | neurogenic phenotype | recessive

(Lehmann et al., 1983)

some die during embryonic stage | recessive

(Lehmann et al., 1983)

Phenotype Manifest In

dorsal-ventral compartment boundary of the wing disc

(Pavlopoulos et al., 2001)

embryonic/larval crystal cell

(Milchanowski et al., 2004)

embryonic epidermis

(Lehmann et al., 1983)

embryonic neuroblast | embryonic stage 11 | increased number (with neur¹¹)

(Arefin et al., 2019)

exit glial cell

(Nelson and Laughon, 1994)

eye photoreceptor cell | somatic clone

(Li and Baker, 2004)

germline stem cell | somatic clone

(Terry et al., 2006)

larval glial cell

(Nelson and Laughon, 1994)

larval somatic muscle cell

(Rusconi and Corbin, 1998)

larval somatic muscle cell | germline clone

(Rusconi and Corbin, 1998)

neuron & eye | supernumerary | somatic clone

(Li and Baker, 2001)

ommatidium | somatic clone

(Li and Baker, 2004)

PNS glial cell

(Nelson and Laughon, 1994)

sensory mother cell

(Pavlopoulos et al., 2001)

sensory mother cell | ectopic | somatic clone

(Pitsouli and Delidakis, 2005)

Detailed Description

Statement

Reference

neur¹/neur¹¹ stage 11 mutants exhibit an increase in the number of neuroblasts when compared to control embryos.

(Arefin et al., 2019)

neur¹ heterozygotes exhibit learning and 9-minute memory abilities that appear identical to wild-type controls. However, these animals display significantly reduced 260-minute memory.

(Pavlopoulos et al., 2008)

Significantly fewer neur¹ homozygous mutant germline stem cell clones survive compared to wild-type clones, indicating that neur is necessary for germline stem cell maintenance. Examination of the mutant germline stem cells reveals that they are phenotypically identical to wild-type.

(Terry et al., 2006)

neur¹ third instar nota clones exhibit at least eight sensory organ precursors (SOPs) in approximately 11% of SOP positions scored. Approximately 33.5% of SOP positions display between four and eight ectopic SOPs, while approximately 48% exhibit between one and four SOPs, with only 7.5% exhibiting one SOP, as in wild-type.

(Pitsouli and Delidakis, 2005)

The presence of neur¹ mutant cells within an ommatidium is often associated with changes in the number of photoreceptor cells: ommatidia with too many or too few photoreceptors are both observed. Less often, ommatidia containing one or more neur¹ cells differentiate 8 photoreceptor cells in the normal arrangement. Ommatidia almost never develop normally with a neur¹ R8 cell, and only rarely develop normally with a neur¹ R3 cell - when the R3 cell is neur¹ mutant, symmetrical ommatidia often develop, with two R3 cells in place of R3/R4. Ommatidia develop normally when the R7 is neur¹ mutant. R1 and R6 are never both mutant for neur¹ in normal ommatidia.

(Li and Baker, 2004)

The average number of crystal cells per embryo is reduced in homozygous stage 13-14 embryos compared to wild type.

(Milchanowski et al., 2004)

Homozygous mutant somatic clonesare neuorgenic in the eye.

(Li and Baker, 2001)

Sensory organ precursors (SOPs) at the prospective wing margin of third instar larval wing discs are lost in neur¹ somatic clones, except in cases where a cell within the clone abuts wild-type wing margin cells. There may be some non-autonomous effect of these clones on SOPs: 60% of the clones have wild-type (WT) SOPs next to neur¹ mutant non-SOPs; 18% of clones have WT non-SOPs next to neur¹ mutant SOPs; 23% have adjacent WT and neur¹ mutant SOPs. This is similar to the results obtained with Dl^RevF10 somatic clones.

(Pavlopoulos et al., 2001)

The number of cells in the nau-expressing muscle precursor clusters is increased compared to wild-type in homozygous embryos and in homozygous embryos derived from homozygous female germline clones (lacking both maternal and zygotic function).

(Rusconi and Corbin, 1998)

The number of peripheral, exit and dorsal roof glia in mutant embryos is higher than in wild-type embryos.

(Nelson and Laughon, 1994)

ac protein distribution in neur¹ embryos show ac expression is not restricted to a single cell of an ectodermal cell cluster, instead most cells of the cluster retain ac expression at a high level, enlarge, delaminate and become neuroblasts.

(Skeath and Carroll, 1992)

Extreme embryonic neurogenic phenotype.

(Lehmann et al., 1983)

strong allele embryonic lethal hyperplasia of neural components at the expense of epidermal components as seen in other neurogenic lethal mutations (N, bib, mam, etc.);

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

neur[+]/neur¹ is an enhancer of visible phenotype of Rala^EE1

(Cho and Fischer, 2011)

NOT Enhancer of

Statement

Reference

neur¹ is a non-enhancer of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

NOT Suppressor of

Statement

Reference

neur¹ is a non-suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Other

Statement

Reference

lqf^FDD9, neur[+]/neur¹ has lethal phenotype

(Overstreet et al., 2004)

lqf^FDD9, neur¹ has lethal phenotype

(Overstreet et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

neur¹ has sensory mother cell | ectopic phenotype, enhanceable by mib1^EY09780

(Pitsouli and Delidakis, 2005)

neur¹ has sensory mother cell | ectopic | somatic clone phenotype, enhanceable by Delta^RevF10

(Pitsouli and Delidakis, 2005)

neur¹ has sensory mother cell | ectopic | somatic clone phenotype, enhanceable by Ser^RX106

(Pitsouli and Delidakis, 2005)

neur¹ has sensory mother cell | ectopic | somatic clone phenotype, enhanceable by mib1^EY09780

(Pitsouli and Delidakis, 2005)

Enhancer of

Statement

Reference

neur[+]/neur¹ is an enhancer of eye phenotype of Rala^EE1

(Cho and Fischer, 2011)

neur¹ is an enhancer of sensory mother cell | third instar larval stage | ectopic | somatic clone phenotype of Delta^RevF10

(Pitsouli and Delidakis, 2005)

neur[+]/neur¹ is an enhancer of eye photoreceptor cell & ommatidium | ectopic phenotype of lqf^FDD9

(Overstreet et al., 2004)

neur[+]/neur¹ is an enhancer of dorsal vessel wall cell | increased number phenotype of lqf^ARI

(Tian et al., 2004)

neur¹ is an enhancer of phenotype of Brd¹

(Leviten and Posakony, 1996)

neur¹ is an enhancer of phenotype of Brd³

(Leviten and Posakony, 1996)

NOT Enhancer of

Statement

Reference

neur¹ is a non-enhancer of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

NOT Suppressor of

Statement

Reference

neur¹ is a non-suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype of Rala^EE1/Y adults is dominantly enhanced by neur¹.

(Cho and Fischer, 2011)

neur¹ Dl^RevF10 third instar nota clones exhibit at least eight sensory organ precursors (SOPs) in approximately 50% of SOP positions scored. Approximately 35% of SOP positions display between four and eight ectopic SOPs, while approximately 15% exhibit between one and four SOPs. No SOP positions appeared wild-type. Therefore neur enhances the Dl lateral inhibition phenotype. neur¹ Ser^RX106 third instar nota clones exhibit at least eight sensory organ precursors (SOPs) in approximately 33.5% of SOP positions scored. Approximately 47% of SOP positions display between four and eight ectopic SOPs, while approximately 19.5% exhibit between one and four SOPs. No SOP positions appeared wild-type. Therefore neur enhances the Ser lateral inhibition phenotype. mib1^EY09780 neur¹ third instar nota clones exhibit at least eight sensory organ precursors (SOPs) in approximately 82.5% of SOP positions scored. Approximately 17.5% of SOP positions display between four and eight ectopic SOPs. No wild-type SOPs are found. Induction of neur¹ mutant clones in a homozygous mib1^EY09780 background results in a large number of ectopic sensory organ precursors.

(Pitsouli and Delidakis, 2005)

Unlike lqf^FDD9/lqf^FDD9 animals, lqf^FDD9/lqf^FDD9; neur¹/+ die as larvae.

(Overstreet et al., 2004)

Heterozygosity for neur¹ increases the frequency of lqf^ARI embryos that show an excess cardioblast phenotype at 18^oC.

(Tian et al., 2004)

No significant effect on the sca^MSKF mutant phenotype.

(Hu et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

neur¹ is rescued by Scer\GAL4^c747/neur^UAS.cPa

(Pavlopoulos et al., 2008)

Comments

Expression of neur^Scer\UAS.cPa under the control of Scer\GAL4^c747 fully rescues 260-minute memory after conditioned and unconditioned stimuli pairings in neur¹ mutants.

(Pavlopoulos et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4222

ru¹ hry¹ Diap1^th-1 st¹ neur¹ cu¹ sr¹ e^s ca¹/TM3, Sb¹

Kyoto

107642

ru¹ hry¹ Diap1^th-1 st¹ neur¹ cu¹ sr¹ e^s ca¹/TM3, Sb¹

Notes on Origin

Discoverer

Nusslein-Volhard, Wieschaus.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

Neur¹

(Berndt et al., 2017)

neu¹

neu^9L119

(Rusconi and Corbin, 1998, Leviten and Posakony, 1996, Schmid et al., 1996, Hu et al., 1995, Nelson and Laughon, 1994, Price et al., 1993, Grossniklaus et al., 1989, Lehmann et al., 1983)

neu^9L

(Tearle and Nusslein-Volhard, 1987)

neu^IL119

(Li and Baker, 2001)

neur1

(Li and Baker, 2004)

neur¹

(Kalodimou et al., 2023, Arefin et al., 2019, Contreras et al., 2018, Miller and Posakony, 2018, Yamakawa et al., 2018, Bivik et al., 2015, Ulvklo et al., 2012, Cho and Fischer, 2011, Monastirioti et al., 2010, Eun et al., 2008, Pavlopoulos et al., 2008, Commisso and Boulianne, 2007, Terry et al., 2006, Li and Baker, 2004)

neur^9L119

(Babaoglan et al., 2009, Li and Baker, 2004, Kooh et al., 1993, Skeath and Carroll, 1992)

neur^il119

(Vachias et al., 2010)

Name Synonyms

neuralized1

(Commisso and Boulianne, 2007)

Secondary FlyBase IDs

References (38)

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