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General Information
Symbol
Dmel\Brd1
Species
D. melanogaster
Name
FlyBase ID
FBal0001270
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a blood element in the 3' untranslated region, at position +399.

Insertion components
blood{}Brd-1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Bristle multiplication phenotype, ectopic bristles are complete sensory organs. Anterior orbital, ocellar and posterior supra-alar bristle loss due to defects in the cell fate specification in the bristle lineage.

Brd1 homozygotes survive and exhibit more severe phenotypes than heterozygotes. Brd1/+ = Brd1 hemizygous with Brd-. Brd1 strongly affects macrochaetae and other imaginal-disc sensilla (i.e., trichoid, campaniform, basiconic), but only mildly increases microchaete density. In addition to sensillum multiplication, Brd1 homozygotes also exhibit bristle loss, with anterior orbitals absent (>90%) and a less frequent loss of ocellar macrochaetae (<5%).The EMS-induced point revertants of Brd1 tested (Brdrv1 to Brdrv4) are homozygous viable, viable in trans to Brd deficiencies and display no mutant phenotypes in either situation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Brd[+]/Brd1 is an enhancer of visible phenotype of upd11

Brd[+]/Brd1 is an enhancer of visible | dominant phenotype of amosTft

Suppressor of
Statement
Reference

Brd[+]/Brd1 is a suppressor of visible phenotype of upd1GMR.PB

Phenotype Manifest In
Enhanced by
Statement
Reference

Brd1 has phenotype, enhanceable by Dns1

Brd1 has phenotype, enhanceable by DlCS20

Brd1 has phenotype, enhanceable by E(Brd)M101

Brd1 has phenotype, enhanceable by N55e11

Brd1 has phenotype, enhanceable by neur11

Brd1 has phenotype, enhanceable by neur1

Brd1 has phenotype, enhanceable by neurA101

Brd1 has phenotype, enhanceable by neurIP-1

Suppressed by
Statement
Reference

Brd1 has phenotype, suppressible by H21

Enhancer of
Statement
Reference

Brd[+]/Brd1 is an enhancer of eye phenotype of upd11

Brd[+]/Brd1 is an enhancer of macrochaeta | ectopic phenotype of amosTft

Brd1 is an enhancer of phenotype of Dns1

Suppressor of
Statement
Reference

Brd[+]/Brd1 is a suppressor of eye phenotype of upd1GMR.PB

Additional Comments
Genetic Interactions
Statement
Reference

The amosTft/+ phenotype ectopic bristle phenotype is enhanced by Brd1/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (1)
Stocks (1)
Notes on Origin
Discoverer

Groger.

External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (7)