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General Information
Symbol
Dmel\amosTft
Species
D. melanogaster
Name
Tufted
FlyBase ID
FBal0016764
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Tft1, Tft
Key Links
Mutagen
Nature of the Allele
Mutagen
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Duplication and translocation of sequences from 36F3-36F7 to 37A. The proximal limit of the duplication has not been determined, but extends a minimum of 75kb upstream of amos. The distal limit of the duplication terminates in the vicinity of amos but its structure is complex.

Small rearrangement of the amos chromosomal region, most probably a duplication of several kilobases including the amos gene.

Caused by aberration
Carried on aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygotes have many ectopic macrochaetae and microchaetae. Ectopic bristles are particularly seen in the postalar, dorsocentral and scutellar regions of the notum. Tufts of closely spaced or even adjacent bristles are seen. Ectopic bristles are also seen in the anterior-central portion of the scutellum and the metathoracic notum. Ectopic sensory organ precursor cells form in the presumptive posterior notum and scutellum of heterozygous wing discs.

Heterozygotes and homozygotes have extra bristles mainly in the postalar, dorsocentral and scutellar regions of the dorsal mesothorax. Ectopic bristles and other sensory organs are also formed in the metanotum, dorsal to the halteres, in heterozygotes. The extra bristles seen in heterozygotes and homozygotes can develop very close together, forming tufts, and in some cases several tormogens can be fused together. Heterozygotes and homozygotes have a reduced scutellum. The average number of ectopic macrochaetae per heminotum is 23 +/- 3 in heterozygous flies. Ectopic sensory bristles are occasionally seen in the antennae of heterozygous flies, while the arrangement of the olfactory sensilla is essentially normal. A large number of extra sensory organ precursor cells (SOPs) form in the presumptive posterior notum in the wing disc in heterozygotes. These extra SOPs form very close together and their appearance is sequential and occurs concomitantly with the normal SOPs. amosTft embryos show an increase in the number of neurons in the dorsal cluster of the peripheral nervous system. Occasionally the dorsal bipolar neuron is duplicated.

Heterozygotes have an increased number of bristles in the postalar (13-18), dorsocentral (5-10) and scutellar (7-10) regions of the thorax (normal numbers are 4-5, 3-4 and 4-5 respectively).

The total number of bristles on the basitarsi of the second legs is slightly increased.

Extra bristles often very close together; underlying neurons make functional contacts with the CNS (Ghysen and Richelle, 1979). Innervated bristles also found in the metanotum, which has no bristles in wild-type flies (Garcia-Bellido and Deak). Dominant mutation characterized by an increased number of bristles in the postalar, dorsocentral and scutellar regions; tufts of bristles formed on mesothorax in both homo- and heterozygotes; bristles shorter in homozygotes. Extra bristles located dorsal to halteres at junction of thorax and abdomen. Posterior part of mesonotum appears wider than normal. Homo- and heterozygous females have a greatly reduced scutellum; scutoscutellar suture almost absent; heterozygous males have a nearly normal scutellum (Arnheim, 1967). Small to moderate amounts of fluid tend to remain between the epithelial layers of the wing. Penetrance of extra-bristle character 100%. amos not suppressed by Df(1)sc19 but suppressed by Df(1)260-1 (Garcia-Bellido, communicated to Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat and Modolell, 1985). Cell autonomous in mosaics (Arnheim, 1967). Viability and fertility low.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

amosTft has visible | dominant phenotype, enhanceable by Brd[+]/Brd1

amosTft has visible | dominant phenotype, enhanceable by DlM1/Dl[+]

amosTft has visible | dominant phenotype, enhanceable by emc1/emc11

Suppressed by
Statement
Reference

amosTft has visible | dominant phenotype, suppressible | partially by da[+]/da10

amosTft has visible | dominant phenotype, suppressible | partially by H2/H[+]

amosTft has visible | dominant phenotype, suppressible | partially by NAx-M1/N[+]

amosTft has visible | dominant phenotype, suppressible by Df(1)ase-1

NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

amosTft has macrochaeta | ectopic phenotype, enhanceable by Brd[+]/Brd1

amosTft has macrochaeta | ectopic phenotype, enhanceable by DlM1/Dl[+]

NOT Enhanced by
Statement
Reference

amosTft has phenotype, non-enhanceable by acT52.2

Suppressed by
Statement
Reference

amosTft has macrochaeta | ectopic phenotype, suppressible | partially by da[+]/da10

amosTft has macrochaeta | ectopic phenotype, suppressible | partially by H2/H[+]

amosTft has macrochaeta | ectopic phenotype, suppressible | partially by NAx-M1/N[+]

NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference

amosTft/amos[+] is an enhancer of eye phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

Suppressor of
Statement
Reference

amosTft is a suppressor of microchaeta | ectopic & scutellum phenotype of h1

Additional Comments
Genetic Interactions
Statement
Reference

The amosTft/+ phenotype ectopic bristle phenotype is enhanced by Brd1/+. amosTft is epistatic to Df(1)sc10-1/Y - Df(1)sc10-1/Y ; amosTft/+ flies have ectopic sensory organs in the regions seen in amosTft/+ animals.

The average number of ectopic macrochaetae per heminotum in amosTft/+ flies is increased to 35 +/- 6 if they are also carrying emc1/emc11. The average number of ectopic macrochaetae per heminotum in amosTft/+ flies is increased to 33 +/- 5 if they are also carrying DlM1/+. The average number of ectopic macrochaetae per heminotum in amosTft/+ flies is reduced to 16 +/- 4 if they are also carrying NAx-M1/+. The average number of ectopic macrochaetae per heminotum in amosTft/+ flies is reduced to 19 +/- 2 if they are also carrying H2/+. The average number of ectopic macrochaetae per heminotum in amosTft/+ flies is reduced to 6 +/- 2 if they are also expressing E(spl)Scer\UAS.cSa under the control of Scer\GAL4C-765. The average number of ectopic macrochaetae per heminotum in amosTft/+ flies is reduced to 4 +/- 2 if they are also carrying emcD/emcD. The ectopic microchaetae seen on the scutellum in h1 flies are suppressed by amosTft. The tufts of ectopic bristles on the notum that are seen in amosTft/+ flies are suppressed by Df(1)ase-1, but are unaffected by Df(1)sc10-1.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (1)
Stocks (36)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)