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General Information
Symbol
Dmel\emcD
Species
D. melanogaster
Name
FlyBase ID
FBal0003710
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Ach, emcAch
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Insertion of a Tirant element within the coding region.

Insertion of 5.7kb Tirant element into emc, adjacent to nucleotide 1106 (G). The insertion truncates the emc open reading frame shortly after the insertion, consequently the emcD protein lacks the 42 carboxy-terminal amino acids of the wild type emc protein.

Insertion components
Tirant{}emcD
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes have slightly smaller wings than normal and lack the distal region of wing vein L5.

Mitotic clones in the wing tend to avoid veins.

Heterozygotes lack anterior-medial microchaetae. emcD reduces ASC transcription.

Absence of specific macrochaetae on the notum and reduction of the total number of microchaetae. emcD corrects Hw phenotypes in both ectopic and normal positions.

Wings have plexi between LII and LIII on one side and between LIV and LV on the other. Terminal gaps of LV, thinner veins and broader than normal wings.

RK1 Heterozygotes lack one or both postvertical bristles and often lack other bristles. Wing vein L5 is often incomplete. Homozygotes exhibit missing postvertical bristles and ocellars are absent or strongly reduced, patches of microchaetae and other bristles are often missing.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

emcD is an enhancer of visible phenotype of vnddd-3/vn1

Suppressor of
Statement
Reference

emcD is a suppressor of visible phenotype of Scer\GAL4bbg-C96, mamH.UAS

emcD/emcD is a suppressor | partially of visible | dominant phenotype of amosTft

emc[+]/emcD is a suppressor of visible | heat sensitive phenotype of HC2.hs

emcD is a suppressor of visible | recessive phenotype of net1

emcD/emcD is a suppressor of visible phenotype of rhoStg/rhoWk

emcD is a suppressor of visible | recessive phenotype of px72

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

emcD has phenotype, enhanceable by NAx-1

emcD has phenotype, enhanceable by NAx-M2

emcD has phenotype, enhanceable by NAx-M3

Suppressed by
Statement
Reference

emcD has phenotype, suppressible by Dlunspecified

Enhancer of
Statement
Reference

emcD is an enhancer of wing vein phenotype of vnddd-3/vn1

emc[+]/emcD is an enhancer of phenotype of sc4

emc[+]/emcD is an enhancer of phenotype of sc260-14

emc[+]/emcD is an enhancer of phenotype of ac3

Suppressor of
Statement
Reference

emcD is a suppressor of wing margin phenotype of Scer\GAL4bbg-C96, mam1

emc[+]/emcD is a suppressor of wing vein | ectopic | heat sensitive phenotype of HC2.hs

emc[+]/emcD is a suppressor of wing | heat sensitive phenotype of HC2.hs

emcD is a suppressor of wing vein | ectopic phenotype of px72

emcD is a suppressor of wing vein | ectopic phenotype of net1

emcD/emcD is a suppressor of wing vein phenotype of EgfrE3

emcD is a suppressor of phenotype of Dlunspecified

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The wing nicking phenotype caused by expression of mamH.Scer\UAS under the control of Scer\GAL4bbg-C96 is suppressed if the flies are also carrying emcD.

The average number of ectopic macrochaetae per heminotum in amosTft/+ flies is reduced to 4 +/- 2 if they are also carrying emcD/emcD.

emcD enhances the loss of wing veins seen in vn1/vnddd-3 flies or Egfrt1/Egfrf37 flies. Egfrt1 homozygotes do not have a wing vein phenotype. Egfrt1 emcD double homozygotes show loss of wing veins. The interactions between emcD and rhove-1/rhove-1 or rhove-1/rho9 are additive. The ectopic wing vein phenotype of EgfrE3/+ flies is slightly suppressed by emcD/emcD. The extra wing vein phenotype of px72 or net1 homozygotes is suppressed by emcD.

emcD has synergistic interactions with H alleles and mutual rescuing with Dl alleles. The NAx-1, NAx-M2 and NAx-M3 alleles exaggerate the emcD phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer

Craymer.

External Crossreferences and Linkouts ( 3 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
Synonyms and Secondary IDs (4)
References (24)