FlyBase Allele Report: Dmel\emc[D]

General Information

Symbol

Dmel\emc^D

Species

D. melanogaster

Name

FlyBase ID

FBal0003710

Feature type

allele

Associated gene

Dmel\emc

Associated Insertion(s)

Tirant{}emc^D

Carried in Construct

Also Known As

Ach, emc^Ach

Key Links

Genomic Maps

JBrowse

Allele class

gain of function allele

neomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

gain of function allele

(Baonza and Garcia-Bellido, 1999, Milan et al., 1997, Cubas and Modolell, 1992, Cubas et al., 1991, de Celis et al., 1991, Garrell and Modolell, 1990, Garcia-Alonso and Garcia-Bellido, 1988)

neomorphic allele - genetic evidence

(Diaz-Benjumea and Garcia-Bellido, 1990)

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

Tirant{}emc^D

Cytology

Polytene chromosomes normal.

Description

Insertion of a Tirant element within the coding region.

(Cubas and Modolell, 1992)

Insertion of 5.7kb Tirant element into emc, adjacent to nucleotide 1106 (G). The insertion truncates the emc open reading frame shortly after the insertion, consequently the emc^D protein lacks the 42 carboxy-terminal amino acids of the wild type emc protein.

(Garrell and Modolell, 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:750,132..750,132

(Li and Baker, 2019, Cubas and Modolell, 1992, Lindsley and Zimm, 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(de Celis et al., 1995, Craymer, 1980)

visible | dominant

(Cubas et al., 1991, Craymer, 1980)

visible | recessive

(Baonza and Garcia-Bellido, 1999)

Phenotype Manifest In

(Craymer, 1980)

(Craymer, 1980)

(Craymer, 1980)

(Craymer, 1980)

(Baonza and Garcia-Bellido, 1999)

wing vein L5

(Baonza and Garcia-Bellido, 1999, Craymer, 1980)

Detailed Description

Statement

Reference

Homozygotes have slightly smaller wings than normal and lack the distal region of wing vein L5.

(Baonza and Garcia-Bellido, 1999)

Mitotic clones in the wing tend to avoid veins.

(de Celis et al., 1995)

Heterozygotes lack anterior-medial microchaetae. emc^D reduces ASC transcription.

(Mari-Beffa et al., 1991)

Absence of specific macrochaetae on the notum and reduction of the total number of microchaetae. emc^D corrects Hw phenotypes in both ectopic and normal positions.

(de Celis et al., 1991)

Wings have plexi between LII and LIII on one side and between LIV and LV on the other. Terminal gaps of LV, thinner veins and broader than normal wings.

(Diaz-Benjumea and Garcia-Bellido, 1990)

Dominant.

(Garrell and Modolell, 1990)

RK1 Heterozygotes lack one or both postvertical bristles and often lack other bristles. Wing vein L5 is often incomplete. Homozygotes exhibit missing postvertical bristles and ocellars are absent or strongly reduced, patches of microchaetae and other bristles are often missing.

(Craymer, 1980)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

emc^D is an enhancer of visible phenotype of Egfr^f37/Egfr^t1

(Baonza and Garcia-Bellido, 1999)

emc^D is an enhancer of visible phenotype of vn^ddd-3/vn¹

(Baonza and Garcia-Bellido, 1999)

Suppressor of

Statement

Reference

emc^D is a suppressor of visible phenotype of Scer\GAL4^bbg-C96, mam^H.UAS

(Kwon et al., 2013)

emc^D/emc^D is a suppressor of visible | dominant phenotype of amos^Tft

(Villa-Cuesta et al., 2003)

emc[+]/emc^D is a suppressor of visible | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

emc^D/emc^D is a suppressor of visible phenotype of rho^Stg/rho^Wk

(Baonza and Garcia-Bellido, 1999)

emc^D is a suppressor of visible | recessive phenotype of net¹

(Baonza and Garcia-Bellido, 1999)

emc^D is a suppressor of visible | recessive phenotype of px⁷²

(Baonza and Garcia-Bellido, 1999)

emc^D/emc^D is a suppressor of visible | recessive phenotype of Egfr^E3

(Baonza and Garcia-Bellido, 1999)

Other

Statement

Reference

Egfr^t1, emc^D has visible | recessive phenotype

(Baonza and Garcia-Bellido, 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

emc^D has phenotype, enhanceable by N^Ax-1

(Mari-Beffa et al., 1991)

emc^D has phenotype, enhanceable by N^Ax-M2

(Mari-Beffa et al., 1991)

emc^D has phenotype, enhanceable by N^Ax-M3

(Mari-Beffa et al., 1991)

Suppressed by

Statement

Reference

emc^D has phenotype, suppressible by Delta^unspecified

(Mari-Beffa et al., 1991)

Enhancer of

Statement

Reference

emc^D is an enhancer of wing vein phenotype of Egfr^f37/Egfr^t1

(Baonza and Garcia-Bellido, 1999)

emc^D is an enhancer of wing vein phenotype of vn^ddd-3/vn¹

(Baonza and Garcia-Bellido, 1999)

emc[+]/emc^D is an enhancer of phenotype of sc⁴

(Mari-Beffa et al., 1991)

emc[+]/emc^D is an enhancer of phenotype of sc^260-14

(Mari-Beffa et al., 1991)

emc[+]/emc^D is an enhancer of phenotype of ac³

(Mari-Beffa et al., 1991)

Suppressor of

Statement

Reference

emc^D is a suppressor of wing margin phenotype of Scer\GAL4^bbg-C96, mam¹

(Kwon et al., 2013)

emc^D/emc^D is a suppressor of macrochaeta | ectopic phenotype of amos^Tft

(Villa-Cuesta et al., 2003)

emc[+]/emc^D is a suppressor of wing vein | ectopic | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

emc[+]/emc^D is a suppressor of wing | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

emc^D/emc^D is a suppressor of wing vein | ectopic phenotype of rho^Stg/rho^Wk

(Baonza and Garcia-Bellido, 1999)

emc^D is a suppressor of wing vein | ectopic phenotype of net¹

(Baonza and Garcia-Bellido, 1999)

emc^D is a suppressor of wing vein | ectopic phenotype of px⁷²

(Baonza and Garcia-Bellido, 1999)

emc^D/emc^D is a suppressor of wing vein phenotype of Egfr^E3

(Baonza and Garcia-Bellido, 1999)

emc^D is a suppressor of phenotype of Delta^unspecified

(Mari-Beffa et al., 1991)

Other

Statement

Reference

Egfr^t1, emc^D has wing vein phenotype

(Baonza and Garcia-Bellido, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The wing nicking phenotype caused by expression of mam^H.Scer\UAS under the control of Scer\GAL4^bbg-C96 is suppressed if the flies are also carrying emc^D.

(Kwon et al., 2013)

The average number of ectopic macrochaetae per heminotum in amos^Tft/+ flies is reduced to 4 +/- 2 if they are also carrying emc^D/emc^D.

(Villa-Cuesta et al., 2003)

emc^D enhances the loss of wing veins seen in vn¹/vn^ddd-3 flies or Egfr^t1/Egfr^f37 flies. Egfr^t1 homozygotes do not have a wing vein phenotype. Egfr^t1 emc^D double homozygotes show loss of wing veins. The interactions between emc^D and rho^ve-1/rho^ve-1 or rho^ve-1/rho⁹ are additive. The ectopic wing vein phenotype of Egfr^E3/+ flies is slightly suppressed by emc^D/emc^D. The extra wing vein phenotype of px⁷² or net¹ homozygotes is suppressed by emc^D.

(Baonza and Garcia-Bellido, 1999)

emc^D has synergistic interactions with H alleles and mutual rescuing with Dl alleles. The N^Ax-1, N^Ax-M2 and N^Ax-M3 alleles exaggerate the emc^D phenotype.

(Mari-Beffa et al., 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

1189

emc^D st¹ in¹ kni^ri-1 p^p Dr^Mio/TM6C, ca¹

Kyoto

106177

emc^D rho^ve-1 rs² st¹ bul^D/TM1

106240

emc^D st¹ in¹ kni^ri-1 p^p Dr^Mio/TM6C, ca¹

Notes on Origin

Discoverer

Craymer.

External Crossreferences and Linkouts ( 3 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAA28933

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ach

(Campuzano, 2001, Ghysen et al., 1993, Riddiford, 1993, Cubas and Modolell, 1992, de Celis et al., 1991, Mari-Beffa et al., 1991, Garrell and Modolell, 1990, Garcia-Alonso and Garcia-Bellido, 1988)

emc^Ach

(Villa-Cuesta et al., 2003, Baonza et al., 2000, Baonza and Garcia-Bellido, 1999, Milan et al., 1997, Nellesen and Posakony, 1996, de Celis et al., 1995)

emc^D

(Li and Baker, 2019, Kwon et al., 2013, Wong et al., 2005)

Name Synonyms

Achaetous

(Campuzano, 2001, Garrell and Campuzano, 1991)

Secondary FlyBase IDs

References (24)

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