FlyBase Allele Report: Dmel\Egfr[E3]

General Information

Symbol

Dmel\Egfr^E3

Species

D. melanogaster

Name

FlyBase ID

FBal0003528

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

Also Known As

Elp^B1, Egfr^ElpB1, DER^elpB1, Egfr^EB1

Key Links

Genomic Maps

JBrowse

Allele class

hypermorphic allele - genetic evidence

gain of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

gain of function allele

(Weber et al., 2003, Stemerdink and Jacobs, 1997, Brunner et al., 1994)

hypermorphic allele - genetic evidence

(Mardon et al., 1994, Xu and Rubin, 1993, Baker et al., 1992)

Mutagen

ethyl methanesulfonate

(Baker and Rubin, 1989)

Progenitor genotype

Cytology

Description

Amino acid replacement: W15R. Amino acid replacement: L24V. Amino acid replacement: A887T. Figure 1 and the text concerning this allele are at odds - the text is correct (note from N. Baker).

(Lesokhin et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:21,523,131..21,523,131 [+]

Nucleotide change:

T21523131C

Reported nucleotide change:

T43C

Amino acid change:

W15R | Egfr-PA

Reported amino acid change:

W15R

Comment:

One of three nucleotide substitutions affecting the amino acid sequence in the Egfr^E3 mutant relative to the reference sequence.

(Lesokhin et al., 1999)

point_mutation

2R:21,557,607..21,557,607 [+]

Nucleotide change:

G21557607A

Reported nucleotide change:

G3165A

Amino acid change:

A887T | Egfr-PA; A936T | Egfr-PB

Reported amino acid change:

A887T

Comment:

One of three nucleotide substitutions affecting the amino acid sequence in the Egfr^E3 mutant relative to the reference sequence.

(Lesokhin et al., 1999)

point_mutation

2R:21,523,158..21,523,158 [+]

Nucleotide change:

C21523158G

Reported nucleotide change:

C70G

Amino acid change:

L24V | Egfr-PA

Reported amino acid change:

L24V

Comment:

One of three nucleotide substitutions affecting the amino acid sequence in the Egfr^E3 mutant relative to the reference sequence.

(Lesokhin et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

axon

(Baker and Rubin, 1992)

crossvein | increased number

(Weber et al., 2003)

crossvein | increased number (with Df(3L)Ar14-8)

(Weber et al., 2003)

crossvein | increased number (with Egfr^t1)

(Weber et al., 2003)

eye

(Herr et al., 2010, Weber et al., 2003, Bai et al., 2001, Ciapponi et al., 2001, Luschnig et al., 2000, Brunner et al., 1994, Freeman, 1994, Mardon et al., 1994, Baker and Rubin, 1992, Baker et al., 1992, Zak and Shilo, 1992)

eye (with Egfr^E1)

(Lesokhin et al., 1999)

eye disc

(Baker et al., 1992)

eye disc | larval stage

(Baker and Yu, 2001)

eye disc | larval stage, with Egfr^1.UAS, Scer\GAL4^GMR.PF

(Baker and Yu, 2001)

eye photoreceptor cell

(Weber et al., 2003, Lim et al., 1997)

macrochaeta

(Diaz-Benjumea and Hafen, 1994)

midline glial cell

(Stemerdink and Jacobs, 1997)

ommatidium

(Baker and Yu, 2001, Luschnig et al., 2000, Baker and Zitron, 1995, Freeman, 1994, Kunes et al., 1993, Baker and Rubin, 1992, Baker et al., 1992, Baker and Rubin, 1989)

photoreceptor neuron

(Baker and Rubin, 1992)

wing

(Luschnig et al., 2000, Kockel et al., 1997, Baker and Rubin, 1992)

wing (with Egfr^E1)

(Lesokhin et al., 1999)

wing | ectopic

(Ciapponi et al., 2001)

wing vein

(Diaz-Benjumea and Hafen, 1994, Baker and Rubin, 1992, Baker and Rubin, 1989)

wing vein | ectopic

(Vaccari et al., 2009, Friedman and Perrimon, 2006, Morey et al., 2001, Luschnig et al., 2000, Brunner et al., 1994, Diaz-Benjumea and Hafen, 1994)

wing vein | ectopic (with Egfr^E1)

(Lesokhin et al., 1999)

wing vein | increased number

(Bai et al., 2001)

wing vein L2

(Angulo et al., 2004)

Detailed Description

Statement

Reference

Egfr^E3/+ produces a small rough eye phenotype compared with wild-type.

(Herr et al., 2010)

Adult wings carrying Egfr^E3 mutations exhibit extra wing veins.

(Vaccari et al., 2009)

Egfr^E3/+ adults have extra vein tissue at the distal end of L2.

(Angulo et al., 2004)

Egfr^E3/+ mutants have eyes that are reduced in size with fewer photoreceptors than wild type. Additionally these mutants have, on average, more than two extra crossveins at the tip of L2 in the wing. Egfr^E3/Egfr^t1 transheterozygotes show a less severe wing phenotype, with the majority of flies exhibiting either no, or one extra crossvein. This phenotype is reduced further in Egfr^E3/Egfr^top-18A transheterozygotes, with the vast majority of flies showing no extra crossveins. Flies that are Egfr^E3/+ and also carry the deficiency Df(3L)Ar14-8 have a slightly reduced wing phenotype, with a quarter of flies exhibiting no extra crossveins, while a quarter of these flies still exhibit more than two extra crossveins in the wing.

(Weber et al., 2003)

Eye of Egfr^E3/+ heterozygotes is rough. Extra wing veins form.

(Bai et al., 2001)

Few ommatidia are seen in homozygous eye discs, in a background of G2-arrested cells. Some mitotic cells are seen adjacent to differentiating ommatidia. Apoptotic cells are seen in columns 7-15 of the developing eye disc.

(Baker and Yu, 2001)

Mutant flies develop wing with ectopic wing material. Egfr^E3 dominantly causes an abnormal eye phenotype. The eye is rough lacking the occasional outer photoreceptor.

(Ciapponi et al., 2001)

Heterozygous mutant wings have ectopic wing vein material.

(Morey et al., 2001)

Heterozygous mutants do not cause any defects in the ocellar sensory system (OSS) neurogenesis or axon guidance.

(Garcia-Alonso et al., 2000)

Heterozygous flies have rough eyes and show a slight overproduction of wing vein material. The eyes of homozygotes are severely reduced in size and contain very few ommatidia. Homozygotes are poorly viable.

(Luschnig et al., 2000)

Heterozygotes occasionally lack some outer photoreceptor cells. This phenotype is not significantly altered if the flies are also homozygous for Dsor1^Su1 or Dsor1^Su7.

(Lim et al., 1997)

Homozygous embryos have slightly more midline glia cells than normal, at least until stage 15. Homozygous first instar larvae have a normal number of midline glia.

(Stemerdink and Jacobs, 1997)

Homozygous flies have a few, widely separated ommatidia. Each ommatidium contains a single R8 cell, as in wild-type flies, and this phenotype is not altered in sca^WB1/sca^OB7 Egfr^E3/Egfr^E1 double homozygotes.

(Baker and Zitron, 1995)

Extra wing veins close to the wing margin.

(Brunner et al., 1994)

Clonal analysis reveals phenotypes in the adult including loss of wing vein, ectopic wing vein, reduced cell size, extra bristles, cell lethality and tergite bristle abnormalities. Phenotype is cell autonomous. rl¹/Df(2R)rl10a suppresses the wing phenotype of Egfr^E3.

(Diaz-Benjumea and Hafen, 1994)

Rough eye phenotype, which is characterised by disorganised ommatidia and reduction in the size of the eye.

(Freeman, 1994)

Eyes are reduced and roughened.

(Mardon et al., 1994)

Eyes contain only 10% of normal ommatidial complement. This is first evident in the imaginal disc where areas of ommatidia are separated by large distances creating completely isolated groups of ommatidia. Axons from these isolated photoreceptor clusters with no near neighbours can project to the larval brain via the optic stalk.

(Kunes et al., 1993)

Homozygous clones in the eye disc are rescued by surrounding heterozygous or wild type cells.

(Xu and Rubin, 1993)

Homozygous eye discs have fewer ommatidia than wild-type. Outgrowth of photoreceptor axons is disturbed, occurring in many directions. Cell death is abundant in the region approximately corresponding to columns 10-15 in wild-type. The pattern of cell division in the eye disc is altered. In the adult eye the ommatidia are separated by numerous pigment cells and mechanosensory bristles. Wing veins show thickening and plexus formation. The eye and wing phenotype is more extreme in the homozygote than the heterozygote.

(Baker and Rubin, 1992)

A morphogenetic furrow crosses the eye disc in homozygotes, but very few ommatidia form. Adults have smaller eyes than normal, with a small number of ommatidia, many of which have the normal cellular constitution. Ommatidia are separated by pigment cells and bristle organs.

(Baker et al., 1992)

The array of ommatidia is less regular in heterozygotes than in wild-type flies, and there is a slight disturbance in the wing vein pattern. Homozygotes have much smaller eyes than normal, containing many fewer ommatidia, and some regions lack ommatidia entirely. These regions contain cells resembling the pigment cells that normally surround each ommatidium, and also mechanosensory bristles. Most ommatidia contain the normal number and arrangement of cells.

(Baker and Rubin, 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Egfr^E3 has visible | dominant phenotype, enhanceable by geminin[+]/geminin^k03202b

(Herr et al., 2010)

Egfr^E3 has visible | dominant phenotype, enhanceable by Gap1[+]/RasGAP1^B2

(Bai et al., 2001)

Egfr^E3 has visible | dominant phenotype, enhanceable by ed[+]/ed^lF20

(Bai et al., 2001)

Egfr^E3 has visible | dominant phenotype, enhanceable by ed[+]/ed^1X5

(Bai et al., 2001)

Egfr^E3 has visible | recessive phenotype, enhanceable by emc¹/emc¹¹

(Baonza and Garcia-Bellido, 1999)

Egfr^E3/Egfr^E1 has visible phenotype, enhanceable by aos^W11

(Lesokhin et al., 1999)

Suppressed by

Statement

Reference

Egfr^E3 has visible | dominant phenotype, suppressible by brm^K804R.Tag:HA/brm[+]

(Herr et al., 2010)

Egfr^E3 has visible | dominant phenotype, suppressible by brm[+]/brm²

(Herr et al., 2010)

Egfr^E3 has visible phenotype, suppressible by Ppm1^UAS.Tag:HA/Scer\GAL4^Bx-MS1096

(Friedman and Perrimon, 2006)

Egfr^E3 has visible | dominant phenotype, suppressible by kay²

(Ciapponi et al., 2001)

Egfr^E3 has visible | semidominant phenotype, suppressible by Shc^BG/Shc[+]

(Luschnig et al., 2000)

Egfr^E3 has visible | semidominant phenotype, suppressible by Shc^111-40/Shc[+]

(Luschnig et al., 2000)

Egfr^E3 has visible | recessive phenotype, suppressible by emc^D/emc^D

(Baonza and Garcia-Bellido, 1999)

Egfr^E3/Egfr^E1 has visible phenotype, suppressible by aos^W11

(Lesokhin et al., 1999)

Egfr^E3/Egfr^E1 has visible phenotype, suppressible by N^l1N-ts1

(Lesokhin et al., 1999)

NOT suppressed by

Statement

Reference

Egfr^E3 has visible phenotype, non-suppressible by Ppm1^{D228A.UAS.Tag:HA}/Scer\GAL4^Bx-MS1096

(Friedman and Perrimon, 2006)

Egfr^E3 has increased cell death | larval stage phenotype, non-suppressible by Hsap\CDKN1A^GMR.PH

(Baker and Yu, 2001)

Egfr^E3 has visible | dominant phenotype, non-suppressible by kay^hs.PZ/kay²

(Ciapponi et al., 2001)

Enhancer of

Statement

Reference

Egfr^E3/Egfr[+] is an enhancer of visible phenotype of Mkp3¹/Mkp3²

(Rintelen et al., 2003)

Suppressor of

Statement

Reference

Egfr^E3/Egfr[+] is a suppressor of visible phenotype of CycE^JP

(Brumby et al., 2004)

Other

Statement

Reference

Egfr^E3, Shc^BG has viable phenotype

(Luschnig et al., 2000)

Egfr^E3, Shc^111-40 has viable phenotype

(Luschnig et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

Egfr^E3 has eye phenotype, enhanceable by geminin[+]/geminin^k03202b

(Herr et al., 2010)

Egfr^E3 has wing vein phenotype, enhanceable by ash2^S112411/ash2^S112411

(Angulo et al., 2004)

Egfr^E3 has wing phenotype, enhanceable by ash2^S112411/ash2^S112411

(Angulo et al., 2004)

Egfr^E3 has wing vein | increased number phenotype, enhanceable by ed[+]/ed^1X5

(Bai et al., 2001)

Egfr^E3 has eye phenotype, enhanceable by Gap1[+]/RasGAP1^B2

(Bai et al., 2001)

Egfr^E3 has eye phenotype, enhanceable by ed[+]/ed^lF20

(Bai et al., 2001)

Egfr^E3 has eye phenotype, enhanceable by ed[+]/ed^1X5

(Bai et al., 2001)

Egfr^E3 has wing vein phenotype, enhanceable by emc¹/emc¹¹

(Baonza and Garcia-Bellido, 1999)

Egfr^E3/Egfr^E1 has wing phenotype, enhanceable by aos^W11

(Lesokhin et al., 1999)

Egfr^E3/Egfr^E1 has wing vein | ectopic phenotype, enhanceable by aos^W11

(Lesokhin et al., 1999)

Egfr^E3 has wing vein phenotype, enhanceable by ed^1X5

(Hsu et al., 1998)

Egfr^E3 has wing vein | ectopic phenotype, enhanceable by rl^Sem

(Brunner et al., 1994)

Egfr^E3 has eye phenotype, enhanceable by rl[+]/rl^Sem

(Brunner et al., 1994)

Egfr^E3 has phenotype, enhanceable by net^unspecified/net^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^E3 has phenotype, enhanceable by px^unspecified/px^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Suppressed by

Statement

Reference

Egfr^E3 has eye phenotype, suppressible by brm^K804R.Tag:HA/brm[+]

(Herr et al., 2010)

Egfr^E3 has eye phenotype, suppressible by brm[+]/brm²

(Herr et al., 2010)

Egfr^E3 has wing vein | ectopic phenotype, suppressible by Ppm1^UAS.Tag:HA/Scer\GAL4^Bx-MS1096

(Friedman and Perrimon, 2006)

Egfr^E3 has crossvein | increased number phenotype, suppressible by Pcyt1¹⁶⁹¹⁹/Cct1[+]

(Weber et al., 2003)

Egfr^E3 has crossvein | increased number phenotype, suppressible by Scer\GAL4^sd-SG29.1/Pcyt1^Ala.UAS

(Weber et al., 2003)

Egfr^E3 has crossvein | increased number phenotype, suppressible by Cct1[+]/Pcyt1^EP831

(Weber et al., 2003)

Egfr^E3 has eye photoreceptor cell phenotype, suppressible by Pcyt1¹⁶⁹¹⁹/Cct1[+]

(Weber et al., 2003)

Egfr^E3 has eye phenotype, suppressible by kay²

(Ciapponi et al., 2001)

Egfr^E3 has wing | ectopic phenotype, suppressible by kay¹

(Ciapponi et al., 2001)

Egfr^E3 has wing | ectopic phenotype, suppressible by kay²

(Ciapponi et al., 2001)

Egfr^E3 has wing | ectopic phenotype, suppressible by Scer\GAL4^32B/kay^Fbz.UAS

(Ciapponi et al., 2001)

Egfr^E3 has wing vein | ectopic phenotype, suppressible by Sps1^k11320

(Morey et al., 2001)

Egfr^E3 has eye phenotype, suppressible by Shc^BG/Shc[+]

(Luschnig et al., 2000)

Egfr^E3 has wing phenotype, suppressible by Shc^BG/Shc[+]

(Luschnig et al., 2000)

Egfr^E3 has eye phenotype, suppressible by Shc^111-40/Shc[+]

(Luschnig et al., 2000)

Egfr^E3 has wing phenotype, suppressible by Shc^111-40/Shc[+]

(Luschnig et al., 2000)

Egfr^E3 has wing vein phenotype, suppressible by emc^D/emc^D

(Baonza and Garcia-Bellido, 1999)

Egfr^E3/Egfr^E1 has eye phenotype, suppressible by aos^W11

(Lesokhin et al., 1999)

Egfr^E3/Egfr^E1 has eye phenotype, suppressible by N^l1N-ts1

(Lesokhin et al., 1999)

Egfr^E3 has wing phenotype, suppressible by Jra¹

(Kockel et al., 1997)

Egfr^E3 has wing phenotype, suppressible by Jra^IA109

(Kockel et al., 1997)

Egfr^E3 has phenotype, suppressible by spi¹

(Freeman, 1994)

Egfr^E3 has phenotype, suppressible by dac^P

(Mardon et al., 1994)

Egfr^E3 has phenotype, suppressible by rho^unspecified/rho^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^E3 has phenotype, suppressible by kni^unspecified/kni^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^E3 has phenotype, suppressible by H²/H[+]

(Diaz-Benjumea and Garcia-Bellido, 1990)

NOT suppressed by

Statement

Reference

Egfr^E3 has wing vein | ectopic phenotype, non-suppressible by Ppm1^{D228A.UAS.Tag:HA}/Scer\GAL4^Bx-MS1096

(Friedman and Perrimon, 2006)

Egfr^E3 has eye disc | larval stage phenotype, non-suppressible by Hsap\CDKN1A^GMR.PH

(Baker and Yu, 2001)

Egfr^E3 has eye phenotype, non-suppressible by kay^hs.PZ/kay²

(Ciapponi et al., 2001)

Egfr^E3 has wing | ectopic phenotype, non-suppressible by kay^hs.PZ/kay²

(Ciapponi et al., 2001)

Enhancer of

Statement

Reference

Egfr^E3/Egfr[+] is an enhancer of wing phenotype of ash2^S112411

(Angulo et al., 2004)

Egfr^E3/Egfr[+] is an enhancer of wing vein | ectopic phenotype of ash2^S112411

(Angulo et al., 2004)

Egfr^E3/Egfr[+] is an enhancer of wing vein | increased number phenotype of Mkp3¹/Mkp3²

(Rintelen et al., 2003)

Egfr^E3/Egfr[+] is an enhancer of wing phenotype of N^55e11

(Weber et al., 2003)

Egfr^E3/Egfr^E3 is an enhancer of phenotype of net^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^E3/Egfr^E3 is an enhancer of phenotype of px¹

(Diaz-Benjumea and Garcia-Bellido, 1990)

NOT Enhancer of

Statement

Reference

Egfr^E3/Egfr[+] is a non-enhancer of axon & ocellus sensory structure phenotype of Scer\GAL4^sca-537.4, htl^DN.UAS.cMb

(Garcia-Alonso et al., 2000)

Egfr^E3 is a non-enhancer of wing disc phenotype of ft^k07918

(Garoia et al., 2000)

Suppressor of

Statement

Reference

Egfr^E3/Egfr[+] is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

Egfr^E3 is a suppressor of axon & ocellus sensory structure | conditional ts phenotype of Nrg^l10

(Garcia-Alonso et al., 2000)

Egfr^E3 is a suppressor of axon & mechanosensory neuron & adult head | conditional ts phenotype of Nrg^l10

(Garcia-Alonso et al., 2000)

Egfr^E3 is a suppressor of phenotype of vn^L6

(Schnepp et al., 1996)

Egfr^E3 is a suppressor of phenotype of vn^ddd-13

(Schnepp et al., 1996)

Egfr^E3/Egfr^E3 is a suppressor | partially of wing vein phenotype of rho^unspecified, vn^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^E3/Egfr[+] is a suppressor of phenotype of H²

(Diaz-Benjumea and Garcia-Bellido, 1990)

Egfr^E3/Egfr[+] is a suppressor of phenotype of kni^unspecified

(Diaz-Benjumea and Garcia-Bellido, 1990)

NOT Suppressor of

Statement

Reference

Egfr^E3/Egfr[+] is a non-suppressor of axon & mechanosensory neuron & adult head phenotype of Scer\GAL4^sca-537.4, htl^DN.UAS.cMb

(Garcia-Alonso et al., 2000)

Egfr^E3 is a non-suppressor of wing disc phenotype of ft^k07918

(Garoia et al., 2000)

Other

Statement

Reference

Egfr^E3, stg^hs.PE3 has eye-antennal disc phenotype

(Kylsten and Saint, 1997)

Egfr^E3, stg^hs.PE3 has wing disc phenotype

(Kylsten and Saint, 1997)

Egfr^E3, dac⁸ has eye phenotype

(Mardon et al., 1994)

Egfr^E3, dac⁹ has eye phenotype

(Mardon et al., 1994)

Egfr^E3, dac² has eye phenotype

(Mardon et al., 1994)

Egfr^E3, dac⁵ has eye phenotype

(Mardon et al., 1994)

Egfr^E3, dac⁶ has eye phenotype

(Mardon et al., 1994)

Egfr^E3, dac⁷ has eye phenotype

(Mardon et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

The small rough eye phenotype of Egfr^E3/+ is suppressed by expression of the brm^{K804R.T:Ivir\HA1} genomic construct.

The small rough eye phenotype of Egfr^E3/+ is suppressed by brm²/+.

geminin^k03202b/+ enhances the Egfr^E3/+ small rough eye phenotype.

(Herr et al., 2010)

Egfr^E3/+ adults have extra vein tissue at the distal end of L2. This phenotype is enhanced by ash2^S112411/ash2^S112411 - the resulting wings are more reduced and have more ectopic veination than ash2^S112411/ash2^S112411 animals.

(Angulo et al., 2004)

Egfr^E3/+, Cct1¹⁶⁹¹⁹/+ double mutants show reduced loss of photoreceptors in the eye compared to Egfr^E3/+ single mutants. Additionally, the eyes of the double mutants show a more regular arrangement of ommatidia. The extra crossvein phenotype seen in the wings of Egfr^E3/+ flies is partially suppressed in Cct1^EP831/+, Egfr^E3/+ double mutants, with the majority of these flies exhibiting two, rather than several, extra crossveins. This phenotype is further suppressed in Cct1¹⁶⁹¹⁹/+, Egfr^E3/+ double mutants, with the majority of these flies exhibiting no, or only one, extra crossvein in the wing. Further, the expression of Cct1^Ala.Scer\UAS under the control of Scer\GAL4^sd-SG29.1 also partially suppresses the Egfr^E3 wing phenotype. The Egfr^E3 allele dominantly enhances the notched wing phenotype seen in N^55e11/+ flies.

(Weber et al., 2003)

The number of ommatidia in the eyes of Egfr^E1/Egfr^E3 adults is not altered if the flies are also expressing BacA\p35^GMR.PH, but the number of pigment cells is increased in these animals.

(Yu et al., 2002)

The addition of SelD^k11320/+ to Egfr^E3/+ animals leads to a complete suppression of the ectopic wing phenotype in 66% of wings and a partial suppression in the rest.

(Morey et al., 2001)

Heterozygous mutants do not cause any defects in the ocellar sensory system (OSS) neurogenesis or axon guidance.

(Garcia-Alonso et al., 2000)

The eye and wing phenotypes are dominantly suppressed by Shc^BG or Shc^111-40. The Egfr^E3 phenotype is completely suppressed if the flies are also homozygous for Shc^BG or Shc^111-40 and the viability of these flies is restored.

(Luschnig et al., 2000)

Null alleles of ru interact dominantly with Egfr^E3.

(Wasserman et al., 2000)

The ectopic wing vein phenotype of Egfr^E3/+ flies is slightly enhanced by emc¹/emc¹¹ and slightly suppressed by emc^D/emc^D.

(Baonza and Garcia-Bellido, 1999)

argos^W11 enhances the extra wing vein phenotype of Egfr^E1/Egfr^E3 transheterozygotes but suppresses the eye phenotype. N^l1N-ts1 also suppresses the eye phenotype of Egfr^E1/Egfr^E3.

(Lesokhin et al., 1999)

Appearance of ectopic wing tissue in the adult wing is suppressed by loss of a functional copy of Jra (Jra¹ or Jra^IA109).

(Kockel et al., 1997)

25 minutes of heat induced stg^hs.PE3 expression causes mitotic cell appearance in the eye and wing discs. Induction of mitosis in the eye discs leads to a marked reduction of pyknotic bodies that were normally present on the basal side of the discs. Cellular progression into and through apoptosis is disrupted by ectopic stg expression. Heat induced stg expression does not affect the mutant eye phenotype: adults exhibit small elliptical and rough eyes as seen in Egfr^E3 homozygotes.

(Kylsten and Saint, 1997)

Suppresses the viability of vn^ddd-13, the proliferation defects in vn^L6 and (partially) the small disc phenotype of vn^γ4.

(Schnepp et al., 1996)

The heterozygous extra wing vein phenotype is enhanced when transheterozygous with rl^Sem. Flies heterozygous for Egfr^E3 and rl^Sem have smaller eyes than Egfr^E3 heterozygotes alone.

(Brunner et al., 1994)

Reduction of the dose of spi causes some suppression of the Egfr^E3 phenotype; more ommatidia and increase in the size of the eye. S²¹⁸ Egfr^E3 double heterozygous adults exhibit severely reduced and rough eyes. Most ommatidia have a reduced number of photoreceptor cells, there are also defects in orientation, spacing and pigment cell and bristle numbers. This phenotype is more severe than a simple addition of the dominant effects of Egfr and S. Mutation has no effect on rho^hs.sev rough eye phenotype.

(Freeman, 1994)

Enhances the wing phenotype of Df(1)N-54l9, N^264-39, Dl^9P, and Dl^KX6 mutations, and the eye phenotype of N^spl-1.

(Baker and Rubin, 1992)

Double mutant combinations of Egfr^E3/Egfr^E3 with net^unspecified/net^unspecified or px¹/px¹ have a superadditive phenotype. Egfr^E3/Egfr^E3 shows a negative interaction in combination with either rho^unspecified/rho^unspecified or kni^unspecified/kni^unspecified. Egfr^E3/+ shows a negative interaction in combination with either H²/+ or Vno^unspecified/+. Egfr^E3/Egfr^E3 shows a simple additive phenotype with tt¹/tt¹ and N^Ax-M1/+. Egfr^E3/+ shows a simple additive phenotype with N^55e11/+ and Dl^M1/+. E(spl)^rv1 gro^unspecified Egfr^E3/Egfr^E3 flies show a simple additive phenotype. The lack of vein phenotype of rho^unspecified vn^unspecified flies is partially rescued by Egfr^E3/Egfr^E3.

(Diaz-Benjumea and Garcia-Bellido, 1990)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\CDKN1A^GMR.PH in homozygous Egfr^E3 mutants does not prevent the apoptosis of undifferentiated cells in the eye disc that is seen in the Egfr^E3 mutant background.

(Baker and Yu, 2001)

Complementation and Rescue Data

Comments

Expression of Egfr^1.Scer\UAS under the control of Scer\GAL4^GMR.PF in Egfr^E3 flies results in mitosis in all cells in the eye disc. Expression of stg^hs.PE3 using heat shock in Egfr^E3 discs causes all G2-arrested cells to enter mitosis. This mitosis is abnormal, with the cells remaining in mitosis for 4 hours (mitosis normally lasts about 15 minutes). Extensive cell death occurs amongst the mitotically arrested cells from 2-4 hours, so that some of the disc epithelium is lost.

(Baker and Yu, 2001)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Clonal analysis shows that normal ommatidia are less likely to develop if precluster cells R2, R3, R4, R5 or R8 are Egfr^E3/Egfr^E3.

(Baker and Rubin, 1992)

Egfr protein expression in the eye imaginal discs of Egfr^E3 homozygous third instar larvae has been compared with wild-type expression. The pattern of cell divisions posterior to the morphogenetic furrow is altered in Egfr^E3 homozygotes.

(Zak and Shilo, 1992)

No interaction with P{sev-svp1} or P{sev-svp2} exists.

(Begemann et al., 1995)

External Crossreferences and Linkouts ( 5 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

DER^EB1

(Polaczyk et al., 1998)

DER<up>Elp B1</up>

(Kylsten, 1994)

DER^ElpB1

(Schnepp et al., 1996, Brunner et al., 1994)

DER^elpB1

(Rintelen et al., 2003)

EGFR-ElpB1

(Zoranovic et al., 2018)

EGFR^E3

(Zoranovic et al., 2018)

EGFR^ElpB1

(Herr et al., 2010)

Egfr^E3

Egfr^EB1

(Freeman, 1994, Xu and Rubin, 1993)

Egfr^ElpB1

(Mirkovic and Mlodzik, 2006, Weber et al., 2003, Begemann et al., 1995)

Elp^1B

(Schweitzer et al., 1995)

Elp^B1

(Zhu et al., 2017, Almudi et al., 2009, Vaccari et al., 2009, Friedman and Perrimon, 2006, Baonza and Freeman, 2005, Angulo et al., 2004, Brumby et al., 2004, Bai et al., 2001, Baker and Yu, 2001, Ciapponi et al., 2001, Morey et al., 2001, Garcia-Alonso et al., 2000, Luschnig et al., 2000, Wasserman et al., 2000, Bai et al., 1999, Baonza and Garcia-Bellido, 1999, Chen and Chien, 1999, Lesokhin et al., 1999, Hsu et al., 1998, Roch et al., 1998, Jacobs et al., 1997, Kockel et al., 1997, Lim et al., 1997, Stemerdink and Jacobs, 1997, Verheyen et al., 1996, Baker and Zitron, 1995, de Celis and Garcia-Bellido, 1994, Diaz-Benjumea and Hafen, 1994, Mardon et al., 1994, Kunes et al., 1993, Baker and Rubin, 1992, Baker et al., 1992, Zak and Shilo, 1992, Baker et al., 1990, Diaz-Benjumea and Garcia-Bellido, 1990, Baker and Rubin, 1989)

ElpB1

(Herr et al., 2010)

egfr^E3

(Yu et al., 2002)

top^ElpB1

(Garoia et al., 2000)

Name Synonyms

ellipse

(Vaccari et al., 2009)

ellipseB1

(Jones et al., 2006)

Secondary FlyBase IDs

References (54)

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