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Citation
de Celis, J.F., Garcia-Bellido, A. (1994). Roles of the Notch gene in Drosophila wing morphogenesis.  Mech. Dev. 46(2): 109--122.
FlyBase ID
FBrf0074921
Publication Type
Research paper
Abstract

The Notch gene encodes a transmembrane protein that functions as a receptor of intercellular signals in many developmental processes of Drosophila. We study here the Notch function in wing morphogenesis and vein patterning in genetic mosaics of both Notch null and Notch gain-of-function alleles. Cell proliferation and differentiation properties of mutant Notch cells define three different Notch requirements in the wing: in imaginal disc cell proliferation, in restriction of vein differentiation and in margin formation. The study of Notch mosaics in different mutant backgrounds reveals that Notch activity during epidermal cell proliferation and wing vein differentiation is exerted by its regulation of a common group of genes involved in the specification and restriction of vein competent regions.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mech. Dev.
    Title
    Mechanisms of Development
    Publication Year
    1990-
    ISBN/ISSN
    0925-4773
    Data From Reference
    Aberrations (4)
    Alleles (10)
    Genes (6)