FlyBase Allele Report: Dmel\aos[W11]

Only 5% of eggs derived from argos^Δ7/argos^W11 have defects in dorsal appendage morphology, which include a reduced distance between the two appendages and appendages that are shorter than normal.

(Zartman et al., 2009)

Heterozygotes show a direct effect on the shape of the wing.

(Dworkin and Gibson, 2006)

When homozygous mutant clones are made in the eye, although many of the mutant ommatidia have too many photoreceptors, a significant proportion have the correct number. many of these ommatidia are misrotated.

(Brown and Freeman, 2003)

Mutant eye discs show, in addition to the extra R-cell phenotype, severe ommatidial rotation defects, though the initial 45^oC rotation seen in wild-type is less affected.

(Gaengel and Mlodzik, 2003)

argos^Δ7/argos^W11 hypomorphic females lay a significant proportion of eggs with fused dorsal appendages. Larvae hatch from the eggs, with dorsal-ventral pattern unperturbed.

(Wasserman and Freeman, 1998)

The number of midline glia cells is increased to an average of 5.1 +/- 0.2 cells per segment in homozygous embryos.

(Stemerdink and Jacobs, 1997)

Retinal degeneration in aging flies.

(Brunner et al., 1994)

Mutant ommatidia have extra pigment cells.

(Freeman, 1994)

Reduced viability and rough eye phenotype, including blistering in the posterior region of the eye due to a lawn of undifferentiated cells in the pupal eye. Eyes have abnormal rhabdomere morphology and extra outer photoreceptors. Optic lobes are small and disorganised. Many of the mystery cells start differentiating as neurons and never leave the developing ommatidia. Extra cone cells and an abnormally high number of primary pigment cells are found in the pupal eye. Interommatidial bristle precursors are disorganised though the total number appears to be normal.

(Freeman et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

aos[+]/aos^W11 is an enhancer of visible phenotype of Chmp1^GD11219, Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

argos[+]/aos^W11 is an enhancer of visible phenotype of Scer\GAL4^en-e16E, Socs44A^UAS.cRa

(Rawlings et al., 2004)

aos^W11 is an enhancer of visible phenotype of Egfr^E3/Egfr^E1

(Lesokhin et al., 1999)

NOT Enhancer of

Statement

Reference

argos[+], aos^W11, N[+], N^55e11 is a non-enhancer of abnormal planar polarity phenotype of Pcyt1¹⁶⁹¹⁹

(Weber et al., 2003)

Suppressor of

Statement

Reference

aos^W11 is a suppressor of visible phenotype of Egfr^E3/Egfr^E1

(Lesokhin et al., 1999)

Phenotype Manifest In

Enhancer of

Statement

Reference

aos[+]/aos^W11 is an enhancer of wing vein phenotype of Chmp1^GD11219, Scer\GAL4^Bx-MS1096

(Valentine et al., 2014)

argos[+]/aos^W11 is an enhancer of wing vein | ectopic phenotype of Scer\GAL4^en-e16E, Socs44A^UAS.cRa

(Rawlings et al., 2004)

aos^W11 is an enhancer of photoreceptor cell R8 | increased number phenotype of ed^k01102

(Spencer and Cagan, 2003)

aos^W11 is an enhancer of wing phenotype of Egfr^E3/Egfr^E1

(Lesokhin et al., 1999)

aos^W11 is an enhancer of wing vein | ectopic phenotype of Egfr^E3/Egfr^E1

(Lesokhin et al., 1999)

NOT Enhancer of

Statement

Reference

argos[+], aos^W11, N[+], N^55e11 is a non-enhancer of eye photoreceptor cell phenotype of Pcyt1¹⁶⁹¹⁹

(Weber et al., 2003)

argos[+], aos^W11, N[+], N^55e11 is a non-enhancer of ommatidium phenotype of Pcyt1¹⁶⁹¹⁹

(Weber et al., 2003)

Suppressor of

Statement

Reference

aos^W11 is a suppressor of eye phenotype of Egfr^E3/Egfr^E1

(Lesokhin et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The ectopic wing vein phenotype caused by expression of Socs44A^Scer\UAS.cRa under the control of Scer\GAL4^en-e16E is enhanced by argos^W11/+.

(Rawlings et al., 2004)

argos^W11 enhances the ed^k01102 phenotype; the number of ommatidia with multiple R8 cells is increased from 21% to 46% in the double mutant flies.

(Spencer and Cagan, 2003)

The Cct1¹⁶⁹¹⁹ defective eye phenotype is not significantly enhanced in Cct1¹⁶⁹¹⁹/+, argos^W11/+, N^55e11/+ triple heterozygotes.

(Weber et al., 2003)

argos^W11 enhances the extra wing vein phenotype of Egfr^E1/Egfr^E3 transheterozygotes, but suppresses the eye phenotype.

(Lesokhin et al., 1999)

No effect on the faf eye phenotype.

(Huang and Fischer-Vize, 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

aos^Δ7

(Zartman et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

2513

w⁸; P{lwB}aos^W11/TM3, Sb¹

Notes on Origin

Discoverer

Comments

Excision of the P{lwB} insertion reverts the mutant phenotype to wild type.

(Freeman et al., 1992)

argos^W11 chromosome also carries a mutation at chp, chp^W11, that causes strong rhabdomere defects. Mutation can be recombined off the chromosome.

(Brunner et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

W11

(Dworkin et al., 2011, Dworkin and Gibson, 2006)

aos^W11

(Zhu et al., 2017, Lam et al., 2006, Huang and Fischer-Vize, 1996)

aos^w11

(Valentine et al., 2014, Curtis et al., 2013, Weber et al., 2003)

argos^W11

(Salzer et al., 2010, Zartman et al., 2009, Christensen et al., 2008.7.11, Christensen et al., 2008.7.11, Christensen et al., 2008.7.11)

argos^w11

(Rawlings et al., 2004, Stemerdink and Jacobs, 1997, Stemerdink and Jacobs, 1995, Freeman, 1994)

gil^W11

gil^w11

(Brunner et al., 1994)

Name Synonyms

Secondary FlyBase IDs

References (28)

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