FlyBase Allele Report: Dmel\dac[P]

(Chu et al., 2002, Martini et al., 2000, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Spradling et al., 1999, BDGP Project Members, 1994-1999, Mardon et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Ashburner et al., 1999, Spradling et al., 1999)

visible | recessive

(Martini et al., 2000, Mardon et al., 1994)

Phenotype Manifest In

Detailed Description

Statement

Reference

dac^P heterozygotes do not exhibit any size alterations or roughness in eyes when compared to control adults.

(Hoang et al., 2010)

Homozygous adults have a mild mushroom body phenotype. The eyes are consistently (but less severely than ey²) reduced in size.

(Martini et al., 2000)

Eyes of homozygotes are reduced and roughened. 50% of ommatidia have either too many or too few photoreceptors, and the ommatidial array is disrupted. Morphogenetic furrow movement is uneven, resulting in a curved furrow that has advanced further at midline than at the periphery of the disc. While legs have normal proximal and distal morphology, femur, tibia and proximal three tarsi are fused and condensed.

(Mardon et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dac^P has visible phenotype, enhanceable by ey²/ey²

(Martini et al., 2000)

dac^P has visible | recessive phenotype, enhanceable by hh[+]/hh^rJ413

(Mardon et al., 1994)

Enhancer of

Statement

Reference

dac^P/dac^P is an enhancer of visible phenotype of ey²

(Martini et al., 2000)

Suppressor of

Statement

Reference

dac^P/dac[+] is a suppressor | partially of abnormal size | adult stage phenotype of CtBP^GSA396, Scer\GAL4^ey.PU

(Hoang et al., 2010)

dac^P/dac[+] is a suppressor | partially of visible | adult stage phenotype of CtBP^GSA396, Scer\GAL4^ey.PU

(Hoang et al., 2010)

dac^P/dac[+] is a suppressor of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Other

Statement

Reference

Egfr^t1, dac^P has visible phenotype

(Mardon et al., 1994)

Phenotype Manifest In

Enhanced by

Statement

Reference

dac^P has eye phenotype, enhanceable by ey²/ey²

(Martini et al., 2000)

dac^P has eye phenotype, enhanceable by hh[+]/hh^rJ413

(Mardon et al., 1994)

NOT Enhanced by

Statement

Reference

dac^P has phenotype, non-enhanceable by ey[+]/ey^D1Da

(Martini et al., 2000)

dac^P has mushroom body phenotype, non-enhanceable by ey[+]/ey^D1Da

(Martini et al., 2000)

dac^P has phenotype, non-enhanceable by ey[+]/ey^JD

(Martini et al., 2000)

dac^P has mushroom body phenotype, non-enhanceable by ey[+]/ey^JD

(Martini et al., 2000)

dac^P has phenotype, non-enhanceable by ey²/ey²

(Martini et al., 2000)

dac^P has adult mushroom body gamma-lobe phenotype, non-enhanceable by ey²/ey²

(Martini et al., 2000)

dac^P has mushroom body phenotype, non-enhanceable by ey²/ey²

(Martini et al., 2000)

Enhancer of

Statement

Reference

dac^P/dac^P is an enhancer of eye phenotype of ey²

(Martini et al., 2000)

Suppressor of

Statement

Reference

dac^P/dac[+] is a suppressor | partially of eye phenotype of CtBP^GSA396, Scer\GAL4^ey.PU

(Hoang et al., 2010)

dac^P/dac[+] is a suppressor of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

dac^P is a suppressor of phenotype of Egfr^E3

(Mardon et al., 1994)

Other

Statement

Reference

Egfr^t1, dac^P has eye phenotype

(Mardon et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

The eyes of dac^P; ey² double homozygotes are consistently very small or absent.

(Martini et al., 2000)

Suppresses the rough eye phenotype of Egfr^E3. dac^P, Egfr^t1 double homozygotes have a reduced, rough eye phenotype that exceeds that of either mutant alone or the expected additive effects of the two mutants. hh^rJ413 dominantly enhances the recessive eye phenotype of dac^P.

(Mardon et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

12047

P{PZ}dac^P/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

G. Rubin.

Comments

Complements: heix^k11403. Complements: Cyt-c-d^bln1.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

dac^P1

(Akimoto et al., 2005)

dac^P

(Iyer et al., 2016, Hoang et al., 2010)

dac^rK364

(Ashburner et al., 1999.10.12)

l(2)rK364

(Spradling et al., 1999)

l(2)rK364^rK364

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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