FlyBase Allele Report: Dmel\Jra[1]

General Information

Symbol

Dmel\Jra¹

Species

D. melanogaster

Name

FlyBase ID

FBal0063161

Feature type

allele

Associated gene

Dmel\Jra

Associated Insertion(s)

Carried in Construct

Also Known As

jun¹, Djun¹

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Kockel et al., 1997)

Mutagen

ethyl methanesulfonate

(Kockel et al., 1997)

Progenitor genotype

Cytology

Description

Mutation is expected to produce a truncated product that lacks the basic region and leucine zipper.

(Kockel et al., 1997)

Amino acid replacement: F177term.

(Kockel et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

MNV

2R:10,097,796..10,097,797 [+]

Nucleotide change:

TC10097796AA

Amino acid change:

F177term | Jra-PA; F177term | Jra-PB; F177term | Jra-PC

Comment:

Reported as a nonsense mutation at F177 but the nucleotide change was not specified. Has been annotated as a TTC to TAA change.

(Kockel et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates sensory system disease

modeled by ebi^E90, ebi^P7

(Lim et al., 2012)

exacerbates multiple endocrine neoplasia type 1

modeled by Mnn1^UAS.cCa

(Cerrato et al., 2006)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Kockel et al., 1997)

some die during embryonic stage | recessive

(Kockel et al., 1997)

Phenotype Manifest In

embryonic dorsal epidermis

(Kockel et al., 1997)

Detailed Description

Statement

Reference

Jra¹ neuroblast clones in the mushroom body have no gross axonal phenotypes.

(Rallis et al., 2010)

Jra¹/+ flies show no thoracic abnormalities.

(Cerrato et al., 2006)

Mutant embryos die in mid to late embryogenesis with large anterior and dorsal holes in the cuticle. Mitotic clones in the eye cause no abnormal defects in eye development. Microscopic inspection of tangential sections reveals minor defects, the occasional missing photoreceptor.

(Kockel et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Jra¹/Jra[+] is a suppressor of abnormal neuroanatomy | adult stage | progressive phenotype of ebi^1-334.GMR

(Lim et al., 2012)

Jra¹/Jra[+] is a suppressor of abnormal oxidative stress response phenotype of ebi^E90/ebi^P7

(Lim et al., 2012)

Jra¹/Jra[+] is a suppressor of abnormal planar polarity phenotype of dsh^hs.sev.B

(Weber et al., 2008)

Jra¹/Jra[+] is a suppressor of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Jra¹/Jra[+] is a suppressor of visible phenotype of Scer\GAL4^69B, nmo^c5-1.UAS

(Mirkovic et al., 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

Jra¹/Jra[+] is an enhancer of adult thorax phenotype of Mnn1^UAS.cCa, Scer\GAL4^pnr-MD237

(Cerrato et al., 2006)

Suppressor of

Statement

Reference

Jra¹/Jra[+] is a suppressor of eye phenotype of ebi^1-334.GMR

(Lim et al., 2012)

Jra¹/Jra[+] is a suppressor of retina | progressive phenotype of ebi^1-334.GMR

(Lim et al., 2012)

Jra¹/Jra[+] is a suppressor of ommatidium phenotype of dsh^hs.sev.B

(Weber et al., 2008)

Jra¹/Jra[+] is a suppressor of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Jra¹/Jra[+] is a suppressor of posterior crossvein phenotype of Scer\GAL4^69B, nmo^c5-1.UAS

(Mirkovic et al., 2002)

Jra¹/Jra[+] is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^69B, nmo^c5-1.UAS

(Mirkovic et al., 2002)

Jra¹/Jra[+] is a suppressor | partially of ommatidium phenotype of peb¹

(Pickup et al., 2002)

Jra¹ is a suppressor of ommatidium phenotype of Rac1^V12.hs.sev

(Fanto et al., 2000)

Jra¹ is a suppressor of phenotype of dsh^hs.sev.B

(Boutros et al., 1998)

Jra¹ is a suppressor of eye photoreceptor cell | ectopic phenotype of rl^Sem

(Kockel et al., 1997)

Jra¹/Jra[+] is a suppressor of eye photoreceptor cell phenotype of sev^S11.Tag:MYC

(Kockel et al., 1997)

Jra¹ is a suppressor of wing phenotype of Egfr^E3

(Kockel et al., 1997)

NOT Suppressor of

Statement

Reference

Jra¹ is a non-suppressor of phenotype of arm³

(Cox et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Jra¹/+ suppresses the rough eye phenotype seen in flies with two copies of ebi^1-334.GMR.

Jra¹/+ suppresses the late-onset retinal degeneration phenotype of ebi^1-334.GMR/+ flies.

(Lim et al., 2012)

One copy of Jra¹ suppresses the formation of symmetrical ommatidia that is seen in animals expressing dsh^hs.sev.B.

(Weber et al., 2008)

Expression of Mnn1^Scer\UAS.cCa under the control of Scer\GAL4^pnr-MD237 in a Jra¹/+ background results in an enhanced thoracic cleft compared to Mnn1^Scer\UAS.cCa expression in a wild-type background.

(Cerrato et al., 2006)

Heterozygosity for Jra¹ can suppress the wing-vein defects, as well as wing shape and size defects seen in Scer\GAL4^69B, nmo^{c5-1.Scer\UAS} adults.

(Mirkovic et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

FlyBase curator comment: The Jra¹ allele, first referred to as 'jun[1]' by Kockel et al., 1997 (FBrf0095439), is NOT the same as Jra^76-19, first referred to as 'Djun[1]' by Hou et al., 1997 (FBrf0095018). The Materials and Methods section of FBrf0095018 states that their 'Djun[1]' was originally named '76-19' by Bour et al, 1995 (FBrf0079902), and this is the superscript used for this allele in FlyBase.

(FlyBase, 1992-)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Djun¹

(Fanto, 2000, Fanto et al., 2000, McEwen et al., 2000)

Jra1

(Cerrato et al., 2004)

Jra¹

(Lim et al., 2012, Rallis et al., 2010)

Jun¹

(Lim et al., 2012, Rallis et al., 2010)

dJun¹

(Delaney et al., 2006)

jra¹

(Cerrato et al., 2006)

jun¹

(Zhu et al., 2019, Weber et al., 2008, Pickup et al., 2002, Boutros et al., 1998, Kockel et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (17)

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