FlyBase Allele Report: Dmel\emc[11]

General Information

Symbol

Dmel\emc¹¹

Species

D. melanogaster

Name

FlyBase ID

FBal0003688

Feature type

allele

Associated gene

Dmel\emc

Associated Insertion(s)

P{A92}emc¹¹

Carried in Construct

Also Known As

emc^pel

Key Links

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Baonza and Garcia-Bellido, 1999, Garrell and Modolell, 1990)

loss of function allele

(Cubas and Modolell, 1992, de Celis et al., 1991)

Mutagen

X ray

P-element activity

(Heitzler et al., 1996, FlyBase, 1992-)

natural population

(Garcia-Alonso and Garcia-Bellido, 1988)

spontaneous

(Garrell and Modolell, 1990, Romani et al., 1989)

Progenitor genotype

Associated Insertion(s)

P{A92}emc¹¹

Cytology

Polytene chromosomes normal.

Description

P-element insertion near the transcriptional start site.

(Heitzler et al., 1996)

Insertion of a P-element into the promoter region.

(Cubas and Modolell, 1992)

Insertion of P-element, 71bp upstream of the origin of transcription.

(Garrell and Modolell, 1990)

Allele components

Component

Use(s)

Inserted element

P{A92}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage

(de Celis et al., 1991)

some die during embryonic stage

(de Celis et al., 1991)

viable | recessive

(Garrell and Modolell, 1990)

visible | recessive

(Baonza and Garcia-Bellido, 1999)

Phenotype Manifest In

dorsocentral bristle | ectopic

(Usui-Ishihara and Simpson, 2005)

macrochaeta | ectopic

(Mari-Beffa et al., 1991)

microchaeta

(Mari-Beffa et al., 1991)

microchaeta & mesothoracic tergum | supernumerary

(Renaud and Simpson, 2002)

posterior scutellar bristle

(Huang et al., 1995)

sense organ | ectopic

(Skeath and Carroll, 1991)

sensory mother cell

(Huang et al., 1995)

wing

(Baonza and Garcia-Bellido, 1999)

Detailed Description

Statement

Reference

Mutant animals have ectopic dorsocentral bristles, often situated anterior to the wild-type anterior dorsocentral (aDC) bristle. The majority of ectopic macrochaetes anterior to and aligned with the aDC display projection patterns like that of the wild-type aDC.

(Usui-Ishihara and Simpson, 2005)

emc¹¹ animals have a higher density of notal microchaetae, however these bristles still approximately align into rows as seen in wild-type.

(Renaud and Simpson, 2002)

emc¹/emc¹¹ flies have slightly smaller wings than normal, although the wing vein pattern is normal.

(Baonza and Garcia-Bellido, 1999)

The posterior scutellar bristle is displaced from its normal position in homozygous, emc²/emc¹¹ and emc^E12/emc¹¹ flies. Most sensory mother cells emerge earlier in homozygous or emc¹¹/emc² wing discs compared to wild-type, although the precursor of the posterior scutellar bristle appears later than normal. emc^E12/emc¹¹ neur^A101 larvae have very low viability.

(Huang et al., 1995)

emc¹¹/emc^E12 discs show an increased level of sc protein, clusters are similar to wild type though some are slightly enlarged. Strongly labelled nuclei are present scattered over the presumptive notum, they correspond to precursors of ectopic emc bristles.

(Cubas et al., 1991)

Variations in chaetae number and size: ectopic macrochaetae and mesochaetae appear as a second and third posterior row, microchaetae smaller than wild type differentiate posteriorly to the macrochaetae.

(Mari-Beffa et al., 1991)

ac and sc protein patterns are subtly altered in the wing disc. Novel sites of ac and sc expression in the notal region that later coincide with ectopic sensory organs.

(Skeath and Carroll, 1991)

Extra chaetae form in characteristic patterns.

(de Celis et al., 1991)

No modification in the ac/sc patterns of expression in the wing disc.

(Romani et al., 1989)

homozygous viable

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

emc¹/emc¹¹ is an enhancer of visible | dominant phenotype of amos^Tft

(Villa-Cuesta et al., 2003)

emc¹/emc¹¹ is an enhancer of visible | recessive phenotype of Egfr^E3

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is an enhancer of visible | recessive phenotype of bs²

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is an enhancer of visible | recessive phenotype of px⁷²

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is an enhancer of visible phenotype of rho^Stg/rho^Wk

(Baonza and Garcia-Bellido, 1999)

Suppressor of

Statement

Reference

emc¹/emc¹¹ is a suppressor of visible phenotype of Egfr^f37/Egfr^t1

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is a suppressor of visible phenotype of vn^ddd-3/vn¹

(Baonza and Garcia-Bellido, 1999)

Other

Statement

Reference

bs⁰³²⁶⁷, emc¹/emc¹¹ has visible | dominant phenotype

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹, net¹ has visible | dominant phenotype

(Baonza and Garcia-Bellido, 1999)

bs⁰³²⁶⁷, emc¹/emc¹¹ has visible phenotype

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹, net¹ has visible phenotype

(Baonza and Garcia-Bellido, 1999)

Phenotype Manifest In

Enhancer of

Statement

Reference

emc¹/emc¹¹ is an enhancer of macrochaeta | ectopic phenotype of amos^Tft

(Villa-Cuesta et al., 2003)

emc¹/emc¹¹ is an enhancer of wing vein phenotype of Egfr^E3

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is an enhancer of wing vein | ectopic phenotype of bs²

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is an enhancer of wing vein | ectopic phenotype of px⁷²

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is an enhancer of wing vein | ectopic phenotype of rho^Stg/rho^Wk

(Baonza and Garcia-Bellido, 1999)

Suppressor of

Statement

Reference

emc¹/emc¹¹ is a suppressor of wing vein L4 phenotype of Egfr^f37/Egfr^t1

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is a suppressor of wing vein L4 phenotype of vn^ddd-3/vn¹

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is a suppressor | partially of phenotype of sc⁴

(Mari-Beffa et al., 1991)

emc¹/emc¹¹ is a suppressor | partially of phenotype of sc^260-14

(Mari-Beffa et al., 1991)

emc¹/emc¹¹ is a suppressor of phenotype of ac³

(Mari-Beffa et al., 1991)

Other

Statement

Reference

bs⁰³²⁶⁷, emc¹/emc¹¹ has wing vein | ectopic phenotype

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹, px⁷² has wing vein phenotype

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹, net¹ has wing vein | ectopic phenotype

(Baonza and Garcia-Bellido, 1999)

emc¹¹/Df(3L)emc-E12, ac^Hw-49c has dorsal mesothoracic disc & sensory mother cell | ectopic phenotype

(Cubas and Modolell, 1992)

ac^Hw-49c, emc¹¹ has dorsal mesothoracic disc & sensory mother cell | ectopic phenotype

(Cubas and Modolell, 1992)

Additional Comments

Genetic Interactions

Statement

Reference

The average number of ectopic macrochaetae per heminotum in amos^Tft/+ flies is increased to 35 +/- 6 if they are also carrying emc¹/emc¹¹.

(Villa-Cuesta et al., 2003)

emc¹/emc¹¹ suppresses the loss of wing vein L4 seen in vn¹/vn^ddd-3 flies or Egfr^t1/Egfr^f37 flies. The interactions between emc¹/emc¹¹ and rho^ve-1/rho^ve-1 or rho^ve-1/rho⁹ are additive. The ectopic wing vein phenotype of Egfr^E3/+ flies is slightly enhanced by emc¹/emc¹¹. The ectopic wing vein phenotype of rho^Stg/rho^Wk flies is slightly enhanced by emc¹/emc¹¹. The extra wing vein phenotype of px⁷² homozygotes is enhanced by emc¹/emc¹¹. net¹/+ ; emc¹/emc¹¹ flies show an extra wing vein phenotype. The extra wing vein phenotype of bs² homozygotes is enhanced by emc¹/emc¹¹. bs⁰³²⁶⁷/+ ; emc¹/emc¹¹ flies show an extra wing vein phenotype.

(Baonza and Garcia-Bellido, 1999)

ac^Hw-49c/+ ; emc¹¹/Df(3L)emc-E12 wing discs have many ectopic sensory organ mother cells, mostly in the presumptive notum and dorsal wing blade and base.

(Cubas and Modolell, 1992)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

36550

emc¹¹ Diap1^th-1 st¹ cu¹ sr¹ e^s ca¹/TM2

Notes on Origin

Discoverer

Rubio.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Pel

(Skeath and Carroll, 1991)

emc¹¹

emc^Pel

(Renaud and Simpson, 2002)

emc^pel

(Gibert et al., 2005, Usui-Ishihara and Simpson, 2005, Villa-Cuesta et al., 2003, Baonza and Garcia-Bellido, 1999, Heitzler et al., 1996, Huang et al., 1995, Brand et al., 1993, Martinez et al., 1993, Cubas and Modolell, 1992, de Celis et al., 1991, Mari-Beffa et al., 1991, Garrell and Modolell, 1990, Garcia-Alonso and Garcia-Bellido, 1988)

extramacrochaete^Pel

(Renaud and Simpson, 2002)

Name Synonyms

Secondary FlyBase IDs

References (18)

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