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General Information
Symbol
Dmel\net1
Species
D. melanogaster
Name
FlyBase ID
FBal0012933
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

244bp duplication between nucleotide position 1105 and 1106 (corresponding to a position between amino acids 277 and 278 of the wild type sequence) with the preceding 244bp duplicated.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

net1/Df(2L)Exel6001 results in extra wing veins.

The net1 mutants display ectopic veins and networking of veins in the adult wings.

net1 homozygotes develop extra vein tissue, mainly in the form of ectopic transverse connections between L2 and L3 and between L4 and L5.

Heterozygotes have essentially normal wings, occasionally having a single extra vein near the posterior crossvein (3%).

Homozygotes show ectopic wing veins and plexi.

Homozygotes have extra wing veins.

Appearance of distal extra longitudinal veins preferentially associated with plexi between LII and LIII on one side and between LIV and LV on the other.

Wing veins form plexus-like net; first posterior cell between L3 and L4 widens toward tip; branch missing from posterior crossvein; all veins fused at base of wing, like bi. According to Waddington (1940), spaces form between epithelial layers owing to inadequate contraction during pupal period; spaces later fuse and form extra veins (Diaz-Benjumea, Gonzalez-Gaitan, and Garcia-Bellido, 1989). RK1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

net1 has visible phenotype, enhanceable by CycGHR7/CycGHR7

net1 has visible phenotype, enhanceable by nmoadk2

net1 has visible | recessive phenotype, enhanceable by emc1/emc[+]

Suppressed by
Statement
Reference

net1 has visible | recessive phenotype, suppressible by emcD

Enhancer of
Statement
Reference

net1/net[+] is an enhancer of visible | heat sensitive phenotype of HC2.hs

net1 is an enhancer of visible phenotype of nmoadk2

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

net1 has wing vein | adult stage phenotype, enhanceable by ru1

net1 has wing vein | adult stage phenotype, enhanceable by speck1

net1 has wing vein | ectopic phenotype, enhanceable by Df(1)C246/+

net1 has wing vein | ectopic phenotype, enhanceable by Df(3L)ZN47

net1 has wing vein | ectopic phenotype, enhanceable by HDAC104556/Rpd3[+]

net1 has wing vein | ectopic phenotype, enhanceable by Snr1E1/Snr1[+]

net1 has wing vein | ectopic phenotype, enhanceable by mor[+]/mor1

net1 has wing vein | ectopic phenotype, enhanceable by osa2/osa[+]

net1 has wing vein | ectopic phenotype, enhanceable by Snr1R3/Snr1[+]

net1 has wing vein phenotype, enhanceable by nmoadk2

net1 has wing vein | ectopic phenotype, enhanceable by emc1/emc[+]

NOT Enhanced by
Statement
Reference

net1 has wing vein | ectopic phenotype, non-enhanceable by brm[+]/brm2

net1 has wing vein | ectopic phenotype, non-enhanceable by osa00090/osa[+]

Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference

net1 has wing vein | ectopic phenotype, non-suppressible by brm[+]/brm2

net1 has wing vein | ectopic phenotype, non-suppressible by osa00090/osa[+]

net1 has phenotype, non-suppressible by su(Hw)2

Enhancer of
Statement
Reference

net1/net[+] is an enhancer of wing vein | ectopic phenotype of Snr1E1

net1/net[+] is an enhancer of wing vein | ectopic | heat sensitive phenotype of HC2.hs

net1/net[+] is an enhancer of wing | heat sensitive phenotype of HC2.hs

net1 is an enhancer of wing vein phenotype of nmoadk2

Other
Additional Comments
Genetic Interactions
Statement
Reference

The net1 phenotype (ectopic veins, vein networking) can be enhanced by combination with CycGHR7 but also by combination with mutant alleles of unrelated factors roughoid ru1 or speck sp1 demonstrating high susceptibility of the net1 phenotype to perturbed genetic background.

net1, px72 double mutants develop ectopic wing veins in the L2/L3 and L4/L5 intervein regions. This phenotype is suppressed in flies double heterozygous for osa308 and brm2.

net1 homozygotes develop extra vein tissue, mainly in the form of ectopic transverse connections between L2 and L3 and between L4 and L5. This phenotype is enhanced by ash2I1/+ which also have a reduction in the size of the intervein regions between L2 and L3 (submarginal cell) and between L4 and L5 (discal cell and second posterior cell). The resulting wings have a lanceolate shape.

net ; HC2.hs homozygotes are semi-lethal at 25oC (and viable at 18oC). The animals have massive patches of vein tissue and extensive blistering of the wing.

net1 nmoadk2 double mutant flies show a strong synergistic interaction with respect to the extra wing vein phenotype of each single mutant.

The extra wing vein phenotype of net1 homozygotes is suppressed by emcD and enhanced by emc1/+. net1/+ ; emc1/emc11 flies show an extra wing vein phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Partially rescued by
Comments
Images (1)
Stocks (24)
Notes on Origin
Discoverer

Bridges, 10th March 1931.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (23)