FlyBase Allele Report: Dmel\Snr1[R3]

General Information

Symbol

Dmel\Snr1^R3

Species

D. melanogaster

Name

FlyBase ID

FBal0051957

Feature type

allele

Associated gene

Dmel\Snr1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Dingwall et al., 1995)

Progenitor genotype

Snr1⁰¹³¹⁹

(Dingwall et al., 1995)

Cytology

Description

In-frame translation termination codon at amino acid 131.

(Dingwall et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:5,471,943..5,471,945 [+]

Comment:

Imprecise excision of P element results in an in-frame stop codon at amino acid 131.

(Dingwall et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color | somatic clone

(Zraly et al., 2003)

abnormal size | somatic clone | third instar larval stage

(Xie et al., 2017)

cell lethal | recessive | somatic clone

(Zraly et al., 2003)

female sterile, with Scer\GAL4^Act5C.PI, Snr1^cdel.3.UAS

(Zraly et al., 2003)

female sterile | germline clone

(Zraly et al., 2003)

increased cell death | somatic clone | third instar larval stage

(Xie et al., 2017)

lethal | heat sensitive, with Scer\GAL4^e22c, Snr1^cdel.3.UAS

(Zraly et al., 2003)

lethal | recessive

(Zraly et al., 2002)

lethal - all die before end of larval stage | recessive

(Dingwall et al., 1995)

short lived, with Scer\GAL4^Act5C.PI, Snr1^cdel.3.UAS

(Zraly et al., 2003)

some die during larval stage | recessive

(Dingwall et al., 1995)

suppressor of variegation | dominant, with In(1)w^m4h

(Zraly et al., 2003)

visible (with Snr1^E1)

(Marenda et al., 2004)

visible | recessive | somatic clone

(Zraly et al., 2003)

Phenotype Manifest In

abdominal tergite, with Scer\GAL4^e22c, Snr1^cdel.3.UAS

(Zraly et al., 2003)

adult cuticle | somatic clone

(Zraly et al., 2003)

adult thorax | dorsal & chaeta | somatic clone

(Zraly et al., 2003)

eye | somatic clone

(Zraly et al., 2003)

mechanosensory chaeta & adult abdomen | somatic clone

(Zraly et al., 2003)

mechanosensory chaeta | supernumerary & adult abdomen | somatic clone

(Zraly et al., 2003)

socket & adult abdomen | somatic clone

(Zraly et al., 2003)

wing (with Snr1^E1)

(Marenda et al., 2004)

wing disc | somatic clone | third instar larval stage

(Xie et al., 2017)

wing vein | ectopic (with Snr1^E1)

(Marenda et al., 2004)

Detailed Description

Statement

Reference

Snr1^R3 mutant MARCM somatic clone in the third instar larval wing disc display increased levels of apoptosis and are much smaller compared to control clones.

(Xie et al., 2017)

Snr1^R3/Snr1^E1 flies have an extra vein phenotype in the wings, with extra vein material posterior to wing vein L5 and extending distally from the posterior crossvein.

(Marenda et al., 2004)

The frequency and size of homozygous clones is reduced relative to control clones, indicating that Snr1 is important for cell viability. Homozygous clones in the abdomen result in duplicated, fused or malformed (stunted, twisted or bent) mechanosensory bristles. Within the clones, patches of tissue that lack bristles and/or bristle sockets are seen. Cuticle defects are also seen, including fusion of adjacent segments within clones, loss of pigmentation and cuticle disruptions. Homozygous clones on the dorsal thorax show only minor shortening of bristles within the clone. Homozygous clones in the eye disc result in only slightly reduced eye sizes, with no significant morphological defects. Few homozygous clones are recovered in the head region. Homozygous clones in the leg occur at a similar frequency to control clones and no not result in any obvious mutant phenotype. Females containing homozygous germline clones are infertile and do not produce any eggs. Expression of Snr1^{cdel.3.Scer\UAS} under the control of Scer\GAL4^e22c in a Snr1^R3/+ background results in lethality at 29^oC, and significant cuticle disruption, including incomplete fusion of the abdominal tergites along the dorsal midline. More than 70% of females expressing Snr1^{cdel.3.Scer\UAS} under the control of Scer\GAL4^Act5C.PI in a Snr1^R3 background are sterile. Scer\GAL4^Act5C.PI/Snr1^{cdel.3.Scer\UAS};Snr1^R3 adults show a rapid decrease in viability following eclosion, with the effect being more pronounced among males.

(Zraly et al., 2003)

Heterozygotes are phenotypically normal.

(Dingwall et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

HDAC1⁰⁴⁵⁵⁶, Snr1^R3/Snr1[+] has visible | dominant phenotype, suppressible | partially by brm²

(Zraly et al., 2004)

Enhancer of

Statement

Reference

Snr1^R3/Snr1[+] is an enhancer of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Suppressor of

Statement

Reference

Snr1^R3 is a suppressor of visible | dominant phenotype of Antp^Ns

(Zraly et al., 2003)

Other

Statement

Reference

HDAC1⁰⁴⁵⁵⁶, Snr1^R3/Snr1[+] has visible | dominant phenotype

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+], Snr1^R3 has visible phenotype

(Zraly et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

Snr1^R3 has adult abdomen | somatic clone phenotype, enhanceable by brm[+]/brm²

(Zraly et al., 2003)

NOT Enhanced by

Statement

Reference

Snr1^R3/Snr1^E1 has wing vein | ectopic phenotype, non-enhanceable by ash1⁴

(Marenda et al., 2004)

Snr1^R3/Snr1^E1 has wing phenotype, non-enhanceable by ash1⁴

(Marenda et al., 2004)

Snr1^R3/Snr1^E1 has wing vein | ectopic phenotype, non-enhanceable by trx^E2

(Marenda et al., 2004)

Suppressed by

Statement

Reference

Snr1^R3/Snr1^E1 has wing vein | ectopic phenotype, suppressible by dpp^d-ho/dpp^d-ho

(Marenda et al., 2004)

Snr1^R3/Snr1^E1 has wing vein | ectopic phenotype, suppressible by dpp^s1/dpp^s1

(Marenda et al., 2004)

Snr1^R3/Snr1^E1 has wing vein | ectopic phenotype, suppressible by rho^ve-1/rho^ve-1

(Marenda et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^R3/Snr1[+] has wing phenotype, suppressible | partially by brm²

(Zraly et al., 2004)

HDAC3^B, Snr1^R3/Snr1[+] has wing vein | ectopic phenotype, suppressible | partially by brm²

(Zraly et al., 2004)

HDAC3^B, Snr1^R3/Snr1[+] has wing phenotype, suppressible | partially by brm²

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^R3/Snr1[+] has wing vein | ectopic phenotype, suppressible | partially by brm²

(Zraly et al., 2004)

NOT suppressed by

Statement

Reference

Snr1^R3/Snr1^E1 has wing vein | ectopic phenotype, non-suppressible by ash1⁴

(Marenda et al., 2004)

Snr1^R3/Snr1^E1 has wing phenotype, non-suppressible by ash1⁴

(Marenda et al., 2004)

Snr1^R3/Snr1^E1 has wing vein | ectopic phenotype, non-suppressible by trx^E2

(Marenda et al., 2004)

Enhancer of

Statement

Reference

Snr1^R3/Snr1[+] is an enhancer of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Snr1^R3/Snr1[+] is an enhancer of ommatidium phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Snr1^R3/Snr1^E1 is an enhancer of wing vein phenotype of dpp^s1

(Marenda et al., 2004)

Snr1^R3/Snr1^E1 is an enhancer of wing vein phenotype of Delta^9P

(Marenda et al., 2004)

Snr1^R3/Snr1[+] is an enhancer of wing vein | ectopic phenotype of net¹

(Marenda et al., 2004)

Snr1^R3/Snr1[+] is an enhancer of wing vein | ectopic phenotype of HDAC3^B

(Zraly et al., 2004)

Snr1^R3/Snr1[+] is an enhancer of wing phenotype of HDAC3^B

(Zraly et al., 2004)

Snr1^R3 is an enhancer of phenotype of trx^E2

(Dingwall et al., 1995)

Suppressor of

Statement

Reference

Snr1^R3/Snr1[+] is a suppressor of wing vein phenotype of Scer\GAL4^69B, brm^{K804R.UAS.Tag:HA}

(Marenda et al., 2004)

Snr1^R3/Snr1^E1 is a suppressor of wing vein L5 phenotype of rho^ve-1

(Marenda et al., 2004)

Snr1^R3 is a suppressor of antenna phenotype of Antp^Ns

(Zraly et al., 2003)

Snr1^R3 is a suppressor of leg | ectopic phenotype of Antp^Ns

(Zraly et al., 2003)

Snr1^R3 is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

Snr1^R3, Snr1^cdel.3.UAS, Scer\GAL4^69B is a suppressor of wing vein L5 phenotype of CycE^JP

(Brumby et al., 2002)

Snr1^R3, Scer\GAL4^Act5C.PI, Snr1^cdel.3.UAS is a suppressor of wing vein L5 phenotype of CycE^JP

(Brumby et al., 2002)

Snr1^R3, Snr1^cdel.3.UAS, Scer\GAL4^69B is a suppressor of wing phenotype of CycE^JP

(Brumby et al., 2002)

Snr1^R3, Scer\GAL4^Act5C.PI, Snr1^cdel.3.UAS is a suppressor of wing phenotype of CycE^JP

(Brumby et al., 2002)

Other

Statement

Reference

HDAC1⁰⁴⁵⁵⁶, Snr1^R3/Snr1[+] has wing phenotype

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^R3/Snr1[+] has wing vein | ectopic phenotype

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^R3 has wing phenotype

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^R3 has wing vein | ectopic phenotype

(Zraly et al., 2004)

Snr1^R3/Snr1[+], brm² has postpronotum phenotype

(Dingwall et al., 1995)

Snr1^R3/Snr1[+], brm² has adult prothoracic segment phenotype

(Dingwall et al., 1995)

Snr1^R3, brm² has postpronotum phenotype

(Dingwall et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

The loss of wing veins seen in animals expressing brm^{K804R.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^69B is suppressed by Snr1^R3. The Dl^9P thick vein phenotype is enhanced by Snr1^E1/Snr1^R3. dpp^s1/dpp^s1 Snr1^E1/Snr1^R3 animals show suppression of the Snr1 extra wing vein phenotype and enhancement of the dpp loss of vein phenotype in L5. Snr1^E1/Snr1^R3 suppresses the loss of wing vein L5 seen in rho^ve-1 homozygotes and rho^ve-1 suppresses the Snr1^E1/Snr1^R3 extra wing vein phenotype.

(Marenda et al., 2004)

Rpd3⁰⁴⁵⁵⁶/Snr1^R3 double heterozygotes have wing vein defects; 32% have normal wings, 38% have an ectopic vein emanating from the posterior crossvein and 30% have ectopic veins emanating from the posterior crossvein and posterior to the L5 longitudinal vein. The ectopic wing vein phenotype seen in Rpd3⁰⁴⁵⁵⁶/Snr1^R3 double heterozygotes at 29^oC is partially suppressed by brm²/+.

(Zraly et al., 2004)

Homozygous Snr1^R3 clones induced in a brm²/+ background are less frequently observed and are smaller in size compared to both brm⁺ and control clones induced at similar stages, suggesting an additive effect between brm and Snr1. The presence of brm²/+ enhances the Snr1^R3 clone phenotype in the abdomen. The Antp^Ns/+ antenna to leg transformation is suppressed about 50% by Snr1^R3.

(Zraly et al., 2003)

Loss of one copy of Snr1 does not suppress adult Pc^- mutant phenotypes. Snr1^R3/brm² transheterozygous adults display prothoracic defects, including loss of the humerus.

(Dingwall et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Snr1^E2

(Zraly et al., 2003)

Snr1^E3

(Zraly et al., 2003)

Snr1^E4

(Zraly et al., 2003)

Snr1^E1

(Zraly et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Snr1^R3

(Keegan et al., 2023, Zeng et al., 2013, Curtis et al., 2011)

snr1^R3

(Xie et al., 2017, Melicharek et al., 2008, Marenda et al., 2004, Zraly et al., 2002)

snr1^r3

(Armstrong et al., 2005, Papoulas et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (13)

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