FlyBase Allele Report: Dmel\dpp[s1]

General Information

Symbol

Dmel\dpp^s1

Species

D. melanogaster

Name

FlyBase ID

FBal0003071

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Also Known As

dpp^shv

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Cytology

Polytene chromosomes normal.

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

long lived

(Fife et al., 2024)

visible

(Chauhan et al., 2013, Verheyen et al., 2001, Yu et al., 1996)

visible (with dpp^d-ho)

(Chauhan et al., 2013)

visible | recessive

(Waltzer and Bienz, 1999, Saget et al., 1998, Segal and Gelbart, 1985)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous dpp^s1 mutant flies display a shortened L4 vein and a less penetrant posterior crossvein phenotype.

Flies homozygous for both dpp^s1 and dpp^d-ho display shortened L4, and occasionally, L2 and posterior crossveins.

(Chauhan et al., 2013)

Mutant flies have a mild wing vein loss phenotype.

(Verheyen et al., 2001)

Wing vein 4 fails to reach the wing margin.

(Waltzer and Bienz, 1999)

10 to 35% of homozygous males show loss of claws, and 35 to 70% of homozygous males have short veins.

(Saget et al., 1998)

Distal portion of wing vein L4 is missing.

(Yu et al., 1996)

dpp^s1 dpp^d-ho double mutant chromosome partially suppresses the penetrance of the hh^Mrt phenotype.

(Felsenfeld and Kennison, 1995)

Coordinate mutant.

(Sturtevant and Bier, 1995)

Terminal gap in LII and LIV, a short subterminal extra vein anterior to LIII of the dorsal component and rarely an extra vein parallel to LII.

(Diaz-Benjumea and Garcia-Bellido, 1990)

Affect adult wing venation.

(St. Johnston et al., 1990)

Terminal gaps at the distal ends of longitudinal wing veins L2 and L4. Wings also have very small pieces of extra venation between the longitudinal veins in the distal part of the wing blade and occasional indentation in the nota.

(Segal and Gelbart, 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dpp^d-ho/dpp^s1 has visible phenotype, enhanceable by Lpt¹/Lpt[+]

(Chauhan et al., 2013)

dpp^s1 has visible phenotype, enhanceable by Lpt¹/Lpt[+]

(Chauhan et al., 2013)

dpp^s1 has visible | recessive phenotype, enhanceable by mxc^G43

(Saget et al., 1998)

Enhancer of

Statement

Reference

dpp^s1/dpp[+] is an enhancer of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

dpp^s1/dpp[+] is an enhancer of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

dpp^s1 is an enhancer of visible phenotype of nmo^adk2

(Verheyen et al., 2001)

NOT Enhancer of

Statement

Reference

dpp^s1/dpp^s1 is a non-enhancer of visible | recessive phenotype of mxc^G43

(Saget et al., 1998)

Suppressor of

Statement

Reference

dpp^s1 is a suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

Lpt¹/Lpt[+], dpp^s1 has visible phenotype

(Chauhan et al., 2013)

Lpt¹/Lpt[+], dpp^d-ho/dpp^s1 has visible phenotype

(Chauhan et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

dpp^d-ho/dpp^s1 has posterior crossvein phenotype, enhanceable by Lpt¹/Lpt[+]

(Chauhan et al., 2013)

dpp^s1 has wing vein L4 phenotype, enhanceable by Lpt¹/Lpt[+]

(Chauhan et al., 2013)

dpp^s1 has posterior crossvein phenotype, enhanceable by Lpt¹/Lpt[+]

(Chauhan et al., 2013)

dpp^s1 has wing vein phenotype, enhanceable by Snr1^R3/Snr1^E1

(Marenda et al., 2004)

dpp^s1 has wing vein L4 phenotype, enhanceable by nej³

(Waltzer and Bienz, 1999)

dpp^s1 has wing vein L2 phenotype, enhanceable by nej³

(Waltzer and Bienz, 1999)

dpp^s1 has unguis phenotype, enhanceable by mxc^G43

(Saget et al., 1998)

dpp^s1 has wing vein phenotype, enhanceable by mxc^G43

(Saget et al., 1998)

dpp^s1 has eye phenotype, enhanceable by mxc^G43

(Saget et al., 1998)

Suppressed by

Statement

Reference

dpp^s1 has wing vein L2 phenotype, suppressible by shn^hs.PT-V

(Torres-Vazquez et al., 2000)

dpp^s1 has wing vein L4 phenotype, suppressible by shn^hs.PT-V

(Torres-Vazquez et al., 2000)

dpp^s1 has wing vein phenotype, suppressible by shn^hs.PT-V

(Torres-Vazquez et al., 2000)

dpp^s1 has wing phenotype, suppressible by shn^hs.PT-V

(Torres-Vazquez et al., 2000)

NOT suppressed by

Statement

Reference

dpp^s1 has wing vein phenotype, non-suppressible by tkv⁴

(Penton et al., 1994)

dpp^s1 has wing vein phenotype, non-suppressible by tkv⁵

(Penton et al., 1994)

dpp^s1 has wing vein phenotype, non-suppressible by tkv⁴²⁷

(Penton et al., 1994)

dpp^s1 has wing vein phenotype, non-suppressible by Df(2L)tkv2

(Penton et al., 1994)

Enhancer of

Statement

Reference

dpp^s1/dpp[+] is an enhancer of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

dpp^s1/dpp[+] is an enhancer of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

dpp^s1 is an enhancer of wing vein | ectopic phenotype of nmo^adk2

(Verheyen et al., 2001)

dpp^s1 is an enhancer of posterior crossvein phenotype of Dys^det-1

(Yu et al., 1996)

NOT Enhancer of

Statement

Reference

dpp^s1/dpp^s1 is a non-enhancer of leg phenotype of mxc^G43

(Saget et al., 1998)

Suppressor of

Statement

Reference

dpp^s1/dpp^s1 is a suppressor of wing vein | ectopic phenotype of Snr1^R3/Snr1^E1

(Marenda et al., 2004)

dpp^s1 is a suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

dpp^s1 is a suppressor of wing vein | ectopic phenotype of rho^Stg

(Yu et al., 1996)

Other

Statement

Reference

Lpt¹/Lpt[+], dpp^s1 has wing vein L2 phenotype

(Chauhan et al., 2013)

Lpt¹/Lpt[+], dpp^d-ho/dpp^s1 has wing vein L2 phenotype

(Chauhan et al., 2013)

Lpt¹/Lpt[+], dpp^d-ho/dpp^s1 has posterior crossvein phenotype

(Chauhan et al., 2013)

Dys^det-1, dpp^s1 has wing vein L4 phenotype

(Yu et al., 1996)

dpp^s1, sog^EP2 has wing vein L2 phenotype

(Yu et al., 1996)

dpp^s1, sog^EP3 has wing vein L4 phenotype

(Yu et al., 1996)

dpp^s1, sog^EP7 has wing vein L2 phenotype

(Yu et al., 1996)

dpp^s1, sog^EP7 has wing vein L5 phenotype

(Yu et al., 1996)

dpp^s1, sog^EP7 has wing vein L3 phenotype

(Yu et al., 1996)

dpp^s1, sog^EP7 has wing vein L4 phenotype

(Yu et al., 1996)

dpp^s1, sog^EP2 has wing vein L5 phenotype

(Yu et al., 1996)

dpp^s1, sog^EP2 has wing vein L3 phenotype

(Yu et al., 1996)

dpp^s1, sog^EP2 has posterior crossvein phenotype

(Yu et al., 1996)

dpp^s1, sog^EP2 has wing vein L4 phenotype

(Yu et al., 1996)

dpp^s1, sog^EP3 has wing vein L2 phenotype

(Yu et al., 1996)

dpp^s1, sog^EP3 has wing vein L5 phenotype

(Yu et al., 1996)

dpp^s1, sog^EP3 has wing vein L3 phenotype

(Yu et al., 1996)

dpp^s1, sog^EP3 has posterior crossvein phenotype

(Yu et al., 1996)

dpp^s1, vvl^sep has wing vein L2 phenotype

(de Celis et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Approximately 4% of trans-heterozygous dpp^s1/Lpt¹ flies show a shortened posterior crossvein.

When dpp^s1 is homozygous, Lpt¹/+ flies display shortened L4, and occasionally, L2 wing veins, in addition to the enhancement of the posterior crossvein phenotype.

Approximately 6% of flies trans-heterozygous for Lpt¹/dpp^s1 dpp^d-ho display a shortened posterior crossvein.

Lpt¹/+ flies homozygous for both dpp^s1 and dpp^d-ho show enhancement of the posterior crossvein phenotype relative to trans-heterozygotes, and shortened L2 and L4 veins.

(Chauhan et al., 2013)

dpp^s1/dpp^s1 Snr1^E1/Snr1^R3 animals show suppression of the Snr1 extra wing vein phenotype and enhancement of the dpp loss of vein phenotype in L5.

(Marenda et al., 2004)

dpp^s1 nmo^adk2 flies show an enhancement of the nmo^adk2 ectopic wing vein phenotype, especially in the anterior of the wing blade near vein L2.

(Verheyen et al., 2001)

The dpp^s1 mutant phenotype is enhanced if the flies are also hemizygous for mxc^G43; double mutant flies show increased venation defects and reduced eyes. Does not enhance the leg phenotypes of mxc^G43 hemizygotes.

(Saget et al., 1998)

dpp^s1/dpp^s1; sog^EP2/sog⁺ wings and dpp^s1/dpp^s1; sog^EP3/sog⁺ wings exhibit significantly truncated veins and posterior crossvein. dpp^s1/dpp^s1; sog^EP7/sog⁺ wings exhibit significantly truncated veins. Introduction of dpp^s1 to det¹ homozygotes causes severe truncation of the posterior crossvein and wing vein L4.

(Yu et al., 1996)

tkv⁴, tkv⁵, tkv⁷, tkv⁴²⁷ and Df(2L)tkv2 fail to complement dpp short vein alleles for the wing vein defect.

(Penton et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dpp^s1 is rescued by dpp^7191.lacZ

(Penton et al., 1994)

Comments

The wing vein phenotype is rescued by the transgene carrying dpp^{7191.T:Ecol\lacZ}.

(Penton et al., 1994)

Allele class: shv-w

Images (0)

Mutant

Wild-type

Stocks (11)

Bloomington

397

dpp^s1

398

dpp^s1 dpp^d-ho

6481

dpp^s1 l(2)B73¹ Adc^b-1 cn¹ bw¹/SM1

6475

dpp^s1 l(2)K152¹ Adc^b-1 cn¹ bw¹/SM1

6476

dpp^s1 l(2)I46^I46 Adc^b-1 cn¹ bw¹/SM1

6477

dpp^s1 l(2)30Ba^K2 Adc^b-1 cn¹ bw¹/SM1

6474

dpp^s1 l(2)DA2^M373 Adc^b-1 cn¹ bw¹/SM1

355

net¹ al¹ ex¹ ds¹ S¹ ast¹ dpp^s1 dpp^d-ho rub¹/SM1

1064

T(2;3)ap^Xa, al¹ dpp^s1 cl¹ fy² NimA^j-676 ap^Xa/al¹ dpp^s1 cl¹ fy² NimA^j-676; rec¹ Ubx^bx-34e

Kyoto

105890

dpp^s1

105869

net¹ al¹ ex¹ ds¹ S¹ ast¹ dpp^s1 dpp^d-ho rub¹/SM1

Notes on Origin

Discoverer

Pope, 1947.

Comments

The allele that had been called "shv¹" is renamed dpp^s1.

(Gelbart, 1994.7.29)

Likely to be an enhancer mutation.

(Yu et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

dpp^S1

(Waltzer and Bienz, 1999)

dpp^s1

(Fife et al., 2024, Kim et al., 2017, Chauhan et al., 2013, Curtis et al., 2013)

dpp^shv-1

(Diaz-Benjumea and Garcia-Bellido, 1990)

dpp^shv1

(de Celis et al., 1995)

dpp^shv

(Negreiros et al., 2018, Haley et al., 2008, Araujo et al., 2003, Verheyen et al., 2001, Saget et al., 1998, Yu et al., 1996, Sturtevant and Bier, 1995)

shv

shv¹

(Gelbart, 1994.7.29, Segal and Gelbart, 1985)

Name Synonyms

Secondary FlyBase IDs

FBal0034432

References (24)

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