Open Close
General Information
Symbol
Dmel\tkv427
Species
D. melanogaster
Name
FlyBase ID
FBal0035791
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    tkv427/+ adults do not have any obvious wing phenotypes.

    The anterior and posterior crossveins are absent and the distal end of vein L4 is lost in tkv427/tkv7 wings.

    tkv7/tkv427 flies have ectopic vein fragments around the distal part of vein L2.

    A fraction of tkv7/tkv427 flies show a small notching of the wing tip. The number of dying cells in the late third larval instar tkv7/tkv427 wing disc is increased compared to wild type; a cluster of dying cells appears in the primordial wing tip.

    Homozygotes are phenotypically wild-type. tkv427/Df(2L)tkv2 flies show slight thickening of the wing veins.

    Wing veins are thickened with delta-shaped broadenings at the ends of the veins.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference

    tkv7/tkv427 has visible phenotype, enhanceable by pucE69

    tkv7/tkv427 has visible phenotype, enhanceable by hepCA

    tkv427 has visible | recessive phenotype, enhanceable by gbb1

    Suppressor of
    Statement
    Reference

    tkv[+]/tkv427 is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4A9, anchorGD3613

    Phenotype Manifest In
    Enhanced by
    Statement
    Reference

    tkv7/tkv427 has wing phenotype, enhanceable by pucE69

    tkv7/tkv427 has wing disc phenotype, enhanceable by pucE69

    tkv7/tkv427 has wing phenotype, enhanceable by hepCA

    tkv427 has wing vein phenotype, enhanceable by gbb1

    tkv427 has wing vein phenotype, enhanceable by dpp7191.lacZ

    Suppressed by
    Statement
    Reference

    pucE69/puc[+], tkv7/tkv427 has wing disc phenotype, suppressible by hepr75

    pucE69, tkv7/tkv427 has wing disc phenotype, suppressible by hepr75

    Suppressor of
    Statement
    Reference

    tkv[+]/tkv427 is a suppressor | partially of wing vein phenotype of Scer\GAL4A9, anchorGD3613

    tkv[+]/tkv427 is a suppressor | partially of wing phenotype of Scer\GAL4A9, anchorGD3613

    NOT Suppressor of
    Statement
    Reference

    tkv427 is a non-suppressor of wing vein phenotype of dpps1

    tkv427 is a non-suppressor of wing vein phenotype of dpps5

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Addition of tkv427/+ to animals expressing anchorGD3613 under the control of Scer\GAL4A9 partially suppresses the thickened wing vein phenotype, but does not suppress the increased wing size phenotype.

    The tkv7/tkv427 wing phenotype is significantly enhanced by a single copy of pucE69 or hepCA, and in the case of hepCA a wide region of the wing blade is lost, leaving only the base of the wing. The appearance of the apoptotic cluster in the wing discs of tkv7/tkv427 larvae is more apparent if the larvae are also heterozygous for pucE69. The appearance of the cluster of apoptotic cells is suppressed in hepr75/Y ; tkv7/tkv427 ; pucE69/+ larvae.

    The tkv427/Df(2L)tkv2 wing vein thickening phenotype is enhanced by gbb1.

    The wing vein phenotype is enhanced by the transgene carrying dpp7191.T:Ecol\lacZ. tkv4, tkv5, tkv7, tkv427 and Df(2L)tkv2 fail to complement dpp short vein alleles for the wing vein defect.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (7)