FlyBase Allele Report: Dmel\tkv[427]

General Information

Symbol

Dmel\tkv⁴²⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0035791

Feature type

allele

Associated gene

Dmel\tkv

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Khalsa et al., 1998)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible (with tkv⁷)

(Adachi-Yamada et al., 1999)

visible | recessive

(Adachi-Yamada et al., 1999, Khalsa et al., 1998, Penton et al., 1994)

Phenotype Manifest In

anterior crossvein (with tkv⁷)

(Liu et al., 2011)

posterior crossvein (with tkv⁷)

(Liu et al., 2011)

wing

(Adachi-Yamada et al., 1999)

wing (with tkv⁷)

(Adachi-Yamada et al., 1999)

wing disc (with tkv⁷)

(Adachi-Yamada et al., 1999)

wing vein

(Khalsa et al., 1998, Penton et al., 1994)

wing vein | ectopic

(Adachi-Yamada et al., 1999)

wing vein L4 (with tkv⁷)

(Liu et al., 2011)

Detailed Description

Statement

Reference

tkv⁴²⁷/+ adults do not have any obvious wing phenotypes.

(Wang et al., 2018)

The anterior and posterior crossveins are absent and the distal end of vein L4 is lost in tkv⁴²⁷/tkv⁷ wings.

(Liu et al., 2011)

tkv⁷/tkv⁴²⁷ flies have ectopic vein fragments around the distal part of vein L2.

(Adachi-Yamada et al., 1999)

A fraction of tkv⁷/tkv⁴²⁷ flies show a small notching of the wing tip. The number of dying cells in the late third larval instar tkv⁷/tkv⁴²⁷ wing disc is increased compared to wild type; a cluster of dying cells appears in the primordial wing tip.

(Adachi-Yamada et al., 1999)

Homozygotes are phenotypically wild-type. tkv⁴²⁷/Df(2L)tkv2 flies show slight thickening of the wing veins.

(Khalsa et al., 1998)

Wing veins are thickened with delta-shaped broadenings at the ends of the veins.

(Penton et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

tkv⁷/tkv⁴²⁷ has visible phenotype, enhanceable by puc^E69

(Adachi-Yamada et al., 1999)

tkv⁷/tkv⁴²⁷ has visible phenotype, enhanceable by hep^CA

(Adachi-Yamada et al., 1999)

tkv⁴²⁷ has visible | recessive phenotype, enhanceable by gbb¹

(Khalsa et al., 1998)

Suppressor of

Statement

Reference

tkv[+]/tkv⁴²⁷ is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^A9, anchor^GD3613

(Wang et al., 2018)

tkv[+]/tkv⁴²⁷ is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^A9, anchor^GD3613

(Wang et al., 2018)

Phenotype Manifest In

Enhanced by

Statement

Reference

tkv⁷/tkv⁴²⁷ has wing phenotype, enhanceable by puc^E69

(Adachi-Yamada et al., 1999)

tkv⁷/tkv⁴²⁷ has wing disc phenotype, enhanceable by puc^E69

(Adachi-Yamada et al., 1999)

tkv⁷/tkv⁴²⁷ has wing phenotype, enhanceable by hep^CA

(Adachi-Yamada et al., 1999)

tkv⁴²⁷ has wing vein phenotype, enhanceable by gbb¹

(Khalsa et al., 1998)

tkv⁴²⁷ has wing vein phenotype, enhanceable by dpp^7191.lacZ

(Penton et al., 1994)

Suppressed by

Statement

Reference

puc^E69/puc[+], tkv⁷/tkv⁴²⁷ has wing disc phenotype, suppressible by hep^r75

(Adachi-Yamada et al., 1999)

puc^E69, tkv⁷/tkv⁴²⁷ has wing disc phenotype, suppressible by hep^r75

(Adachi-Yamada et al., 1999)

Suppressor of

Statement

Reference

tkv[+]/tkv⁴²⁷ is a suppressor | partially of wing vein phenotype of Scer\GAL4^A9, anchor^GD3613

(Wang et al., 2018)

tkv[+]/tkv⁴²⁷ is a suppressor | partially of wing phenotype of Scer\GAL4^A9, anchor^GD3613

(Wang et al., 2018)

NOT Suppressor of

Statement

Reference

tkv⁴²⁷ is a non-suppressor of wing vein phenotype of dpp^s1

(Penton et al., 1994)

tkv⁴²⁷ is a non-suppressor of wing vein phenotype of dpp^s5

(Penton et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Addition of tkv⁴²⁷/+ to animals expressing anchor^GD3613 under the control of Scer\GAL4^A9 partially suppresses the thickened wing vein phenotype, but does not suppress the increased wing size phenotype.

(Wang et al., 2018)

The tkv⁷/tkv⁴²⁷ wing phenotype is significantly enhanced by a single copy of puc^E69 or hep^CA, and in the case of hep^CA a wide region of the wing blade is lost, leaving only the base of the wing. The appearance of the apoptotic cluster in the wing discs of tkv⁷/tkv⁴²⁷ larvae is more apparent if the larvae are also heterozygous for puc^E69. The appearance of the cluster of apoptotic cells is suppressed in hep^r75/Y ; tkv⁷/tkv⁴²⁷ ; puc^E69/+ larvae.

(Adachi-Yamada et al., 1999)

The tkv⁴²⁷/Df(2L)tkv2 wing vein thickening phenotype is enhanced by gbb¹.

(Khalsa et al., 1998)

The wing vein phenotype is enhanced by the transgene carrying dpp^{7191.T:Ecol\lacZ}. tkv⁴, tkv⁵, tkv⁷, tkv⁴²⁷ and Df(2L)tkv2 fail to complement dpp short vein alleles for the wing vein defect.

(Penton et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

tkv⁴²⁷

(Wang et al., 2018, Liu et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (7)

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