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General Information
Symbol
Dmel\hepCA
Species
D. melanogaster
Name
FlyBase ID
FBal0098235
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Expression is presumed to be due to a genomic enhancer driving expression of the P{UAS-hep.CA} transgene.

Insertion components
P{UAS-hep.CA}CA
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygotes have wing notches of variable extent.

Shifting hepCA; Scer\GAL4en-e16E; Scer\GAL80ts.αTub84B flies to the none permissive temperature for Scer\GAL80ts.αTub84B induces expression of cell death markers in the posterior compartment of the wing disc by 22 hours after the shift.

10% of heterozygous flies lack part of the wing.

hepCA heterozygotes show notching of the wing in less than 10% of cases. Massive cell death is seen in both the proximal and distal wing primordia in the hepCA late third larval instar wing disc.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

hepCA has visible | dominant phenotype, enhanceable by HDAC104556/Rpd3[+]

Suppressed by
Statement
Reference

hepCA has increased cell death phenotype, suppressible by chm14/chm[+]

hepCA has visible | dominant phenotype, suppressible by chm14/chm[+]

hepCA has visible | dominant phenotype, suppressible by kay1/kay[+]

hepCA has visible | dominant phenotype, suppressible by JraIA109/Jra[+]

hepCA has visible | dominant phenotype, suppressible by Cka2/Cka[+]

Enhancer of
Statement
Reference

hep[+]/hepCA is an enhancer of visible phenotype of dpphr56/dppd8

hepCA is an enhancer of visible phenotype of tkv7/tkv427

hep[+]/hepCA is an enhancer of visible | recessive phenotype of biomb-1

Phenotype Manifest In
Enhanced by
Statement
Reference

hepCA has wing phenotype, enhanceable by HDAC104556/Rpd3[+]

Suppressed by
Statement
Reference

hepCA has wing phenotype, suppressible by chm14/chm[+]

hepCA has wing phenotype, suppressible by kay1/kay[+]

hepCA has wing phenotype, suppressible by JraIA109/Jra[+]

hepCA has wing phenotype, suppressible by Cka2/Cka[+]

Enhancer of
Statement
Reference

hep[+]/hepCA is an enhancer of wing phenotype of dpphr56/dppd8

hepCA is an enhancer of wing phenotype of tkv7/tkv427

hep[+]/hepCA is an enhancer of wing phenotype of biomb-1

Additional Comments
Genetic Interactions
Statement
Reference

The loss of wing tissue seen in some hepCA/+ flies is rescued by Cka2/+.

Dominantly enhances the wing notching phenotype of dppd8/dpphr56, tkv7/tkv427 or biomb-1/Y flies; a wide region of the wing blade is lost, leaving only the base of the wing.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
hep<up>CA(wing trap)</up>
hepCA
Name Synonyms
Secondary FlyBase IDs
    References (5)