FlyBase Allele Report: Dmel\px[1]

General Information

Symbol

Dmel\px¹

Species

D. melanogaster

Name

FlyBase ID

FBal0014102

Feature type

allele

Associated gene

Dmel\px

Associated Insertion(s)

Carried in Construct

Also Known As

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Verheyen et al., 2001, Matakatsu et al., 1999)

visible | recessive

(Wessendorf et al., 1992)

Phenotype Manifest In

eye

(Matakatsu et al., 1999)

leg

(Matakatsu et al., 1999)

wing

(Matakatsu et al., 1999, Wessendorf et al., 1992)

wing vein

(Verheyen et al., 2001)

wing vein | ectopic

(Matakatsu et al., 1999)

Detailed Description

Statement

Reference

Shows no defect outside the wing when homozygous, but shows rough eyes and shortened legs when heterozygous with Df(2R)X58-5.

(Matakatsu et al., 1999)

px¹/bs³ flies have a phenotype similar to px¹/px¹.

(Plough and Ives, 1934)

Wings have network of extra veins, especially towards tips and margins; L4 vein bent near tip. Semidominant with some Minutes. Suppressed by S (Bedichek, 1936); suppresses expression of ve (Thompson, 1973). Venation effect caused by inadequate contraction of wing during pupal stage, leaving spaces between epithelial layers (Waddington, 1940). Vein patterns of px flies studied in lines selected for increased or decreased expression (Thompson, 1974).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

px¹ has visible phenotype, enhanceable by nmo^adk2

(Verheyen et al., 2001)

Suppressed by

Statement

Reference

px¹ has visible | recessive phenotype, suppressible by rho^ve-1/rho[+]

(Wessendorf et al., 1992)

Enhancer of

Statement

Reference

px[+]/px¹ is an enhancer of visible | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

px¹ is an enhancer of visible phenotype of nmo^adk2

(Verheyen et al., 2001)

px[+]/px¹ is an enhancer of visible | dominant phenotype of Delta^4P39

(Wessendorf et al., 1992)

Suppressor of

Statement

Reference

px¹ is a suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

px[+]/px¹ is a suppressor | partially of visible | dominant phenotype of N^Ax-598

(Wessendorf et al., 1992)

px[+]/px¹ is a suppressor of visible phenotype of if³

(Wessendorf et al., 1992)

Phenotype Manifest In

Enhanced by

Statement

Reference

px¹ has wing vein phenotype, enhanceable by nmo^adk2

(Verheyen et al., 2001)

px¹ has phenotype, enhanceable by Egfr^E3/Egfr^E3

(Diaz-Benjumea and Garcia-Bellido, 1990)

px¹ has phenotype, enhanceable by slt¹

(Curry, 1939)

Suppressed by

Statement

Reference

px¹ has wing phenotype, suppressible by rho^ve-1/rho[+]

(Wessendorf et al., 1992)

NOT suppressed by

Statement

Reference

px¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

px[+]/px¹ is an enhancer of wing vein | ectopic | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

px[+]/px¹ is an enhancer of wing | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

px¹ is an enhancer of wing vein phenotype of nmo^adk2

(Verheyen et al., 2001)

px[+]/px¹ is an enhancer of wing phenotype of Delta^4P39

(Wessendorf et al., 1992)

Suppressor of

Statement

Reference

px¹ is a suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

px[+]/px¹ is a suppressor | partially of wing phenotype of N^Ax-598

(Wessendorf et al., 1992)

px[+]/px¹ is a suppressor of wing phenotype of if³

(Wessendorf et al., 1992)

Additional Comments

Genetic Interactions

Statement

Reference

px¹ nmo^adk2 double mutant flies show a synergistic interaction with respect to the extra wing vein phenotype of each single mutant.

(Verheyen et al., 2001)

Dominantly suppresses the wing blister phenotype of if³ flies.

(Wessendorf et al., 1992)

Egfr^E3/Egfr^E3 px¹/px¹ double mutants have a superadditive phenotype.

(Diaz-Benjumea and Garcia-Bellido, 1990)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (63)

Bloomington

377

px¹

378

px¹ bs³

1554

a¹ px¹ or¹

381

px¹ slt¹ speck¹

400

sm¹ px¹ Snap29^pd-1/SM5

713

C(2L)RM-P1, Adc^b-1; C(2R)RM-P4, px¹

716

C(2L)RM-P2, dpy^ov1; C(2R)RM-P4, px¹

715

C(2L)RM-P3, NimA^j-63; C(2R)RM-P4, px¹

3469

Df(2R)PK1, c¹ px¹ speck¹/SM1

Kyoto

105879

px¹

105880

px¹ bs³

107799

T(Y;2)J-D/px¹ bw¹ speck¹

More stocks available...

Notes on Origin

Discoverer

Bridges, 20th Aug. 1914.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

(Curry, 1939, Plough and Ives, 1934)

px¹

(Curtis et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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