FlyBase Allele Report: Dmel\if[3]

General Information

Symbol

Dmel\if³

Species

D. melanogaster

Name

FlyBase ID

FBal0005580

Feature type

allele

Associated gene

Dmel\if

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Bloor and Brown, 1998, Curry, 1939)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

anterior crossvein

(Wilcox et al., 1989)

crossvein

wing

(Han et al., 2012, Ribeiro et al., 2011, Lee et al., 2003, Bloor and Brown, 1998, Walsh and Brown, 1998, Fristrom et al., 1994, Hart et al., 1993, Wessendorf et al., 1992)

wing | cold sensitive

(Brabant and Brower, 1993)

wing blade

(Zhang et al., 2010)

wing vein

Detailed Description

Statement

Reference

Mutants have a blistered wing phenotype.

(Han et al., 2012)

33.7 +/- 2.5% of if³/Y flies have wing blisters.

(Ribeiro et al., 2011)

At 22[o]C, mutant males show no defects in rotation of the genitalia.

(Fraichard et al., 2010)

17% of hemizygous males show wing blistering.

(Zhang et al., 2010)

28% of if³/Y flies have blistered wings.

(Lee et al., 2003)

if³/Y flies have a low frequency of wing blisters (=<10%).

(D'Avino and Thummel, 2000)

Hemizygotes exhibit a large centrally positioned bubble in one or both wings.

(Bloor and Brown, 1998)

48% of hemizygous males have wing blisters at 25^oC, 4% have wing blisters at 28^oC.

(Walsh and Brown, 1998)

Wing blister phenotype is dominantly enhanced by bs mutations. Enhances the blister but not vein phenotype of bs mutations.

(Fristrom et al., 1994)

33 to 66% of homozygotes show wing blistering.

(Hart et al., 1993)

if³/if³ flies show reduced levels of PS2 integrin on the surfaces of some imaginal disc cells (especially in the ventral region), but levels of this integrin in muscle, salivary glands and most other tissues seem to be normal. Penetrance is reduced in if³/if^k27e flies by low temperature and crowding.

(Brower and Jaffe, 1989)

Small blisters on the wing surface, centered on the anterior crossvein. Heterozygotes with if^k27e exhibit a much higher frequency of blistering.

(Wilcox et al., 1989)

Phenotype resembles if¹ and if².

(Curry, 1939)

Resembles if¹. Longitudinal veins thickened, especially at wing base. Anterior crossvein thickened. Adult wings typically show large round wing blisters, but the penetrance of this phenotype in homo- and hemizygotes is variable. if³/if^k27e flies show an increase in penetrance (from 15-20% in homozygotes to 60-70% in the heteroalleles).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

if³ has visible phenotype, enhanceable by Tsp74F[+]/Tsp74F¹, Tsp66E²/Tsp66E²

(Han et al., 2012)

if³ has visible phenotype, enhanceable by mtm^Δ77/mtm[+]

(Ribeiro et al., 2011)

if³ has visible | recessive phenotype, enhanceable by Pgant3^m1/pgant3[+]

(Zhang et al., 2010)

if³ has visible | recessive phenotype, enhanceable by pgant3[+]/Pgant3^m2

(Zhang et al., 2010)

if³ has visible phenotype, enhanceable by by²/by[+]

(Lee et al., 2003)

if³ has visible | recessive phenotype, enhanceable by puri[+]/puri^V15

(Walsh and Brown, 1998)

if³ has visible | recessive phenotype, enhanceable by puri[+]/puri^V4

(Walsh and Brown, 1998)

if³ has visible | recessive phenotype, enhanceable by how[+]/how^T1

(Walsh and Brown, 1998)

if³ has visible | recessive phenotype, enhanceable by how[+]/how^T90

(Walsh and Brown, 1998)

if³ has visible | recessive phenotype, enhanceable by cass^E48/cass[+]

(Walsh and Brown, 1998)

if³ has visible | recessive phenotype, enhanceable by blo[+]/blo^V134

(Walsh and Brown, 1998)

if³ has visible | recessive phenotype, enhanceable by bs^V100/bs[+]

(Walsh and Brown, 1998)

if³ has visible | recessive phenotype, enhanceable by bs[+]/bs^V121

(Walsh and Brown, 1998)

if³ has visible | recessive phenotype, enhanceable by moa[+]/jbug^V50

(Walsh and Brown, 1998)

if³ has visible phenotype, enhanceable by bs[+]/bs²

(Wessendorf et al., 1992)

Suppressed by

Statement

Reference

if³ has visible phenotype, suppressible by Scer\GAL4^da.G32/Tsp66E^UAS.Tag:HA

(Han et al., 2012)

if³ has visible phenotype, suppressible by Hsap\CD82^UAS.Tag:HA/Scer\GAL4^da.G32

(Han et al., 2012)

if³ has visible phenotype, suppressible by sli²/sli[+]

(Wessendorf et al., 1992)

if³ has visible phenotype, suppressible by px[+]/px¹

(Wessendorf et al., 1992)

NOT Enhancer of

Statement

Reference

if[+]/if³ is a non-enhancer of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

if[+]/if³ is a non-enhancer of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

NOT Suppressor of

Statement

Reference

if[+]/if³ is a non-suppressor of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

if[+]/if³ is a non-suppressor of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

if³ has wing phenotype, enhanceable by Tsp74F[+]/Tsp74F¹, Tsp66E²/Tsp66E²

(Han et al., 2012)

if³ has wing phenotype, enhanceable by mtm^Δ77/mtm[+]

(Ribeiro et al., 2011)

if³ has wing blade phenotype, enhanceable by Pgant3^m1/pgant3[+]

(Zhang et al., 2010)

if³ has wing blade phenotype, enhanceable by pgant3[+]/Pgant3^m2

(Zhang et al., 2010)

if³ has wing phenotype, enhanceable by by²/by[+]

(Lee et al., 2003)

if³ has phenotype, enhanceable by crol^3ex5

(D'Avino and Thummel, 2000)

if³ has wing phenotype, enhanceable by EcR^C300Y

(D'Avino and Thummel, 2000)

if³ has wing phenotype, enhanceable by EcR^M554fs

(D'Avino and Thummel, 2000)

if³ has wing phenotype, enhanceable by crol⁰⁴⁴¹⁸

(D'Avino and Thummel, 2000)

if³ has wing phenotype, enhanceable by crol⁰⁶⁴⁷⁰

(D'Avino and Thummel, 2000)

if³ has wing phenotype, enhanceable by crol^k08217

(D'Avino and Thummel, 2000)

if³ has phenotype, enhanceable by e(if)1¹

(Bloor and Brown, 1998)

if³ has wing phenotype, enhanceable by puri[+]/puri^V15

(Walsh and Brown, 1998)

if³ has wing phenotype, enhanceable by puri[+]/puri^V4

(Walsh and Brown, 1998)

if³ has wing phenotype, enhanceable by how[+]/how^T1

(Walsh and Brown, 1998)

if³ has wing phenotype, enhanceable by cass^E48/cass[+]

(Walsh and Brown, 1998)

if³ has wing phenotype, enhanceable by how^T90

(Walsh and Brown, 1998)

if³ has wing phenotype, enhanceable by blo[+]/blo^V134

(Walsh and Brown, 1998)

if³ has wing phenotype, enhanceable by bs^V100/bs[+]

(Walsh and Brown, 1998)

if³ has wing phenotype, enhanceable by bs[+]/bs^V121

(Walsh and Brown, 1998)

if³ has wing phenotype, enhanceable by moa[+]/jbug^V50

(Walsh and Brown, 1998)

if³ has wing phenotype, enhanceable by RpL19^P

(Hart et al., 1993)

if³ has wing phenotype, enhanceable by Df(2R)ES1

(Hart et al., 1993)

if³ has wing phenotype, enhanceable by Df(2R)M60E

(Hart et al., 1993)

if³ has wing phenotype, enhanceable by RpL19^ex16

(Hart et al., 1993)

if³ has wing phenotype, enhanceable by RpL19^ex51

(Hart et al., 1993)

if³ has wing phenotype, enhanceable by bs[+]/bs²

(Wessendorf et al., 1992)

if³ has wing phenotype, enhanceable by mys⁸

(Wilcox et al., 1989)

NOT Enhanced by

Statement

Reference

if³ has wing phenotype, non-enhanceable by auk^V106/auk[+]

(Walsh and Brown, 1998)

if³ has wing phenotype, non-enhanceable by auk[+]/auk^V162

(Walsh and Brown, 1998)

if³ has wing phenotype, non-enhanceable by blo^V99/blo[+]

(Walsh and Brown, 1998)

if³ has wing phenotype, non-enhanceable by cass^E44/cass[+]

(Walsh and Brown, 1998)

if³ has wing phenotype, non-enhanceable by shot^V104/shot[+]

(Walsh and Brown, 1998)

if³ has wing phenotype, non-enhanceable by shot[+]/shot^V167

(Walsh and Brown, 1998)

if³ has wing phenotype, non-enhanceable by jbug^V88/moa[+]

(Walsh and Brown, 1998)

if³ has wing phenotype, non-enhanceable by pyg[+]/pyg^E16

(Walsh and Brown, 1998)

if³ has wing phenotype, non-enhanceable by pyg^E50/pyg[+]

(Walsh and Brown, 1998)

if³ has wing phenotype, non-enhanceable by tak[+]/tak^V27

(Walsh and Brown, 1998)

if³ has wing phenotype, non-enhanceable by tak^V42/tak[+]

(Walsh and Brown, 1998)

if³/if^B4 has wing phenotype, non-enhanceable by pot[+]/pot^P3

(Walsh and Brown, 1998)

Suppressed by

Statement

Reference

if³ has wing phenotype, suppressible by Hsap\CD82^UAS.Tag:HA/Scer\GAL4^da.G32

(Han et al., 2012)

if³ has wing phenotype, suppressible by Scer\GAL4^da.G32/Tsp66E^UAS.Tag:HA

(Han et al., 2012)

if³ has wing phenotype, suppressible by sli²/sli[+]

(Wessendorf et al., 1992)

if³ has wing phenotype, suppressible by px[+]/px¹

(Wessendorf et al., 1992)

NOT suppressed by

Statement

Reference

if³ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

if³ is an enhancer of egg | maternal effect phenotype of Tsp66E²

(Han et al., 2012)

if³ is an enhancer of wing phenotype of mys⁸

(Wilcox et al., 1989)

NOT Enhancer of

Statement

Reference

if[+]/if³ is a non-enhancer of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

if[+]/if³ is a non-enhancer of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

NOT Suppressor of

Statement

Reference

if[+]/if³ is a non-suppressor of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

if[+]/if³ is a non-suppressor of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

Other

Statement

Reference

if³, mys^b13 has male genitalia phenotype

(Fraichard et al., 2010)

if³, p130CAS¹ has wing phenotype

(Tikhmyanova et al., 2010)

if³, mys⁸ has wing phenotype

(Brabant and Brower, 1993)

Additional Comments

Genetic Interactions

Statement

Reference

if³ enhances the short-egg phenotype seen in eggs laid by Tsp66E² females.

The penetrance of the if³ wing blister phenotype is enhanced if the flies also carry Tsp66E²/Tsp66E² Tsp74F¹.

Expression of Tsp66E^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^da.G32 dramatically reduces the if³ wing blister phenotype.

(Han et al., 2012)

mtm^Δ77/+ increases the penetrance of the wing blister phenotype seen in if³/Y flies from 33.7 +/- 2.5% to 65.4 +/- 4.7%.

(Ribeiro et al., 2011)

100% of mys^b13 if³ double mutant males have under-rotated genitalia at 22[o]C, with 61% of them being greater than 180[o] under-rotated.

(Fraichard et al., 2010)

Approximately 27% of if³; p130CAS¹ double homozygous mutants and 25% of if³/if³; p130CAS¹/+ mutants emerge as adults with significantly exacerbated wing blistering defects.

(Tikhmyanova et al., 2010)

The penetrance of the wing blistering phenotype seen in if³/Y flies (17%) is increased if they are also heterozygous for either pgant3^m1 (76% penetrance) or for pgant3^m2 (52% penetrance).

(Zhang et al., 2010)

70% of if³/Y ; by²/+ flies have blistered wings. 100% of if³/Y ; by²/by² flies have blistered wings.

(Lee et al., 2003)

The addition of crol⁰⁴⁴¹⁸, crol⁰⁶⁴⁷⁰ or crol^k08217 enhances the wing blistering phenotype of if³/Y flies by 3-4 fold in the case of crol⁰⁴⁴¹⁸ and crol⁰⁶⁴⁷⁰ and about 7 fold in the case of crol^k08217. The addition of crol^3ex5 enhances the wing blistering phenotype of if³/Y flies by about two-fold. This is significantly less than the enhancement seen by crol^k08217. The addition of EcR^C300Y or EcR^M554fs enhances the wing blistering phenotype of if³/Y flies by about five or nine-fold respectively.

(D'Avino and Thummel, 2000)

The frequency of wing blisters in if³ hemizygotes is dominantly enhanced by bs^V100, bs^V121, puri^V4, puri^V15, how^T1, how^T90, cass^E48, blo^V134 or moa^V50. The frequency of wing blisters in if³ hemizygotes is not dominantly enhanced by pyg^E16, pyg^E50, shot^V104, shot^V167, tak^V27, tak^V42, auk^V106, auk^V162, cass^E44, blo^V99 or moa^V88. The frequency of wing blisters seen in if³/if^B4 flies is not dominantly enhanced by pot^P3.

(Walsh and Brown, 1998)

Double mutants with mys⁸ have wing blister phenotype.

(Brabant and Brower, 1993)

The frequency of wing blistering in if³ flies is enhanced by one copy of RpL19^P, Df(2R)ES1 or Df(2R)M60E. The wing blistering phenotype is also enhanced by RpL19^ex16 and RpL19^ex51.

(Hart et al., 1993)

The wing blister phenotype of if³ flies is dominantly enhanced by bs² and dominantly suppressed by sli² and by px¹.

(Wessendorf et al., 1992)

Double hemizygous and homozygous mutants with mys⁸ display an extreme wing phenotype, wings are folded and unexpanded, veins and aberrant crossveins can be seen.

(Wilcox et al., 1989)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\CD82^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^da.G32 dramatically reduces the if³ wing blister phenotype.

(Han et al., 2012)

Complementation and Rescue Data

Complements

if^13ts

(Bloor and Brown, 1998)

if¹⁷

(Bloor and Brown, 1998)

if²¹

(Bloor and Brown, 1998)

if^2B1

(Bloor and Brown, 1998)

if³⁵

(Bloor and Brown, 1998)

if^SEF

(Bloor and Brown, 1998)

if^B4

(Bloor and Brown, 1998)

Fails to complement

if^C2B

(Bloor and Brown, 1998)

if^C4D

(Bloor and Brown, 1998)

if^B4

(Bloor and Brown, 1998)

Rescued by

if³ is rescued by if^+t39

(Brown, 1994)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

3960

if³

Kyoto

107534

if³

Notes on Origin

Discoverer

Curry, Feb. 1938.

Curry, Feb. 1938

(Curry, 1939)

Arose in: w^t ptg¹ stock.

(Curry, 1939)

Comments

Class IV mutation.

(Bloor and Brown, 1998)

Altered expression of PS2α protein.

(Wilcox et al., 1989)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

if³

(Thuveson et al., 2019, Han et al., 2012, Ribeiro et al., 2011, Fraichard et al., 2010, Popodi et al., 2010-, Tikhmyanova et al., 2010, Zhang et al., 2010, Christensen et al., 2009.2.28, Christensen et al., 2008.9.3, Christensen et al., 2008.9.3, Christensen et al., 2008.9.3, Christensen et al., 2008.12.28)

Name Synonyms

Secondary FlyBase IDs

References (28)

Report Sections

Open Close