FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\howT1
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General Information
Symbol
Dmel\howT1
Species
D. melanogaster
Name
FlyBase ID
FBal0093785
Feature type
allele
Associated gene
Dmel\how
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Walsh and Brown, 1998)
Mutagen
X ray
(Walsh and Brown, 1998)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones in the wing produce wing blisters. howT1/howT90 embryos show dramatic defects, including a dorsal open or tail-up phenotype. The germ band fails to retract normally, the embryos remain dorsally open and the head fails to involute.

      (Walsh and Brown, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      how[+]/howT1 is an enhancer of visible | recessive phenotype of if3

      (Walsh and Brown, 1998)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      how[+]/howT1 is an enhancer of wing phenotype of if3

      (Walsh and Brown, 1998)
      NOT Enhancer of
      Statement
      Reference

      how[+]/howT1 is a non-enhancer of wing phenotype of mys8

      (Walsh and Brown, 1998)

      how[+]/howT1 is a non-enhancer of wing phenotype of mewA1-5

      (Walsh and Brown, 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dominantly enhances the frequency of wing blisters in if3 hemizygotes. Does not dominantly enhance the frequency of wing blisters in mewA1-5 or mys8 hemizygotes.

      (Walsh and Brown, 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: Mutation that produces wing blister in homozygous clones.

      (Walsh and Brown, 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      howT1
      sciT1
      (Walsh and Brown, 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)